A unique aromatic cluster near the active site of H. pylori CPA is essential for catalytic function

Polyamines are essential for cell growth and proliferation. In plants and many bacteria, including Helicobacter pylori, the parent polyamine putrescine is only produced through the metabolism of N-carbamoylputrescine by N-carbamoylputrescine amidase (CPA). Thus, CPA is a crucial intermediate enzyme....

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Veröffentlicht in:	Biophysical journal 2022-01, Vol.121 (2), p.248-262
Hauptverfasser:	Sarkar, Ditsa, Vijayan, Ramachandran, Gourinath, Samudrala, Sau, Apurba Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Catalytic Domain Helicobacter pylori Humans Tryptophan - metabolism
Online-Zugang:	Volltext
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