Experimental and Theoretical DFT Study of Cu(I)/N,N‑Disubstituted‑N′‑acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells

Six complexes with the general formula [Cu(acylthioureato)(PPh3)2] were synthesized and characterized using spectroscopic techniques (IR, UV/visible, and 1D and 2D NMR), mass spectrometry, elemental analysis, and X-ray diffraction. Interpretation of the in vitro cytotoxicity data of Cu(I) complex...

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Veröffentlicht in:	Inorganic chemistry 2022-01, Vol.61 (1), p.664-677
Hauptverfasser:	Leite, Celisnolia M, Honorato, João, Martin, Ana Carolina B. M, Silveira, Rafael G, Colombari, Felippe M, Amaral, Jéssica C, Costa, Analu R, Cominetti, Márcia R, Plutín, Ana M, de Aguiar, Debora, Vaz, Boniek G, Batista, Alzir A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Actin Cytoskeleton - metabolism Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Copper - chemistry Copper - pharmacology Density Functional Theory Drug Screening Assays, Antitumor Humans Molecular Structure Thiourea - chemistry Thiourea - pharmacology Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - pathology
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