Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs
Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox re...
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| Veröffentlicht in: | Analytical methods 2022-03, Vol.14 (11), p.194-112 |
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| creator | Macedo, Lucyano J. A Rodrigues, Fernando P Hassan, Ayaz Máximo, Leandro N. C Zobi, Fabio da Silva, Roberto S Crespilho, Frank N |
| description | Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating
in situ
drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing an important role since the last decade because of its great potential to achieve more robust and controlled pharmacological effects against several diseases, including cancer. An important aspect in the development of these drugs is to understand their cellular properties, such as uptake, accumulation, activity, and toxicity. In this review, we present the potential application of micro-FTIR and its importance for studying metal-based drugs, highlighting the perspectives of chemistry of living cells. We also emphasise bioimaging, which is of high importance to localize the cellular processes, for a proper understanding of the mechanism of action.
Micro-FTIR imaging has opened new possibilities for investigating in situ drug release, redox chemistry effects with biological molecules, DNA and drug interactions, membranes dynamic, and redox reaction with proteins at the single cell level. |
| doi_str_mv | 10.1039/d1ay01198g |
| format | Article |
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in situ
drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing an important role since the last decade because of its great potential to achieve more robust and controlled pharmacological effects against several diseases, including cancer. An important aspect in the development of these drugs is to understand their cellular properties, such as uptake, accumulation, activity, and toxicity. In this review, we present the potential application of micro-FTIR and its importance for studying metal-based drugs, highlighting the perspectives of chemistry of living cells. We also emphasise bioimaging, which is of high importance to localize the cellular processes, for a proper understanding of the mechanism of action.
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Micro-FTIR imaging has opened new possibilities for investigating in situ drug release, redox chemistry effects with biological molecules, DNA and drug interactions, membranes dynamic, and redox reaction with proteins at the single cell level.</description><subject>Biological effects</subject><subject>Chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Fourier transforms</subject><subject>Infrared spectroscopy</subject><subject>Medical imaging</subject><subject>Microscopy</subject><subject>Redox reactions</subject><subject>Robust control</subject><subject>Toxicity</subject><issn>1759-9660</issn><issn>1759-9679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0UFLwzAUB_AgitPpxbsS8CJCNWnapjmO6eZgKMg8eCpp8jo62qYmrbhvb-bmBE8vJD8e7_2D0AUld5Qwca-pXBNKRbo8QCeUxyIQCReH-3NCBujUuRUhiWAJPUYDFgkWcxGdoOzZNIEG19ledeUn4NpUoPpKWjxZzF6xa0F11tSlssYp065xYSy2ICvclTVg6Rw4V0PTYVP4e22-cA2drCqjbb90Z-iokJWD810dorfJ42L8FMxfprPxaB6oMOGdH5JBLlnImdRRqkkqfKFJmIdUEa6IiFnEUw1hwXNOlVTCu4gVlECoPWZDdLPt21rz0ft9srp0CqpKNmB6l4UJ9c1TwmJPr__Rlelt46fzKiKCx5HPaYhut2qzuLNQZK0ta2nXGSXZJvbsgY7ef2Kfeny1a9nnNeg9_c3Zg8stsE7tX__-jX0DGJOHww</recordid><startdate>20220317</startdate><enddate>20220317</enddate><creator>Macedo, Lucyano J. 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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Biological effects Chemistry Deoxyribonucleic acid DNA Drug development Drugs Fourier transforms Infrared spectroscopy Medical imaging Microscopy Redox reactions Robust control Toxicity |
| title | Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs |
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