Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate in southern China and Southeast Asia and an evident ethnic and geographical distribution. Circular RNAs (circRNAs) are single‐stranded noncoding RNAs with covalent, closed‐loop stru...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2022-02, Vol.44 (2), p.494-504 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 504 |
|---|---|
| container_issue | 2 |
| container_start_page | 494 |
| container_title | Head & neck |
| container_volume | 44 |
| creator | Li, Wanpeng Xu, Rui Zhu, Bijun Wang, Huan Zhang, Huankang Hu, Li Li, Houyong Sun, Xicai Yu, Hongmeng Wang, Dehui |
| description | Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate in southern China and Southeast Asia and an evident ethnic and geographical distribution. Circular RNAs (circRNAs) are single‐stranded noncoding RNAs with covalent, closed‐loop structures. They are characterized by high stability and abundance, are evolutionarily conserved, and exhibit tissue/developmental stage specificity. Previous studies have shown that circRNAs are associated with the occurrence and development of various malignant tumors. However, the expression patterns and clinical significance of circRNAs in NPC remain ambiguous. Hence, the present review focuses on the biogenesis and regulation of circRNAs, and the functional roles of abnormally expressed circRNAs in NPC. In addition, the current review discusses the possibility of utilizing circRNAs as potential clinical biomarkers for the diagnosis and prognosis of NPC. |
| doi_str_mv | 10.1002/hed.26962 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2612387977</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2620013932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-ffb7d6e5d80cc58a01c369069c07afabc9aad92d1832948e57aaf8d557c323c23</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRbK0e_AMS8KKHtPuRZLPeSmytUBREz8t0s7Fbkk3dbZD-e7e2vQieZhgeHuZ9EbomeEgwpqOlLoc0Exk9QX2CBY8xS_jpbk9YzDBPeujC-xXGmGUJPUc9lghGmBB9VBTGqa4GF729jP1DNO2s2pjW-ghsGTVaLcEa3_jI2MiCb9dLcFv7qaGOFDhlbNvAJTqroPb66jAH6GM6eS9m8fz16bkYz2PFUkbjqlrwMtNpmWOl0hwwUSwTOBMKc6hgoQRAKWhJckZFkuuUA1R5maZcMcoUZQN0t_euXfvVab-RjfFK1zVY3XZe0oxQlnPBeUBv_6CrtnM2fBcoinEIz3bC-z2lXOu905VcO9OEgJJguWtWhmblb7OBvTkYu0UTrkfyWGUARnvg29R6-79JziaPe-UPz-CBDA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2620013932</pqid></control><display><type>article</type><title>Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Li, Wanpeng ; Xu, Rui ; Zhu, Bijun ; Wang, Huan ; Zhang, Huankang ; Hu, Li ; Li, Houyong ; Sun, Xicai ; Yu, Hongmeng ; Wang, Dehui</creator><creatorcontrib>Li, Wanpeng ; Xu, Rui ; Zhu, Bijun ; Wang, Huan ; Zhang, Huankang ; Hu, Li ; Li, Houyong ; Sun, Xicai ; Yu, Hongmeng ; Wang, Dehui</creatorcontrib><description>Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate in southern China and Southeast Asia and an evident ethnic and geographical distribution. Circular RNAs (circRNAs) are single‐stranded noncoding RNAs with covalent, closed‐loop structures. They are characterized by high stability and abundance, are evolutionarily conserved, and exhibit tissue/developmental stage specificity. Previous studies have shown that circRNAs are associated with the occurrence and development of various malignant tumors. However, the expression patterns and clinical significance of circRNAs in NPC remain ambiguous. Hence, the present review focuses on the biogenesis and regulation of circRNAs, and the functional roles of abnormally expressed circRNAs in NPC. In addition, the current review discusses the possibility of utilizing circRNAs as potential clinical biomarkers for the diagnosis and prognosis of NPC.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26962</identifier><identifier>PMID: 34931399</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>biogenesis ; biomarker ; Biomarkers ; circRNAs ; functional mechanism ; Geographical distribution ; Humans ; Mucosa ; Nasopharyngeal carcinoma ; Nasopharyngeal Carcinoma - genetics ; Nasopharyngeal Carcinoma - pathology ; Nasopharyngeal Neoplasms - genetics ; Prognosis ; RNA, Circular - genetics ; Throat cancer ; Tumors</subject><ispartof>Head & neck, 2022-02, Vol.44 (2), p.494-504</ispartof><rights>2021 Wiley Periodicals LLC.</rights><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-ffb7d6e5d80cc58a01c369069c07afabc9aad92d1832948e57aaf8d557c323c23</citedby><cites>FETCH-LOGICAL-c3532-ffb7d6e5d80cc58a01c369069c07afabc9aad92d1832948e57aaf8d557c323c23</cites><orcidid>0000-0003-0346-3193</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26962$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26962$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34931399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Wanpeng</creatorcontrib><creatorcontrib>Xu, Rui</creatorcontrib><creatorcontrib>Zhu, Bijun</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Zhang, Huankang</creatorcontrib><creatorcontrib>Hu, Li</creatorcontrib><creatorcontrib>Li, Houyong</creatorcontrib><creatorcontrib>Sun, Xicai</creatorcontrib><creatorcontrib>Yu, Hongmeng</creatorcontrib><creatorcontrib>Wang, Dehui</creatorcontrib><title>Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate in southern China and Southeast Asia and an evident ethnic and geographical distribution. Circular RNAs (circRNAs) are single‐stranded noncoding RNAs with covalent, closed‐loop structures. They are characterized by high stability and abundance, are evolutionarily conserved, and exhibit tissue/developmental stage specificity. Previous studies have shown that circRNAs are associated with the occurrence and development of various malignant tumors. However, the expression patterns and clinical significance of circRNAs in NPC remain ambiguous. Hence, the present review focuses on the biogenesis and regulation of circRNAs, and the functional roles of abnormally expressed circRNAs in NPC. In addition, the current review discusses the possibility of utilizing circRNAs as potential clinical biomarkers for the diagnosis and prognosis of NPC.</description><subject>biogenesis</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>circRNAs</subject><subject>functional mechanism</subject><subject>Geographical distribution</subject><subject>Humans</subject><subject>Mucosa</subject><subject>Nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Carcinoma - genetics</subject><subject>Nasopharyngeal Carcinoma - pathology</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Prognosis</subject><subject>RNA, Circular - genetics</subject><subject>Throat cancer</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQhhdRbK0e_AMS8KKHtPuRZLPeSmytUBREz8t0s7Fbkk3dbZD-e7e2vQieZhgeHuZ9EbomeEgwpqOlLoc0Exk9QX2CBY8xS_jpbk9YzDBPeujC-xXGmGUJPUc9lghGmBB9VBTGqa4GF729jP1DNO2s2pjW-ghsGTVaLcEa3_jI2MiCb9dLcFv7qaGOFDhlbNvAJTqroPb66jAH6GM6eS9m8fz16bkYz2PFUkbjqlrwMtNpmWOl0hwwUSwTOBMKc6hgoQRAKWhJckZFkuuUA1R5maZcMcoUZQN0t_euXfvVab-RjfFK1zVY3XZe0oxQlnPBeUBv_6CrtnM2fBcoinEIz3bC-z2lXOu905VcO9OEgJJguWtWhmblb7OBvTkYu0UTrkfyWGUARnvg29R6-79JziaPe-UPz-CBDA</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Li, Wanpeng</creator><creator>Xu, Rui</creator><creator>Zhu, Bijun</creator><creator>Wang, Huan</creator><creator>Zhang, Huankang</creator><creator>Hu, Li</creator><creator>Li, Houyong</creator><creator>Sun, Xicai</creator><creator>Yu, Hongmeng</creator><creator>Wang, Dehui</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0346-3193</orcidid></search><sort><creationdate>202202</creationdate><title>Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma</title><author>Li, Wanpeng ; Xu, Rui ; Zhu, Bijun ; Wang, Huan ; Zhang, Huankang ; Hu, Li ; Li, Houyong ; Sun, Xicai ; Yu, Hongmeng ; Wang, Dehui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-ffb7d6e5d80cc58a01c369069c07afabc9aad92d1832948e57aaf8d557c323c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>biogenesis</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>circRNAs</topic><topic>functional mechanism</topic><topic>Geographical distribution</topic><topic>Humans</topic><topic>Mucosa</topic><topic>Nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Carcinoma - genetics</topic><topic>Nasopharyngeal Carcinoma - pathology</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Prognosis</topic><topic>RNA, Circular - genetics</topic><topic>Throat cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Wanpeng</creatorcontrib><creatorcontrib>Xu, Rui</creatorcontrib><creatorcontrib>Zhu, Bijun</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Zhang, Huankang</creatorcontrib><creatorcontrib>Hu, Li</creatorcontrib><creatorcontrib>Li, Houyong</creatorcontrib><creatorcontrib>Sun, Xicai</creatorcontrib><creatorcontrib>Yu, Hongmeng</creatorcontrib><creatorcontrib>Wang, Dehui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wanpeng</au><au>Xu, Rui</au><au>Zhu, Bijun</au><au>Wang, Huan</au><au>Zhang, Huankang</au><au>Hu, Li</au><au>Li, Houyong</au><au>Sun, Xicai</au><au>Yu, Hongmeng</au><au>Wang, Dehui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2022-02</date><risdate>2022</risdate><volume>44</volume><issue>2</issue><spage>494</spage><epage>504</epage><pages>494-504</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate in southern China and Southeast Asia and an evident ethnic and geographical distribution. Circular RNAs (circRNAs) are single‐stranded noncoding RNAs with covalent, closed‐loop structures. They are characterized by high stability and abundance, are evolutionarily conserved, and exhibit tissue/developmental stage specificity. Previous studies have shown that circRNAs are associated with the occurrence and development of various malignant tumors. However, the expression patterns and clinical significance of circRNAs in NPC remain ambiguous. Hence, the present review focuses on the biogenesis and regulation of circRNAs, and the functional roles of abnormally expressed circRNAs in NPC. In addition, the current review discusses the possibility of utilizing circRNAs as potential clinical biomarkers for the diagnosis and prognosis of NPC.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34931399</pmid><doi>10.1002/hed.26962</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0346-3193</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2022-02, Vol.44 (2), p.494-504 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2612387977 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | biogenesis biomarker Biomarkers circRNAs functional mechanism Geographical distribution Humans Mucosa Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - genetics Prognosis RNA, Circular - genetics Throat cancer Tumors |
| title | Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T13%3A32%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circular%20RNAs:%20Functions%20and%20mechanisms%20in%20nasopharyngeal%20carcinoma&rft.jtitle=Head%20&%20neck&rft.au=Li,%20Wanpeng&rft.date=2022-02&rft.volume=44&rft.issue=2&rft.spage=494&rft.epage=504&rft.pages=494-504&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.26962&rft_dat=%3Cproquest_cross%3E2620013932%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2620013932&rft_id=info:pmid/34931399&rfr_iscdi=true |