Investigation of Physical Properties of Disodium Etidronate Tetrahydrate and Application of Phosphorus K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy

Purpose Disodium etidronate is a bisphosphonate, compounds that are widely used in the treatment of bone disorders such as osteoporosis and Paget’s disease. We investigated the physical properties of disodium etidronate tetrahydrate crystal, form I. Methods We used X-ray powder diffraction (XRPD), t...

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Veröffentlicht in:	Pharmaceutical research 2021-12, Vol.38 (12), p.2147-2155
Hauptverfasser:	Ito, Naoya, Hashizuka, Takahiko, Ito, Masataka, Suzuki, Hironori, Noguchi, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Bone diseases Care and treatment Chemistry, Pharmaceutical - methods Crystal structure Crystals Diffraction Drug Compounding Etidronic acid Etidronic Acid - chemistry Investigations Medical Law Medical research Medicine, Experimental Osteoporosis Pharmacology/Toxicology Pharmacy Phosphates Phosphorus Phosphorus - chemistry Physical properties Relative humidity Research Paper Spectroscopy Spectrum analysis Structure X-Ray Absorption Spectroscopy X-Ray Diffraction X-rays
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