Signal-On Electrochemical Detection for Drug-Resistant Hepatitis B Virus Mutants through Three-Way Junction Transduction and Exonuclease III-Assisted Catalyzed Hairpin Assembly

The present detection method for hepatitis B virus (HBV) drug-resistant mutation has a high misdiagnosis rate and usually needs to meet stringent requirements for technology and equipment, leading to complex and time-consuming manipulation and drawback of high costs. Herein, with the purpose of deve...

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Veröffentlicht in:	Analytical chemistry (Washington) 2022-01, Vol.94 (2), p.600-605
Hauptverfasser:	Yu, Jiaxue, Liu, Jingju, Ma, Chong-Bo, Qi, Lijuan, Du, Yan, Hu, Xintong, Jiang, Yanfang, Zhou, Ming, Wang, Erkang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Assembly Biosensing Techniques - methods Catalysis Chemistry Diagnosis DNA - genetics Drug resistance Electrochemical analysis Electrochemistry Exodeoxyribonucleases Exonuclease Hepatitis Hepatitis B Hepatitis B virus - genetics Mutation Noise sensitivity Nucleic Acid Amplification Techniques - methods Nucleic acids Resistant mutant RNA-directed DNA polymerase Signal to noise ratio Transduction
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