Generation of bispecific antibodies using chemical conjugation methods

Bispecific antibodies combine the specificity of two antibodies into one molecule. During the past two decades, advancement in protein engineering enabled the development of more than 100 bispecific formats, three of which are approved by the FDA for clinical use. In parallel to protein engineering...

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Veröffentlicht in:	Drug discovery today. Technologies 2021-12, Vol.40, p.13-24
Hauptverfasser:	Dimasi, Nazzareno, Kumar, Amit, Gao, Changshou
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bispecific
Online-Zugang:	Volltext
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