Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier

Glomerular diseases are a major cause for chronic kidney disorders. In most cases podocyte injury is causative for disease development. Cytoskeletal rearrangements and morphological changes are hallmark features of podocyte injury and result in dedifferentiation and loss of podocytes. Here, we estab...

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Veröffentlicht in:Kidney international 2022-04, Vol.101 (4), p.733-751
Hauptverfasser: Koehler, Sybille, Odenthal, Johanna, Ludwig, Vivian, Unnersjö Jess, David, Höhne, Martin, Jüngst, Christian, Grawe, Ferdi, Helmstädter, Martin, Janku, Johanna L., Bergmann, Carsten, Hoyer, Peter F., Hagmann, H. Henning, Walz, Gerd, Bloch, Wilhelm, Niessen, Carien, Schermer, Bernhard, Wodarz, Andreas, Denholm, Barry, Benzing, Thomas, Iden, Sandra, Brinkkoetter, Paul T.
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Sprache:eng
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