Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs

Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between MM cells and bone marrow (BM) fibroblasts (FBs). During monoclonal gammopathy of undetermined significance (MGUS) to MM transition, MM cell‐derived exosomes (EXOs) reprogram the miRNA (miR) profile of FBs, inducing...

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Veröffentlicht in:	The Journal of pathology 2022-04, Vol.256 (4), p.402-413
Hauptverfasser:	Saltarella, Ilaria, Lamanuzzi, Aurelia, Desantis, Vanessa, Di Marzo, Lucia, Melaccio, Assunta, Curci, Paola, Annese, Tiziana, Nico, Beatrice, Solimando, Antonio Giovanni, Bartoli, Giulia, Tolomeo, Doron, Storlazzi, Clelia Tiziana, Mariggiò, Maria Addolorata, Ria, Roberto, Musto, Pellegrino, Vacca, Angelo, Frassanito, Maria Antonia
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis Benign monoclonal gammopathy Bone marrow Bortezomib Cell proliferation Drug resistance Exosomes Exosomes - pathology Fibroblasts Fibroblasts - pathology Humans lncRNAs MAP kinase MicroRNAs - genetics MicroRNAs - metabolism miRNA miRNAs Multiple myeloma Multiple Myeloma - pathology Non-coding RNA p53 Protein Phosphatidylinositol 3-Kinases - metabolism PTEN protein RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism TOR protein Transfection Tumors tumour microenvironment
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