DNA-Encoded Multivalent Display of Chemically Modified Protein Tetramers on Phage: Synthesis and in Vivo Applications

Phage display links the phenotype of displayed polypeptides with the DNA sequence in the phage genome and offers a universal method for the discovery of proteins with novel properties. However, the display of large multisubunit proteins on phages remains a challenge. A majority of protein display sy...

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Veröffentlicht in:	ACS chemical biology 2022-11, Vol.17 (11), p.3024-3035
Hauptverfasser:	Lima, Guilherme M., Atrazhev, Alexey, Sarkar, Susmita, Sojitra, Mirat, Reddy, Revathi, Torres-Obreque, Karin, de Oliveira Rangel-Yagui, Carlota, Macauley, Matthew S., Monteiro, Gisele, Derda, Ratmir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asparaginase - genetics Bacteriophage M13 - genetics Bacteriophage M13 - metabolism Bacteriophages - genetics Cell Surface Display Techniques DNA - metabolism Mice Peptide Library Proteins - metabolism
Online-Zugang:	Volltext
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