Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells

Radiation-induced esophagitis, experienced during radiation therapy for lung cancer and head and neck cancer, is a major dose-limiting side effect of the treatment. This study aimed to elucidate the role of interferon-α (IFN-α) in radiation-induced esophagitis. C57BL/6 mice were exposed to 10 and 25...

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Veröffentlicht in:	Life sciences (1973) 2022-01, Vol.289, p.120215-120215, Article 120215
Hauptverfasser:	Kitamura, Hiroyuki, Tanigawa, Tetsuya, Kuzumoto, Takuya, Nadatani, Yuji, Otani, Koji, Fukunaga, Shusei, Hosomi, Shuhei, Tanaka, Fumio, Kamata, Noriko, Nagami, Yasuaki, Taira, Koichi, Uematsu, Satoshi, Watanabe, Toshio, Fujiwara, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Bortezomib Chemokines Cytokines Dendritic cells Dendritic Cells - immunology Depletion DNA damage Epithelial cells Epithelium Esophagitis Esophagitis - etiology Esophagitis - immunology Esophagus Gamma Rays - adverse effects Gene expression Head & neck cancer Inactivation Inflammation Interferon Interferon-alpha - immunology Interferon-α Irradiation Lung cancer Male Mice Mucosa Plasmacytoid dendritic cells Poly (ADP-ribose) polymerase Radiation Radiation damage Radiation effects Radiation Injuries, Experimental - immunology Radiation therapy Radiotherapy - adverse effects Thickness Thorax α-Interferon
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