Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease

BackgroundThe aim of this study is to identify differentially methylated regions (DMRs) in the genomes of a sample of cognitively healthy individuals and a sample of individuals with LOAD, all of them nonagenarians from Costa Rica.MethodsIn this study, we compared whole blood DNA methylation profile...

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Veröffentlicht in:	CNS spectrums 2023-04, Vol.28 (2), p.174-182
Hauptverfasser:	Coto-Vílchez, Carolina, Martínez-Magaña, José J., Mora-Villalobos, Lara, Valerio, Daniel, Genis-Mendoza, Alma D., Silverman, Jeremy M., Nicolini, Humberto, Raventós, Henriette, Chavarria-Soley, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Alzheimer's disease Brain research Cognitive ability Consent Dementia DNA methylation Epigenetics Genomes Hormone replacement therapy Original Research Quality control Risk factors
Online-Zugang:	Volltext
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