Vitamin D is directly associated with favorable glycemic, lipid, and inflammatory profiles in individuals with at least one component of metabolic syndrome irrespective of total adiposity: Pró-Saúde Study, Brazil
Vitamin D insufficiency has been suggested as a risk factor for several metabolic disorders. The objective of the study was to investigate the association between serum 25 hydroxyvitamin D [25(OH)D] and metabolic health markers of Brazilian individuals with normal-weight, overweight or obesity. We h...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2021-12, Vol.96, p.1-8 |
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| creator | Oliveira, Mitsu A. Faerstein, Eduardo Koury, Josely C. Pereira-Manfro, Wânia F. Milagres, Lucimar G. Neto, José Firmino N. Bezerra, Flávia F. |
| description | Vitamin D insufficiency has been suggested as a risk factor for several metabolic disorders. The objective of the study was to investigate the association between serum 25 hydroxyvitamin D [25(OH)D] and metabolic health markers of Brazilian individuals with normal-weight, overweight or obesity. We hypothesized that serum 25(OH)D would be inversely associated with glycemic, lipid and inflammatory markers indicative of metabolic abnormality. Data of 511 individuals (33-79 years), recruited from a longitudinal investigation (Pró-Saúde Study), were analyzed cross-sectionally. Anthropometric, biochemical, body composition, socio-demographic and lifestyle data were collected. Based on body mass index (BMI; normal weight, overweight, obesity) and metabolic health (metabolically healthy (MH) and metabolically unhealthy (MU)) categories, the participants were classified into 6 phenotypes. Individuals having zero components of the metabolic syndrome were considered as “MH”. MH obesity was frequent in 2.0% of the participants and 56.0% exhibited vitamin D insufficiency ( |
| doi_str_mv | 10.1016/j.nutres.2021.10.002 |
| format | Article |
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The objective of the study was to investigate the association between serum 25 hydroxyvitamin D [25(OH)D] and metabolic health markers of Brazilian individuals with normal-weight, overweight or obesity. We hypothesized that serum 25(OH)D would be inversely associated with glycemic, lipid and inflammatory markers indicative of metabolic abnormality. Data of 511 individuals (33-79 years), recruited from a longitudinal investigation (Pró-Saúde Study), were analyzed cross-sectionally. Anthropometric, biochemical, body composition, socio-demographic and lifestyle data were collected. Based on body mass index (BMI; normal weight, overweight, obesity) and metabolic health (metabolically healthy (MH) and metabolically unhealthy (MU)) categories, the participants were classified into 6 phenotypes. Individuals having zero components of the metabolic syndrome were considered as “MH”. MH obesity was frequent in 2.0% of the participants and 56.0% exhibited vitamin D insufficiency (<20 ng/mL). In the subgroups of the same BMI category, there were no significant differences in 25(OH)D concentrations between individuals classified as MH and MU. After adjustments (including %body fat and BMI), an inverse association was observed between 25(OH)D and visceral adipose tissue (B = -6.46, 95% confidence interval, CI: -12.87, -0.04), leptin (B = -0.09, 95% confidence interval, CI: -0.14, -0.03), insulin (B = -0.21, 95%CI: -0.34, -0.07), HOMA-IR (B = -0.06, 95%CI: -0.10, -0.02), triglycerides (B = -2.44, 95%CI: -3.66, -1.22), and TNF-α (B = -0.12, 95%CI: -0.24, -0.005) only in MU individuals. Our results indicate that the association of 25(OH)D concentrations with a favorable biochemical profile (glycemic, lipidic and inflammatory) seems to depend on the individual's overall metabolic health, suggesting more benefits from higher serum vitamin D in MU individuals, regardless of their adiposity.</description><identifier>ISSN: 0271-5317</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2021.10.002</identifier><identifier>PMID: 34890855</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>25-hydroxycholecalciferol ; Adipokines ; Adiposity ; Body Mass Index ; Brazil ; Calcifediol ; Humans ; Inflammation markers ; Metabolic health ; Metabolic Syndrome ; Metabolically healthy obesity ; Obesity - complications ; Vitamin D ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - epidemiology</subject><ispartof>Nutrition research (New York, N.Y.), 2021-12, Vol.96, p.1-8</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-20db85836ca620120574ecc5ae7ba0a746418cd2690ed407a56357f6d56f36743</citedby><cites>FETCH-LOGICAL-c362t-20db85836ca620120574ecc5ae7ba0a746418cd2690ed407a56357f6d56f36743</cites><orcidid>0000-0003-0166-8144 ; 0000-0001-5696-8158 ; 0000-0002-6594-4323</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.nutres.2021.10.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34890855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Mitsu A.</creatorcontrib><creatorcontrib>Faerstein, Eduardo</creatorcontrib><creatorcontrib>Koury, Josely C.</creatorcontrib><creatorcontrib>Pereira-Manfro, Wânia F.</creatorcontrib><creatorcontrib>Milagres, Lucimar G.</creatorcontrib><creatorcontrib>Neto, José Firmino N.</creatorcontrib><creatorcontrib>Bezerra, Flávia F.</creatorcontrib><title>Vitamin D is directly associated with favorable glycemic, lipid, and inflammatory profiles in individuals with at least one component of metabolic syndrome irrespective of total adiposity: Pró-Saúde Study, Brazil</title><title>Nutrition research (New York, N.Y.)</title><addtitle>Nutr Res</addtitle><description>Vitamin D insufficiency has been suggested as a risk factor for several metabolic disorders. The objective of the study was to investigate the association between serum 25 hydroxyvitamin D [25(OH)D] and metabolic health markers of Brazilian individuals with normal-weight, overweight or obesity. We hypothesized that serum 25(OH)D would be inversely associated with glycemic, lipid and inflammatory markers indicative of metabolic abnormality. Data of 511 individuals (33-79 years), recruited from a longitudinal investigation (Pró-Saúde Study), were analyzed cross-sectionally. Anthropometric, biochemical, body composition, socio-demographic and lifestyle data were collected. Based on body mass index (BMI; normal weight, overweight, obesity) and metabolic health (metabolically healthy (MH) and metabolically unhealthy (MU)) categories, the participants were classified into 6 phenotypes. Individuals having zero components of the metabolic syndrome were considered as “MH”. MH obesity was frequent in 2.0% of the participants and 56.0% exhibited vitamin D insufficiency (<20 ng/mL). In the subgroups of the same BMI category, there were no significant differences in 25(OH)D concentrations between individuals classified as MH and MU. After adjustments (including %body fat and BMI), an inverse association was observed between 25(OH)D and visceral adipose tissue (B = -6.46, 95% confidence interval, CI: -12.87, -0.04), leptin (B = -0.09, 95% confidence interval, CI: -0.14, -0.03), insulin (B = -0.21, 95%CI: -0.34, -0.07), HOMA-IR (B = -0.06, 95%CI: -0.10, -0.02), triglycerides (B = -2.44, 95%CI: -3.66, -1.22), and TNF-α (B = -0.12, 95%CI: -0.24, -0.005) only in MU individuals. Our results indicate that the association of 25(OH)D concentrations with a favorable biochemical profile (glycemic, lipidic and inflammatory) seems to depend on the individual's overall metabolic health, suggesting more benefits from higher serum vitamin D in MU individuals, regardless of their adiposity.</description><subject>25-hydroxycholecalciferol</subject><subject>Adipokines</subject><subject>Adiposity</subject><subject>Body Mass Index</subject><subject>Brazil</subject><subject>Calcifediol</subject><subject>Humans</subject><subject>Inflammation markers</subject><subject>Metabolic health</subject><subject>Metabolic Syndrome</subject><subject>Metabolically healthy obesity</subject><subject>Obesity - complications</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>0271-5317</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-K1TAUxosoznX0DUSydHF7Tdom7XUh6PgXBhRG3ZbT5FTPJW1qkl6pr-XO7byDz2MuHV0KgUM-vvPn45dlDwXfCS7Uk8NunKPHsCt4IZK047y4lW1EU-9zXpf729mGF7XIZSnqs-xeCAfORS3K8m52VlbNnjdSbrLfnynCQCN7ySgwQx51tAuDEJwmiGjYd4pfWQ9H56GzyL7YReNAesssTWS2DEbDaOwtDANE5xc2edeTxZDU9AwdycxgwzoIIrMIITI3ItNumFId069nA0bonCXNwjIa7wZk5FO-KV1ERzxZootgGRiaXKC4PGUf_PXP_AqufxlkV3E2y5a98PCD7P3sTp924oObep59ev3q48Xb_PL9m3cXzy9zXaoi5gU3XSObUmlQBRcFl3WFWkvAugMOdaUq0WhTqD1HU_EapCpl3SsjVV-quirPs8fr3BT624whtgMFjdbCiG4ObaGEULJqSpms1WrV3oXgsW8nTwP4pRW8PRFtD-1KtD0RPamJaGp7dLNh7gY0_5r-IkyGZ6sBU84joW-DJhw1rjBb4-j_G_4A2Je6Yw</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Oliveira, Mitsu A.</creator><creator>Faerstein, Eduardo</creator><creator>Koury, Josely C.</creator><creator>Pereira-Manfro, Wânia F.</creator><creator>Milagres, Lucimar G.</creator><creator>Neto, José Firmino N.</creator><creator>Bezerra, Flávia F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0166-8144</orcidid><orcidid>https://orcid.org/0000-0001-5696-8158</orcidid><orcidid>https://orcid.org/0000-0002-6594-4323</orcidid></search><sort><creationdate>202112</creationdate><title>Vitamin D is directly associated with favorable glycemic, lipid, and inflammatory profiles in individuals with at least one component of metabolic syndrome irrespective of total adiposity: Pró-Saúde Study, Brazil</title><author>Oliveira, Mitsu A. ; Faerstein, Eduardo ; Koury, Josely C. ; Pereira-Manfro, Wânia F. ; Milagres, Lucimar G. ; Neto, José Firmino N. ; Bezerra, Flávia F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-20db85836ca620120574ecc5ae7ba0a746418cd2690ed407a56357f6d56f36743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>25-hydroxycholecalciferol</topic><topic>Adipokines</topic><topic>Adiposity</topic><topic>Body Mass Index</topic><topic>Brazil</topic><topic>Calcifediol</topic><topic>Humans</topic><topic>Inflammation markers</topic><topic>Metabolic health</topic><topic>Metabolic Syndrome</topic><topic>Metabolically healthy obesity</topic><topic>Obesity - complications</topic><topic>Vitamin D</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Mitsu A.</creatorcontrib><creatorcontrib>Faerstein, Eduardo</creatorcontrib><creatorcontrib>Koury, Josely C.</creatorcontrib><creatorcontrib>Pereira-Manfro, Wânia F.</creatorcontrib><creatorcontrib>Milagres, Lucimar G.</creatorcontrib><creatorcontrib>Neto, José Firmino N.</creatorcontrib><creatorcontrib>Bezerra, Flávia F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Mitsu A.</au><au>Faerstein, Eduardo</au><au>Koury, Josely C.</au><au>Pereira-Manfro, Wânia F.</au><au>Milagres, Lucimar G.</au><au>Neto, José Firmino N.</au><au>Bezerra, Flávia F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D is directly associated with favorable glycemic, lipid, and inflammatory profiles in individuals with at least one component of metabolic syndrome irrespective of total adiposity: Pró-Saúde Study, Brazil</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2021-12</date><risdate>2021</risdate><volume>96</volume><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0271-5317</issn><eissn>1879-0739</eissn><abstract>Vitamin D insufficiency has been suggested as a risk factor for several metabolic disorders. The objective of the study was to investigate the association between serum 25 hydroxyvitamin D [25(OH)D] and metabolic health markers of Brazilian individuals with normal-weight, overweight or obesity. We hypothesized that serum 25(OH)D would be inversely associated with glycemic, lipid and inflammatory markers indicative of metabolic abnormality. Data of 511 individuals (33-79 years), recruited from a longitudinal investigation (Pró-Saúde Study), were analyzed cross-sectionally. Anthropometric, biochemical, body composition, socio-demographic and lifestyle data were collected. Based on body mass index (BMI; normal weight, overweight, obesity) and metabolic health (metabolically healthy (MH) and metabolically unhealthy (MU)) categories, the participants were classified into 6 phenotypes. Individuals having zero components of the metabolic syndrome were considered as “MH”. MH obesity was frequent in 2.0% of the participants and 56.0% exhibited vitamin D insufficiency (<20 ng/mL). In the subgroups of the same BMI category, there were no significant differences in 25(OH)D concentrations between individuals classified as MH and MU. After adjustments (including %body fat and BMI), an inverse association was observed between 25(OH)D and visceral adipose tissue (B = -6.46, 95% confidence interval, CI: -12.87, -0.04), leptin (B = -0.09, 95% confidence interval, CI: -0.14, -0.03), insulin (B = -0.21, 95%CI: -0.34, -0.07), HOMA-IR (B = -0.06, 95%CI: -0.10, -0.02), triglycerides (B = -2.44, 95%CI: -3.66, -1.22), and TNF-α (B = -0.12, 95%CI: -0.24, -0.005) only in MU individuals. Our results indicate that the association of 25(OH)D concentrations with a favorable biochemical profile (glycemic, lipidic and inflammatory) seems to depend on the individual's overall metabolic health, suggesting more benefits from higher serum vitamin D in MU individuals, regardless of their adiposity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34890855</pmid><doi>10.1016/j.nutres.2021.10.002</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0166-8144</orcidid><orcidid>https://orcid.org/0000-0001-5696-8158</orcidid><orcidid>https://orcid.org/0000-0002-6594-4323</orcidid></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 25-hydroxycholecalciferol Adipokines Adiposity Body Mass Index Brazil Calcifediol Humans Inflammation markers Metabolic health Metabolic Syndrome Metabolically healthy obesity Obesity - complications Vitamin D Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology |
| title | Vitamin D is directly associated with favorable glycemic, lipid, and inflammatory profiles in individuals with at least one component of metabolic syndrome irrespective of total adiposity: Pró-Saúde Study, Brazil |
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