TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription

Protein lysine 2-hydroxyisobutyrylation (Khib) has recently been shown to play a critical role in the regulation of cellular processes. However, the mechanism and functional consequence of Khib in prokaryotes remain unclear. Here we report that TmcA, an RNA acetyltransferase, functions as a lysine 2...

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Veröffentlicht in:	Nature chemical biology 2022-02, Vol.18 (2), p.142-151
Hauptverfasser:	Dong, Hanyang, Zhao, Yujie, Bi, Changfen, Han, Yue, Zhang, Jianji, Bai, Xue, Zhai, Guijin, Zhang, Hui, Tian, Shanshan, Hu, Deqing, Xu, Liyan, Zhang, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 631/45/475/2290 631/92/458 Acetyltransferase Acetyltransferases - genetics Acetyltransferases - metabolism Acid resistance Acids Amino Acid Sequence Biochemical Engineering Biochemistry Bioorganic Chemistry Catalysis Catalytic activity Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fimbriae Proteins - genetics Fimbriae Proteins - metabolism Gene Expression Regulation, Bacterial - physiology Gene Expression Regulation, Enzymologic - physiology Gene regulation Lysine Models, Molecular Prokaryotes Protein Binding Protein Conformation Proteins Proteomics Ribonucleic acid RNA Stress, Physiological Transcription Transcription, Genetic Transcriptome
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