High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy

Depression is one of the most common mental illnesses in modern society. In recent years, several studies show that there are disturbances in lipid metabolism in depressed patients. High-fat diet may lead to anxiety and depression, but the mechanisms involved remain unclear. In our study, we found t...

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Veröffentlicht in:	Experimental neurology 2022-02, Vol.348, p.113949-113949, Article 113949
Hauptverfasser:	Li, Yong, Cheng, Yujie, Zhou, Yuan, Du, Hongmei, Zhang, Cui, Zhao, Zhentao, Chen, Yuenan, Zhou, Zhongnan, Mei, Jinyu, Wu, Wenning, Chen, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPK/mTOR Animals Anxiety - metabolism Anxiety - psychology Autophagy Autophagy - physiology Body Weight - physiology Depression Depression - metabolism Depression - psychology Diet, High-Fat - adverse effects High fat diet Lipid Metabolism - physiology Male Maze Learning - physiology Mice Mice, Inbred C57BL Obesity Obesity - metabolism Obesity - psychology Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
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