Tissue compartmentalization enables Salmonella persistence during chemotherapy

Antimicrobial chemotherapy can fail to eradicate the pathogen, even in the absence of antimicrobial resistance. Persisting pathogens can subsequently cause relapsing diseases. In vitro studies suggest various mechanisms of antibiotic persistence, but their in vivo relevance remains unclear because o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-12, Vol.118 (51), p.1-12, Article 2113951118
Hauptverfasser:	Li, Jiagui, Claudi, Beatrice, Fanous, Joseph, Chicherova, Natalia, Cianfanelli, Francesca Romana, Campbell, Robert A. A., Bumann, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Antimicrobial resistance Biological Sciences Chemotherapy Clearances Colonization Drug tolerance Enrofloxacin - therapeutic use In vivo methods and tests Inflammation Leukocytes (neutrophilic) Mice Mice, Inbred BALB C Monocytes Multidisciplinary Sciences Pathogens Salmonella Salmonella Infections, Animal - drug therapy Salmonella Infections, Animal - microbiology Salmonella typhimurium - drug effects Salmonella typhimurium - physiology Science & Technology Science & Technology - Other Topics Spleen Tissues White pulp
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