Spectrum of height in patients with celiac disease
Background Growth retardation is an important feature of celiac disease (CeD) that can lead to the failure of attainment of potential adult height. There is lack of data on the spectrum of height in treatment-naïve patients with CeD, with normal expected height at one end and short stature at the ot...
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| Veröffentlicht in: | Indian journal of gastroenterology 2021-12, Vol.40 (6), p.604-612 |
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| creator | Aggarwal, Nishant Dwarakanathan, Vignesh Singh, Alka Agarwal, Ashish Khuttan, Akhilesh Ahmed, Anam Rajput, Mahendra Singh Chauhan, Ashish Banyal, Vikas Verma, Anil K. Gupta, Vipin Lodha, Rakesh Ahuja, Vineet Makharia, Govind K. |
| description | Background
Growth retardation is an important feature of celiac disease (CeD) that can lead to the failure of attainment of potential adult height. There is lack of data on the spectrum of height in treatment-naïve patients with CeD, with normal expected height at one end and short stature at the other.
Methods
We performed a retrospective analysis of a prospectively maintained database at our center, including a total of 583 treatment-naïve patients with CeD: 419 adults (183 [43.7%] males) and 164 adolescents (12–18 years) (72 [43.9%] males). The details extracted from the database included demographic details, height, weight, body mass index, clinical symptoms, biochemical parameters, anti-tissue transglutaminase antibody anti-tTG Ab) titer, and the severity of villous abnormalities (as per modified Marsh grade). The data from Indian National Family Health Survey-4 were used as comparators.
Results
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While mean height of men with CeD was similar, women were taller than population controls. While a higher proportion of men with CeD had short stature as compared to the controls (32.2% vs. 20%,
p |
| doi_str_mv | 10.1007/s12664-021-01173-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2611653287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2611653287</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-290ca3b3bb4f4291951beb71262f7b5ae3884c5bfc823df933539ce1ee765b923</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwAyxQlmwMfsR2vEQVL6kSC2Bt2e6kddUmwU6E-HtcUliymhnNnas7B6FLSm4oIeo2USZliQmjmFCqONZHaEq0EpgoSo9zz0SJq0qSCTpLaUP2s-anaMJLzaiUZIrYawe-j8OuaOtiDWG17ovQFJ3tAzR9Kj5Dvy48bIP1xTIksAnO0UlttwkuDnWG3h_u3-ZPePHy-Dy_W2DPS9Vjpom33HHnyrpkmmpBHTiVM7NaOWGBV1Xphat9xfiy1pwLrj1QACWF04zP0PXo28X2Y4DUm11IOcrWNtAOyTBJqRScVSpL2Sj1sU0pQm26GHY2fhlKzJ6VGVmZzMr8sDI6H10d_Ae3g-XfyS-cLOCjIOVVs4JoNu0Qm_zzf7bfx1RzGw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2611653287</pqid></control><display><type>article</type><title>Spectrum of height in patients with celiac disease</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Aggarwal, Nishant ; Dwarakanathan, Vignesh ; Singh, Alka ; Agarwal, Ashish ; Khuttan, Akhilesh ; Ahmed, Anam ; Rajput, Mahendra Singh ; Chauhan, Ashish ; Banyal, Vikas ; Verma, Anil K. ; Gupta, Vipin ; Lodha, Rakesh ; Ahuja, Vineet ; Makharia, Govind K.</creator><creatorcontrib>Aggarwal, Nishant ; Dwarakanathan, Vignesh ; Singh, Alka ; Agarwal, Ashish ; Khuttan, Akhilesh ; Ahmed, Anam ; Rajput, Mahendra Singh ; Chauhan, Ashish ; Banyal, Vikas ; Verma, Anil K. ; Gupta, Vipin ; Lodha, Rakesh ; Ahuja, Vineet ; Makharia, Govind K.</creatorcontrib><description>Background
Growth retardation is an important feature of celiac disease (CeD) that can lead to the failure of attainment of potential adult height. There is lack of data on the spectrum of height in treatment-naïve patients with CeD, with normal expected height at one end and short stature at the other.
Methods
We performed a retrospective analysis of a prospectively maintained database at our center, including a total of 583 treatment-naïve patients with CeD: 419 adults (183 [43.7%] males) and 164 adolescents (12–18 years) (72 [43.9%] males). The details extracted from the database included demographic details, height, weight, body mass index, clinical symptoms, biochemical parameters, anti-tissue transglutaminase antibody anti-tTG Ab) titer, and the severity of villous abnormalities (as per modified Marsh grade). The data from Indian National Family Health Survey-4 were used as comparators.
Results
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While mean height of men with CeD was similar, women were taller than population controls. While a higher proportion of men with CeD had short stature as compared to the controls (32.2% vs. 20%,
p
<0.001), a lower proportion of women with CeD had short stature (9.7% vs. 18.9%,
p
<0.001). Higher proportion of adolescents with CeD had short stature compared to adults (57.9% vs. 19.6%,
p
<0.001). On multivariate analysis, adulthood was found to be associated with a lower prevalence of short stature.
Conclusions
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While the mean height of adult men with CeD was not significantly different from the population controls, women were taller. Adolescents with CeD were significantly shorter than their peers.</description><identifier>ISSN: 0254-8860</identifier><identifier>EISSN: 0975-0711</identifier><identifier>DOI: 10.1007/s12664-021-01173-9</identifier><identifier>PMID: 34921660</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adolescent ; Adult ; Autoantibodies ; Body Mass Index ; Celiac Disease - diagnosis ; Female ; Gastroenterology ; Hepatology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Retrospective Studies</subject><ispartof>Indian journal of gastroenterology, 2021-12, Vol.40 (6), p.604-612</ispartof><rights>Indian Society of Gastroenterology 2021</rights><rights>2021. Indian Society of Gastroenterology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-290ca3b3bb4f4291951beb71262f7b5ae3884c5bfc823df933539ce1ee765b923</citedby><cites>FETCH-LOGICAL-c347t-290ca3b3bb4f4291951beb71262f7b5ae3884c5bfc823df933539ce1ee765b923</cites><orcidid>0000-0002-2474-2194</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12664-021-01173-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12664-021-01173-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34921660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aggarwal, Nishant</creatorcontrib><creatorcontrib>Dwarakanathan, Vignesh</creatorcontrib><creatorcontrib>Singh, Alka</creatorcontrib><creatorcontrib>Agarwal, Ashish</creatorcontrib><creatorcontrib>Khuttan, Akhilesh</creatorcontrib><creatorcontrib>Ahmed, Anam</creatorcontrib><creatorcontrib>Rajput, Mahendra Singh</creatorcontrib><creatorcontrib>Chauhan, Ashish</creatorcontrib><creatorcontrib>Banyal, Vikas</creatorcontrib><creatorcontrib>Verma, Anil K.</creatorcontrib><creatorcontrib>Gupta, Vipin</creatorcontrib><creatorcontrib>Lodha, Rakesh</creatorcontrib><creatorcontrib>Ahuja, Vineet</creatorcontrib><creatorcontrib>Makharia, Govind K.</creatorcontrib><title>Spectrum of height in patients with celiac disease</title><title>Indian journal of gastroenterology</title><addtitle>Indian J Gastroenterol</addtitle><addtitle>Indian J Gastroenterol</addtitle><description>Background
Growth retardation is an important feature of celiac disease (CeD) that can lead to the failure of attainment of potential adult height. There is lack of data on the spectrum of height in treatment-naïve patients with CeD, with normal expected height at one end and short stature at the other.
Methods
We performed a retrospective analysis of a prospectively maintained database at our center, including a total of 583 treatment-naïve patients with CeD: 419 adults (183 [43.7%] males) and 164 adolescents (12–18 years) (72 [43.9%] males). The details extracted from the database included demographic details, height, weight, body mass index, clinical symptoms, biochemical parameters, anti-tissue transglutaminase antibody anti-tTG Ab) titer, and the severity of villous abnormalities (as per modified Marsh grade). The data from Indian National Family Health Survey-4 were used as comparators.
Results
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While mean height of men with CeD was similar, women were taller than population controls. While a higher proportion of men with CeD had short stature as compared to the controls (32.2% vs. 20%,
p
<0.001), a lower proportion of women with CeD had short stature (9.7% vs. 18.9%,
p
<0.001). Higher proportion of adolescents with CeD had short stature compared to adults (57.9% vs. 19.6%,
p
<0.001). On multivariate analysis, adulthood was found to be associated with a lower prevalence of short stature.
Conclusions
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While the mean height of adult men with CeD was not significantly different from the population controls, women were taller. Adolescents with CeD were significantly shorter than their peers.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autoantibodies</subject><subject>Body Mass Index</subject><subject>Celiac Disease - diagnosis</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><issn>0254-8860</issn><issn>0975-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyxQlmwMfsR2vEQVL6kSC2Bt2e6kddUmwU6E-HtcUliymhnNnas7B6FLSm4oIeo2USZliQmjmFCqONZHaEq0EpgoSo9zz0SJq0qSCTpLaUP2s-anaMJLzaiUZIrYawe-j8OuaOtiDWG17ovQFJ3tAzR9Kj5Dvy48bIP1xTIksAnO0UlttwkuDnWG3h_u3-ZPePHy-Dy_W2DPS9Vjpom33HHnyrpkmmpBHTiVM7NaOWGBV1Xphat9xfiy1pwLrj1QACWF04zP0PXo28X2Y4DUm11IOcrWNtAOyTBJqRScVSpL2Sj1sU0pQm26GHY2fhlKzJ6VGVmZzMr8sDI6H10d_Ae3g-XfyS-cLOCjIOVVs4JoNu0Qm_zzf7bfx1RzGw</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Aggarwal, Nishant</creator><creator>Dwarakanathan, Vignesh</creator><creator>Singh, Alka</creator><creator>Agarwal, Ashish</creator><creator>Khuttan, Akhilesh</creator><creator>Ahmed, Anam</creator><creator>Rajput, Mahendra Singh</creator><creator>Chauhan, Ashish</creator><creator>Banyal, Vikas</creator><creator>Verma, Anil K.</creator><creator>Gupta, Vipin</creator><creator>Lodha, Rakesh</creator><creator>Ahuja, Vineet</creator><creator>Makharia, Govind K.</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2474-2194</orcidid></search><sort><creationdate>20211201</creationdate><title>Spectrum of height in patients with celiac disease</title><author>Aggarwal, Nishant ; Dwarakanathan, Vignesh ; Singh, Alka ; Agarwal, Ashish ; Khuttan, Akhilesh ; Ahmed, Anam ; Rajput, Mahendra Singh ; Chauhan, Ashish ; Banyal, Vikas ; Verma, Anil K. ; Gupta, Vipin ; Lodha, Rakesh ; Ahuja, Vineet ; Makharia, Govind K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-290ca3b3bb4f4291951beb71262f7b5ae3884c5bfc823df933539ce1ee765b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autoantibodies</topic><topic>Body Mass Index</topic><topic>Celiac Disease - diagnosis</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aggarwal, Nishant</creatorcontrib><creatorcontrib>Dwarakanathan, Vignesh</creatorcontrib><creatorcontrib>Singh, Alka</creatorcontrib><creatorcontrib>Agarwal, Ashish</creatorcontrib><creatorcontrib>Khuttan, Akhilesh</creatorcontrib><creatorcontrib>Ahmed, Anam</creatorcontrib><creatorcontrib>Rajput, Mahendra Singh</creatorcontrib><creatorcontrib>Chauhan, Ashish</creatorcontrib><creatorcontrib>Banyal, Vikas</creatorcontrib><creatorcontrib>Verma, Anil K.</creatorcontrib><creatorcontrib>Gupta, Vipin</creatorcontrib><creatorcontrib>Lodha, Rakesh</creatorcontrib><creatorcontrib>Ahuja, Vineet</creatorcontrib><creatorcontrib>Makharia, Govind K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aggarwal, Nishant</au><au>Dwarakanathan, Vignesh</au><au>Singh, Alka</au><au>Agarwal, Ashish</au><au>Khuttan, Akhilesh</au><au>Ahmed, Anam</au><au>Rajput, Mahendra Singh</au><au>Chauhan, Ashish</au><au>Banyal, Vikas</au><au>Verma, Anil K.</au><au>Gupta, Vipin</au><au>Lodha, Rakesh</au><au>Ahuja, Vineet</au><au>Makharia, Govind K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrum of height in patients with celiac disease</atitle><jtitle>Indian journal of gastroenterology</jtitle><stitle>Indian J Gastroenterol</stitle><addtitle>Indian J Gastroenterol</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>40</volume><issue>6</issue><spage>604</spage><epage>612</epage><pages>604-612</pages><issn>0254-8860</issn><eissn>0975-0711</eissn><abstract>Background
Growth retardation is an important feature of celiac disease (CeD) that can lead to the failure of attainment of potential adult height. There is lack of data on the spectrum of height in treatment-naïve patients with CeD, with normal expected height at one end and short stature at the other.
Methods
We performed a retrospective analysis of a prospectively maintained database at our center, including a total of 583 treatment-naïve patients with CeD: 419 adults (183 [43.7%] males) and 164 adolescents (12–18 years) (72 [43.9%] males). The details extracted from the database included demographic details, height, weight, body mass index, clinical symptoms, biochemical parameters, anti-tissue transglutaminase antibody anti-tTG Ab) titer, and the severity of villous abnormalities (as per modified Marsh grade). The data from Indian National Family Health Survey-4 were used as comparators.
Results
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While mean height of men with CeD was similar, women were taller than population controls. While a higher proportion of men with CeD had short stature as compared to the controls (32.2% vs. 20%,
p
<0.001), a lower proportion of women with CeD had short stature (9.7% vs. 18.9%,
p
<0.001). Higher proportion of adolescents with CeD had short stature compared to adults (57.9% vs. 19.6%,
p
<0.001). On multivariate analysis, adulthood was found to be associated with a lower prevalence of short stature.
Conclusions
Overall, 19.6% of adults and 57.9% of adolescents with CeD had short stature. While the mean height of adult men with CeD was not significantly different from the population controls, women were taller. Adolescents with CeD were significantly shorter than their peers.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>34921660</pmid><doi>10.1007/s12664-021-01173-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2474-2194</orcidid></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Autoantibodies Body Mass Index Celiac Disease - diagnosis Female Gastroenterology Hepatology Humans Male Medicine Medicine & Public Health Original Article Retrospective Studies |
| title | Spectrum of height in patients with celiac disease |
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