Glycated hemoglobin as a surrogate for evaluating the effectiveness of drugs in diabetes mellitus trials: a systematic review and trial-level meta-analysis

The objective of this study was to investigate whether glycated hemoglobin (HbA1c) is a valid surrogate for evaluating the effectiveness of antihyperglycemic drugs in diabetes mellitus (DM) trials. We conducted a systematic review of placebo-controlled randomized clinical trials (RCTs) evaluating th...

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Veröffentlicht in:	International journal of technology assessment in health care 2022-01, Vol.38 (1), p.e12-e12, Article e12
Hauptverfasser:	Rivera, Paola Andrea, Rodríguez-Zúñiga, Milton J. M., Caballero-Alvarado, José, Fiestas, Fabián
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Assessment Cerebral infarction Clinical outcomes Clinical trials Confidence intervals Congestive heart failure Correlation coefficient Correlation coefficients Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetic retinopathy Drugs Evaluation Glycated Hemoglobin A - analysis Health services Heart attacks Heart failure Hemoglobin Humans Hypoglycemia Hypoglycemic Agents - therapeutic use Kidneys Laboratories Meta-analysis Mortality Myocardial infarction Patients Pharmaceutical Preparations Placebos Regression analysis Renal failure Statistical analysis Stroke Systematic review Validity
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