Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

In murine models, microbial exposures induce protection from experimental allergic asthma through innate immunity. Our aim was to assess the association of early life innate immunity with the development of asthma in children at risk. In the PASTURE farm birth cohort, innate T-helper cell type 2 (Th...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2022-03, Vol.205 (6), p.641-650
Hauptverfasser:	Illi, Sabina, Depner, Martin, Pfefferle, Petra Ina, Renz, Harald, Roduit, Caroline, Taft, Diana Hazard, Kalanetra, Karen M, Mills, David A, Farquharson, Freda M, Louis, Petra, Schmausser-Hechfellner, Elisabeth, Divaret-Chauveau, Amandine, Lauener, Roger, Karvonen, Anne M, Pekkanen, Juha, Kirjavainen, Pirkka V, Roponen, Marjut, Riedler, Josef, Kabesch, Michael, Schaub, Bianca, von Mutius, Erika
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Alleles Animals Asthma Asthma - genetics Cattle Children & youth Chromosomes, Human, Pair 17 Cytokines Cytokines - genetics Female Humans Immunity, Innate Leukocytes, Mononuclear Lipopolysaccharides Mice Respiratory Sounds - genetics Risk factors
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