Overweight or obesity are not risk factors for central venous catheter–related bloodstream infections in patients with hematological malignancies
To the Editor—In 2015, we reported on the risk of central venous catheter (CVC)–related bloodstream infections (CRBSIs) in obese patients with hematological malignancies.1 Considering together definite, probable, and possible CRBSIs,2 we detected no difference in the CRBSI rate between obese and non...
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| Veröffentlicht in: | Infection control and hospital epidemiology 2022-12, Vol.43 (12), p.1953-1955 |
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| description | To the Editor—In 2015, we reported on the risk of central venous catheter (CVC)–related bloodstream infections (CRBSIs) in obese patients with hematological malignancies.1 Considering together definite, probable, and possible CRBSIs,2 we detected no difference in the CRBSI rate between obese and nonobese patients (22.1% vs 23.3%).1 However, this analysis was based on only 335 CVC cases from the Magdeburg cohort of the SECRECY registry (German Clinical Trial Register, no. Patients/CVCs Characteristics and CRBSI Features Parameter Control Cohort (n=347) Overweight Cohort (n=405) Obesity Cohort (n=294) Median BMI, kg/m2 (range) 22 (19–24) 27 (25–29) 33 (30–56) Median age, y (IQR) 55 (40–63) 61 (54–67) 59 (50–64) Sex, male, n/N (%) 198/347 (57.1) 276/405 (68.1) 162/294 (55.1) Underlying diseases, n/N (%) Acute leukemia 209/347 (60.2) 191/405 (47.2) 137/294 (46.6) Lymphoma 63/347 (18.2) 67/405 (16.5) 39/294 (13.3) Multiple myeloma 51/347 (14.7) 118/405 94/294 (32.0) Myeloproliferative neoplasm 1/347 (0.3) (2/405 (0.5)29.1) 0 Myelodysplastic syndrome 2/347 (0.6) 6/405 (1.5) 3/294 (1.0) Others 21/347 (6.1) 21/405 (5.2) 21/294 (7.1) Neutropeniaa at CVC insertion, n/N (%) 79/347 (22.8) 80/405 (19.8) 66/294 (22.4) Neutropeniaa at infection, n/N (%) CRBSIb 23/26 (88.5) 41/49 (83.7) 28/30 (93.3) dCRBSI 7/8 (87.5) 21/23 (91.3) 8/9 (88.9) Chlorhexidine-coated CVC dressing, n/N (%) 340/347 (98.0) 404/405 (99.8) 288/294 (98.0) Antimicrobial-coated CVC, n/N (%) 5/347 (1.4) 3/405 (0.7) 5/294 (1.7) Jugular vein CVC, n/N (%) 339/347 (97.7) 397/405 (98.0) 291/294 (99.0) CVC days, median (IQR) 17 (8–23) 17 (9–21) 14 (7.75–21) Median time to onset, d (IQR) CRBSIb 11 (7.75–16.25) 12 (6–19) 11 (9.75–14.25) dCRBSI 10.5 (6.75–22.25) 12 (10–14) 12 (10–15.5) Infection rate, n/N (%) CRBSIb 26/347 (7.5) 49/405 (12.1) 30/294 (10.2) (P=.04c) (P=.23c) HR, 1.66 (95% CI, 1.03–2.68) HR, 1.26 (95% CI, 0.97–1.64) (P=.04) (P=.09) 23/405 (5.7) 9/294 (3.1) dCRBSI 8/347 (2.3) (P=.02d) (P=.56c) HR, 2.48 (95% CI, 1.11–5.54) HR, 1.26 (95% CI, 0.78–2.03) (P=.03) (P=.35) Infection incidence, x per 1,000 CVC days CRBSIb 4.5 7.4 7.0 (P=.04c) (P=.10c) dCRBSI 1.4 3.5 2.1 (P=.02c) (P=.41c) Causative CRBSI b pathogens, n/N (%) Coagulase-negative staphylococci 22/26 (84.6) 36/49 (73.5) 26/30 (86.7) Enterobacteriaceae 2/26 (7.7) 1/49 (2.0) 0 Other Gram-negative pathogens 0 3/49 (6.1) 0 Other Gram-positive pathogens 2/26 (7.7) 8/49 (16.3) 3/30 (10.0) Multibacterial 0 1/49 (2.0) 1/30 (3.3) The median number of CV |
| doi_str_mv | 10.1017/ice.2021.491 |
| format | Article |
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Patients/CVCs Characteristics and CRBSI Features Parameter Control Cohort (n=347) Overweight Cohort (n=405) Obesity Cohort (n=294) Median BMI, kg/m2 (range) 22 (19–24) 27 (25–29) 33 (30–56) Median age, y (IQR) 55 (40–63) 61 (54–67) 59 (50–64) Sex, male, n/N (%) 198/347 (57.1) 276/405 (68.1) 162/294 (55.1) Underlying diseases, n/N (%) Acute leukemia 209/347 (60.2) 191/405 (47.2) 137/294 (46.6) Lymphoma 63/347 (18.2) 67/405 (16.5) 39/294 (13.3) Multiple myeloma 51/347 (14.7) 118/405 94/294 (32.0) Myeloproliferative neoplasm 1/347 (0.3) (2/405 (0.5)29.1) 0 Myelodysplastic syndrome 2/347 (0.6) 6/405 (1.5) 3/294 (1.0) Others 21/347 (6.1) 21/405 (5.2) 21/294 (7.1) Neutropeniaa at CVC insertion, n/N (%) 79/347 (22.8) 80/405 (19.8) 66/294 (22.4) Neutropeniaa at infection, n/N (%) CRBSIb 23/26 (88.5) 41/49 (83.7) 28/30 (93.3) dCRBSI 7/8 (87.5) 21/23 (91.3) 8/9 (88.9) Chlorhexidine-coated CVC dressing, n/N (%) 340/347 (98.0) 404/405 (99.8) 288/294 (98.0) Antimicrobial-coated CVC, n/N (%) 5/347 (1.4) 3/405 (0.7) 5/294 (1.7) Jugular vein CVC, n/N (%) 339/347 (97.7) 397/405 (98.0) 291/294 (99.0) CVC days, median (IQR) 17 (8–23) 17 (9–21) 14 (7.75–21) Median time to onset, d (IQR) CRBSIb 11 (7.75–16.25) 12 (6–19) 11 (9.75–14.25) dCRBSI 10.5 (6.75–22.25) 12 (10–14) 12 (10–15.5) Infection rate, n/N (%) CRBSIb 26/347 (7.5) 49/405 (12.1) 30/294 (10.2) (P=.04c) (P=.23c) HR, 1.66 (95% CI, 1.03–2.68) HR, 1.26 (95% CI, 0.97–1.64) (P=.04) (P=.09) 23/405 (5.7) 9/294 (3.1) dCRBSI 8/347 (2.3) (P=.02d) (P=.56c) HR, 2.48 (95% CI, 1.11–5.54) HR, 1.26 (95% CI, 0.78–2.03) (P=.03) (P=.35) Infection incidence, x per 1,000 CVC days CRBSIb 4.5 7.4 7.0 (P=.04c) (P=.10c) dCRBSI 1.4 3.5 2.1 (P=.02c) (P=.41c) Causative CRBSI b pathogens, n/N (%) Coagulase-negative staphylococci 22/26 (84.6) 36/49 (73.5) 26/30 (86.7) Enterobacteriaceae 2/26 (7.7) 1/49 (2.0) 0 Other Gram-negative pathogens 0 3/49 (6.1) 0 Other Gram-positive pathogens 2/26 (7.7) 8/49 (16.3) 3/30 (10.0) Multibacterial 0 1/49 (2.0) 1/30 (3.3) The median number of CVC days was lower in obese compared to normal weight or overweight patients (14 vs 17 days). The CRBSI rate was significantly higher in the overweight as compared to the normal weight group (12.1% vs 7.5%; hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.03–2.68; P = .04), whereas it was not significantly different between obese and normal weight patients (10.2% vs 7.5%; HR, 1.26; 95% CI, 0.97–1.64; P = .09).</description><identifier>ISSN: 0899-823X</identifier><identifier>EISSN: 1559-6834</identifier><identifier>DOI: 10.1017/ice.2021.491</identifier><identifier>PMID: 34924070</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Body mass index ; Catheter-Related Infections - etiology ; Catheterization, Central Venous - adverse effects ; Catheters ; Central Venous Catheters - adverse effects ; Hematologic Neoplasms - complications ; Hematology ; Humans ; Infections ; Letter to the Editor ; Leukemia ; Lymphoma ; Medical instruments ; Multiple myeloma ; Neutropenia ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Overweight ; Overweight - complications ; Overweight - epidemiology ; Pathogens ; Patients ; Risk factors ; Sepsis - etiology ; Veins & arteries</subject><ispartof>Infection control and hospital epidemiology, 2022-12, Vol.43 (12), p.1953-1955</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-f38c1d0630cd8005b19aa3c2cc82adc1c5d5afc618fca3cfc3cacdc084afa84f3</citedby><cites>FETCH-LOGICAL-c396t-f38c1d0630cd8005b19aa3c2cc82adc1c5d5afc618fca3cfc3cacdc084afa84f3</cites><orcidid>0000-0003-1892-5098 ; 0000-0001-5622-348X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2753982031/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2753982031?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>164,314,776,780,21368,27903,27904,33723,33724,43784,55606,74048</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34924070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schalk, Enrico</creatorcontrib><creatorcontrib>Hentrich, Marcus</creatorcontrib><title>Overweight or obesity are not risk factors for central venous catheter–related bloodstream infections in patients with hematological malignancies</title><title>Infection control and hospital epidemiology</title><addtitle>Infect. Control Hosp. Epidemiol</addtitle><description>To the Editor—In 2015, we reported on the risk of central venous catheter (CVC)–related bloodstream infections (CRBSIs) in obese patients with hematological malignancies.1 Considering together definite, probable, and possible CRBSIs,2 we detected no difference in the CRBSI rate between obese and nonobese patients (22.1% vs 23.3%).1 However, this analysis was based on only 335 CVC cases from the Magdeburg cohort of the SECRECY registry (German Clinical Trial Register, no. Patients/CVCs Characteristics and CRBSI Features Parameter Control Cohort (n=347) Overweight Cohort (n=405) Obesity Cohort (n=294) Median BMI, kg/m2 (range) 22 (19–24) 27 (25–29) 33 (30–56) Median age, y (IQR) 55 (40–63) 61 (54–67) 59 (50–64) Sex, male, n/N (%) 198/347 (57.1) 276/405 (68.1) 162/294 (55.1) Underlying diseases, n/N (%) Acute leukemia 209/347 (60.2) 191/405 (47.2) 137/294 (46.6) Lymphoma 63/347 (18.2) 67/405 (16.5) 39/294 (13.3) Multiple myeloma 51/347 (14.7) 118/405 94/294 (32.0) Myeloproliferative neoplasm 1/347 (0.3) (2/405 (0.5)29.1) 0 Myelodysplastic syndrome 2/347 (0.6) 6/405 (1.5) 3/294 (1.0) Others 21/347 (6.1) 21/405 (5.2) 21/294 (7.1) Neutropeniaa at CVC insertion, n/N (%) 79/347 (22.8) 80/405 (19.8) 66/294 (22.4) Neutropeniaa at infection, n/N (%) CRBSIb 23/26 (88.5) 41/49 (83.7) 28/30 (93.3) dCRBSI 7/8 (87.5) 21/23 (91.3) 8/9 (88.9) Chlorhexidine-coated CVC dressing, n/N (%) 340/347 (98.0) 404/405 (99.8) 288/294 (98.0) Antimicrobial-coated CVC, n/N (%) 5/347 (1.4) 3/405 (0.7) 5/294 (1.7) Jugular vein CVC, n/N (%) 339/347 (97.7) 397/405 (98.0) 291/294 (99.0) CVC days, median (IQR) 17 (8–23) 17 (9–21) 14 (7.75–21) Median time to onset, d (IQR) CRBSIb 11 (7.75–16.25) 12 (6–19) 11 (9.75–14.25) dCRBSI 10.5 (6.75–22.25) 12 (10–14) 12 (10–15.5) Infection rate, n/N (%) CRBSIb 26/347 (7.5) 49/405 (12.1) 30/294 (10.2) (P=.04c) (P=.23c) HR, 1.66 (95% CI, 1.03–2.68) HR, 1.26 (95% CI, 0.97–1.64) (P=.04) (P=.09) 23/405 (5.7) 9/294 (3.1) dCRBSI 8/347 (2.3) (P=.02d) (P=.56c) HR, 2.48 (95% CI, 1.11–5.54) HR, 1.26 (95% CI, 0.78–2.03) (P=.03) (P=.35) Infection incidence, x per 1,000 CVC days CRBSIb 4.5 7.4 7.0 (P=.04c) (P=.10c) dCRBSI 1.4 3.5 2.1 (P=.02c) (P=.41c) Causative CRBSI b pathogens, n/N (%) Coagulase-negative staphylococci 22/26 (84.6) 36/49 (73.5) 26/30 (86.7) Enterobacteriaceae 2/26 (7.7) 1/49 (2.0) 0 Other Gram-negative pathogens 0 3/49 (6.1) 0 Other Gram-positive pathogens 2/26 (7.7) 8/49 (16.3) 3/30 (10.0) Multibacterial 0 1/49 (2.0) 1/30 (3.3) The median number of CVC days was lower in obese compared to normal weight or overweight patients (14 vs 17 days). The CRBSI rate was significantly higher in the overweight as compared to the normal weight group (12.1% vs 7.5%; hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.03–2.68; P = .04), whereas it was not significantly different between obese and normal weight patients (10.2% vs 7.5%; HR, 1.26; 95% CI, 0.97–1.64; P = .09).</description><subject>Body mass index</subject><subject>Catheter-Related Infections - etiology</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Catheters</subject><subject>Central Venous Catheters - adverse effects</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematology</subject><subject>Humans</subject><subject>Infections</subject><subject>Letter to the Editor</subject><subject>Leukemia</subject><subject>Lymphoma</subject><subject>Medical instruments</subject><subject>Multiple myeloma</subject><subject>Neutropenia</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Overweight</subject><subject>Overweight - complications</subject><subject>Overweight - epidemiology</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Sepsis - etiology</subject><subject>Veins & arteries</subject><issn>0899-823X</issn><issn>1559-6834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkcuKFDEUQIMoTju6cy0BNy6sNo-q6mQpgy8YmI2Cu-LWrZvujFVJm6RnmJ3_MH_ol5hhWgVxlRBOTm44jD2XYi2F3LzxSGsllFy3Vj5gK9l1tumNbh-ylTDWNkbpryfsSc6XQoiNtfIxO9GtVa3YiBW7vbiidE1-uys8Jh5Hyr7ccEjEQyw8-fyNO8ASU-auAkihJJj5FYV4yByh7KhQ-vnjNtEMhSY-zjFOuSSChfvgCIuPIdct30Px9Xrm177s-I4WKHGOW4_Vt8DstwECespP2SMHc6Znx_WUfXn_7vPZx-b84sOns7fnDWrbl8Zpg3ISvRY4GSG6UVoAjQrRKJhQYjd14LCXxmE9d6gRcEJhWnBgWqdP2at77z7F7wfKZVh8RppnCFQ_N6heKqF7pXVFX_6DXsZDCnW6QW06bU0FZaVe31OYYs6J3LBPfoF0M0gx3MUaaqzhLtZQY1X8xVF6GBea_sC_61RgffTBMiY_benvs_81_gLxeKTs</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Schalk, Enrico</creator><creator>Hentrich, Marcus</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>S0X</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1892-5098</orcidid><orcidid>https://orcid.org/0000-0001-5622-348X</orcidid></search><sort><creationdate>20221201</creationdate><title>Overweight or obesity are not risk factors for central venous catheter–related bloodstream infections in patients with hematological malignancies</title><author>Schalk, Enrico ; Hentrich, Marcus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-f38c1d0630cd8005b19aa3c2cc82adc1c5d5afc618fca3cfc3cacdc084afa84f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Body mass index</topic><topic>Catheter-Related Infections - etiology</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Catheters</topic><topic>Central Venous Catheters - adverse effects</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematology</topic><topic>Humans</topic><topic>Infections</topic><topic>Letter to the Editor</topic><topic>Leukemia</topic><topic>Lymphoma</topic><topic>Medical instruments</topic><topic>Multiple myeloma</topic><topic>Neutropenia</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Overweight</topic><topic>Overweight - complications</topic><topic>Overweight - epidemiology</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Sepsis - etiology</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schalk, Enrico</creatorcontrib><creatorcontrib>Hentrich, Marcus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Infection control and hospital epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schalk, Enrico</au><au>Hentrich, Marcus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overweight or obesity are not risk factors for central venous catheter–related bloodstream infections in patients with hematological malignancies</atitle><jtitle>Infection control and hospital epidemiology</jtitle><addtitle>Infect. Control Hosp. Epidemiol</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>43</volume><issue>12</issue><spage>1953</spage><epage>1955</epage><pages>1953-1955</pages><issn>0899-823X</issn><eissn>1559-6834</eissn><abstract>To the Editor—In 2015, we reported on the risk of central venous catheter (CVC)–related bloodstream infections (CRBSIs) in obese patients with hematological malignancies.1 Considering together definite, probable, and possible CRBSIs,2 we detected no difference in the CRBSI rate between obese and nonobese patients (22.1% vs 23.3%).1 However, this analysis was based on only 335 CVC cases from the Magdeburg cohort of the SECRECY registry (German Clinical Trial Register, no. Patients/CVCs Characteristics and CRBSI Features Parameter Control Cohort (n=347) Overweight Cohort (n=405) Obesity Cohort (n=294) Median BMI, kg/m2 (range) 22 (19–24) 27 (25–29) 33 (30–56) Median age, y (IQR) 55 (40–63) 61 (54–67) 59 (50–64) Sex, male, n/N (%) 198/347 (57.1) 276/405 (68.1) 162/294 (55.1) Underlying diseases, n/N (%) Acute leukemia 209/347 (60.2) 191/405 (47.2) 137/294 (46.6) Lymphoma 63/347 (18.2) 67/405 (16.5) 39/294 (13.3) Multiple myeloma 51/347 (14.7) 118/405 94/294 (32.0) Myeloproliferative neoplasm 1/347 (0.3) (2/405 (0.5)29.1) 0 Myelodysplastic syndrome 2/347 (0.6) 6/405 (1.5) 3/294 (1.0) Others 21/347 (6.1) 21/405 (5.2) 21/294 (7.1) Neutropeniaa at CVC insertion, n/N (%) 79/347 (22.8) 80/405 (19.8) 66/294 (22.4) Neutropeniaa at infection, n/N (%) CRBSIb 23/26 (88.5) 41/49 (83.7) 28/30 (93.3) dCRBSI 7/8 (87.5) 21/23 (91.3) 8/9 (88.9) Chlorhexidine-coated CVC dressing, n/N (%) 340/347 (98.0) 404/405 (99.8) 288/294 (98.0) Antimicrobial-coated CVC, n/N (%) 5/347 (1.4) 3/405 (0.7) 5/294 (1.7) Jugular vein CVC, n/N (%) 339/347 (97.7) 397/405 (98.0) 291/294 (99.0) CVC days, median (IQR) 17 (8–23) 17 (9–21) 14 (7.75–21) Median time to onset, d (IQR) CRBSIb 11 (7.75–16.25) 12 (6–19) 11 (9.75–14.25) dCRBSI 10.5 (6.75–22.25) 12 (10–14) 12 (10–15.5) Infection rate, n/N (%) CRBSIb 26/347 (7.5) 49/405 (12.1) 30/294 (10.2) (P=.04c) (P=.23c) HR, 1.66 (95% CI, 1.03–2.68) HR, 1.26 (95% CI, 0.97–1.64) (P=.04) (P=.09) 23/405 (5.7) 9/294 (3.1) dCRBSI 8/347 (2.3) (P=.02d) (P=.56c) HR, 2.48 (95% CI, 1.11–5.54) HR, 1.26 (95% CI, 0.78–2.03) (P=.03) (P=.35) Infection incidence, x per 1,000 CVC days CRBSIb 4.5 7.4 7.0 (P=.04c) (P=.10c) dCRBSI 1.4 3.5 2.1 (P=.02c) (P=.41c) Causative CRBSI b pathogens, n/N (%) Coagulase-negative staphylococci 22/26 (84.6) 36/49 (73.5) 26/30 (86.7) Enterobacteriaceae 2/26 (7.7) 1/49 (2.0) 0 Other Gram-negative pathogens 0 3/49 (6.1) 0 Other Gram-positive pathogens 2/26 (7.7) 8/49 (16.3) 3/30 (10.0) Multibacterial 0 1/49 (2.0) 1/30 (3.3) The median number of CVC days was lower in obese compared to normal weight or overweight patients (14 vs 17 days). The CRBSI rate was significantly higher in the overweight as compared to the normal weight group (12.1% vs 7.5%; hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.03–2.68; P = .04), whereas it was not significantly different between obese and normal weight patients (10.2% vs 7.5%; HR, 1.26; 95% CI, 0.97–1.64; P = .09).</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>34924070</pmid><doi>10.1017/ice.2021.491</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-1892-5098</orcidid><orcidid>https://orcid.org/0000-0001-5622-348X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-823X |
| ispartof | Infection control and hospital epidemiology, 2022-12, Vol.43 (12), p.1953-1955 |
| issn | 0899-823X 1559-6834 |
| language | eng |
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| source | MEDLINE; ProQuest Central; Cambridge University Press Journals Complete |
| subjects | Body mass index Catheter-Related Infections - etiology Catheterization, Central Venous - adverse effects Catheters Central Venous Catheters - adverse effects Hematologic Neoplasms - complications Hematology Humans Infections Letter to the Editor Leukemia Lymphoma Medical instruments Multiple myeloma Neutropenia Obesity Obesity - complications Obesity - epidemiology Overweight Overweight - complications Overweight - epidemiology Pathogens Patients Risk factors Sepsis - etiology Veins & arteries |
| title | Overweight or obesity are not risk factors for central venous catheter–related bloodstream infections in patients with hematological malignancies |
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