Mucocutaneous mycoses in people living with human immunodeficiency virus in Indonesia
Background To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifesta...
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| Veröffentlicht in: | Mycoses 2022-03, Vol.65 (3), p.323-330 |
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| container_title | Mycoses |
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| creator | Widaty, Sandra Oktarina, Caroline Suling, Pieter Levinus Niode, Nurdjannah Jane Miranda, Eliza Andriani, Anni Amin, Safruddin Yenny, Satya Widya Bramono, Kusmarinah |
| description | Background
To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.
Objectives
To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population and its associated factors in Indonesia.
Methods
This retrospective study was conducted from January 2014 to December 2018 in four academic hospitals. Data were acquired from medical records with the inclusion of mucocutaneous mycosis patients with concurrent HIV infection. Analysis with the chi‐squared test was performed using Statistical Package for the Social Sciences (SPSS) version 20.0.
Results
A total of 1,796 cases of mucocutaneous mycoses were identified in 1782 PLHIV. The most common types of infection were candidiasis (63%), followed by dermatophytosis (35.1%), and malasseziosis (1.9%), which were significantly higher in PLHIV with CD4 level |
| doi_str_mv | 10.1111/myc.13414 |
| format | Article |
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To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.
Objectives
To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population and its associated factors in Indonesia.
Methods
This retrospective study was conducted from January 2014 to December 2018 in four academic hospitals. Data were acquired from medical records with the inclusion of mucocutaneous mycosis patients with concurrent HIV infection. Analysis with the chi‐squared test was performed using Statistical Package for the Social Sciences (SPSS) version 20.0.
Results
A total of 1,796 cases of mucocutaneous mycoses were identified in 1782 PLHIV. The most common types of infection were candidiasis (63%), followed by dermatophytosis (35.1%), and malasseziosis (1.9%), which were significantly higher in PLHIV with CD4 level <200 cells/mm3. The proportions of male gender (78.6% vs. 56.3%, p < .001), high level of education (48.0% vs. 64.1%, p < .001), office workers (73.8% vs. 64.1%, p < .001), combination of topical and systemic antifungal agents (59.1% vs. 48.5%, p = .006) and not receiving antiretroviral therapy (63.2% vs. 7.8%, p < .001) were significantly higher in PLHIV with a CD4 level <200 cells/mm3.
Conclusion
In Indonesia, the most common fungal infection in PLHIV is candidiasis. This study also addressed the important matters regarding mucocutaneous mycoses in PLHIV. Education is an important measure to prevent the incidence of cutaneous mycoses in PLHIV, especially in high‐risk groups.]]></description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/myc.13414</identifier><identifier>PMID: 34902221</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>AIDS ; Antifungal agents ; Antiretroviral therapy ; Candidiasis ; CD4 ; CD4 antigen ; Dermatomycoses - complications ; Dermatomycoses - drug therapy ; Dermatomycoses - epidemiology ; Dermatomycosis ; fungal infection ; Fungal infections ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Immune system ; Immunocompromised hosts ; Indonesia - epidemiology ; Male ; Medical records ; mucocutaneous mycosis ; Mycosis ; Patients ; Retrospective Studies ; Risk groups</subject><ispartof>Mycoses, 2022-03, Vol.65 (3), p.323-330</ispartof><rights>2021 Wiley‐VCH GmbH.</rights><rights>2021 Wiley-VCH GmbH.</rights><rights>2022 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3134-7037e33246e9eed81025ecd1c65da560fe24ce9294ce3f1ddf726ae4e476efff3</cites><orcidid>0000-0002-7347-8959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmyc.13414$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmyc.13414$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34902221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Widaty, Sandra</creatorcontrib><creatorcontrib>Oktarina, Caroline</creatorcontrib><creatorcontrib>Suling, Pieter Levinus</creatorcontrib><creatorcontrib>Niode, Nurdjannah Jane</creatorcontrib><creatorcontrib>Miranda, Eliza</creatorcontrib><creatorcontrib>Andriani, Anni</creatorcontrib><creatorcontrib>Amin, Safruddin</creatorcontrib><creatorcontrib>Yenny, Satya Widya</creatorcontrib><creatorcontrib>Bramono, Kusmarinah</creatorcontrib><title>Mucocutaneous mycoses in people living with human immunodeficiency virus in Indonesia</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description><![CDATA[Background
To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.
Objectives
To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population and its associated factors in Indonesia.
Methods
This retrospective study was conducted from January 2014 to December 2018 in four academic hospitals. Data were acquired from medical records with the inclusion of mucocutaneous mycosis patients with concurrent HIV infection. Analysis with the chi‐squared test was performed using Statistical Package for the Social Sciences (SPSS) version 20.0.
Results
A total of 1,796 cases of mucocutaneous mycoses were identified in 1782 PLHIV. The most common types of infection were candidiasis (63%), followed by dermatophytosis (35.1%), and malasseziosis (1.9%), which were significantly higher in PLHIV with CD4 level <200 cells/mm3. The proportions of male gender (78.6% vs. 56.3%, p < .001), high level of education (48.0% vs. 64.1%, p < .001), office workers (73.8% vs. 64.1%, p < .001), combination of topical and systemic antifungal agents (59.1% vs. 48.5%, p = .006) and not receiving antiretroviral therapy (63.2% vs. 7.8%, p < .001) were significantly higher in PLHIV with a CD4 level <200 cells/mm3.
Conclusion
In Indonesia, the most common fungal infection in PLHIV is candidiasis. This study also addressed the important matters regarding mucocutaneous mycoses in PLHIV. Education is an important measure to prevent the incidence of cutaneous mycoses in PLHIV, especially in high‐risk groups.]]></description><subject>AIDS</subject><subject>Antifungal agents</subject><subject>Antiretroviral therapy</subject><subject>Candidiasis</subject><subject>CD4</subject><subject>CD4 antigen</subject><subject>Dermatomycoses - complications</subject><subject>Dermatomycoses - drug therapy</subject><subject>Dermatomycoses - epidemiology</subject><subject>Dermatomycosis</subject><subject>fungal infection</subject><subject>Fungal infections</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunocompromised hosts</subject><subject>Indonesia - epidemiology</subject><subject>Male</subject><subject>Medical records</subject><subject>mucocutaneous mycosis</subject><subject>Mycosis</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk groups</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAUQC0EoqUw8AMoEgsMaf1K3Iyo4iW1YqEDUxSca-oqsUNct8rfY5rCgIQHezk-uvcgdEnwmIQzqTs5JowTfoSGhLMsxgkWx2iIM8ZiwbEYoDPn1hgTkdH0FA0YzzCllAzRcuGllX5TGLDeRcFkHbhIm6gB21QQVXqrzUe005tVtPJ1YSJd197YEpSWGozsoq1u_f7LsymtAaeLc3SiisrBxeEdoeXD_evsKZ6_PD7P7uaxZGHeWGAmgDHKU8gAyinBNAFZEpkmZZGkWAHlEjKahZspUpZK0LQADlykoJRiI3TTe5vWfnpwm7zWTkJV9evkNCUYCz4NHUbo-g-6tr41YbpAMUwJz6Y0ULc9JVvrXAsqb1pdF22XE5x_t85DoXzfOrBXB6N_r6H8JX_iBmDSAztdQfe_KV-8zXrlF4YkiRg</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Widaty, Sandra</creator><creator>Oktarina, Caroline</creator><creator>Suling, Pieter Levinus</creator><creator>Niode, Nurdjannah Jane</creator><creator>Miranda, Eliza</creator><creator>Andriani, Anni</creator><creator>Amin, Safruddin</creator><creator>Yenny, Satya Widya</creator><creator>Bramono, Kusmarinah</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7347-8959</orcidid></search><sort><creationdate>202203</creationdate><title>Mucocutaneous mycoses in people living with human immunodeficiency virus in Indonesia</title><author>Widaty, Sandra ; Oktarina, Caroline ; Suling, Pieter Levinus ; Niode, Nurdjannah Jane ; Miranda, Eliza ; Andriani, Anni ; Amin, Safruddin ; Yenny, Satya Widya ; Bramono, Kusmarinah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3134-7037e33246e9eed81025ecd1c65da560fe24ce9294ce3f1ddf726ae4e476efff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>AIDS</topic><topic>Antifungal agents</topic><topic>Antiretroviral therapy</topic><topic>Candidiasis</topic><topic>CD4</topic><topic>CD4 antigen</topic><topic>Dermatomycoses - complications</topic><topic>Dermatomycoses - drug therapy</topic><topic>Dermatomycoses - epidemiology</topic><topic>Dermatomycosis</topic><topic>fungal infection</topic><topic>Fungal infections</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunocompromised hosts</topic><topic>Indonesia - epidemiology</topic><topic>Male</topic><topic>Medical records</topic><topic>mucocutaneous mycosis</topic><topic>Mycosis</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Risk groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Widaty, Sandra</creatorcontrib><creatorcontrib>Oktarina, Caroline</creatorcontrib><creatorcontrib>Suling, Pieter Levinus</creatorcontrib><creatorcontrib>Niode, Nurdjannah Jane</creatorcontrib><creatorcontrib>Miranda, Eliza</creatorcontrib><creatorcontrib>Andriani, Anni</creatorcontrib><creatorcontrib>Amin, Safruddin</creatorcontrib><creatorcontrib>Yenny, Satya Widya</creatorcontrib><creatorcontrib>Bramono, Kusmarinah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Widaty, Sandra</au><au>Oktarina, Caroline</au><au>Suling, Pieter Levinus</au><au>Niode, Nurdjannah Jane</au><au>Miranda, Eliza</au><au>Andriani, Anni</au><au>Amin, Safruddin</au><au>Yenny, Satya Widya</au><au>Bramono, Kusmarinah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucocutaneous mycoses in people living with human immunodeficiency virus in Indonesia</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2022-03</date><risdate>2022</risdate><volume>65</volume><issue>3</issue><spage>323</spage><epage>330</epage><pages>323-330</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract><![CDATA[Background
To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.
Objectives
To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population and its associated factors in Indonesia.
Methods
This retrospective study was conducted from January 2014 to December 2018 in four academic hospitals. Data were acquired from medical records with the inclusion of mucocutaneous mycosis patients with concurrent HIV infection. Analysis with the chi‐squared test was performed using Statistical Package for the Social Sciences (SPSS) version 20.0.
Results
A total of 1,796 cases of mucocutaneous mycoses were identified in 1782 PLHIV. The most common types of infection were candidiasis (63%), followed by dermatophytosis (35.1%), and malasseziosis (1.9%), which were significantly higher in PLHIV with CD4 level <200 cells/mm3. The proportions of male gender (78.6% vs. 56.3%, p < .001), high level of education (48.0% vs. 64.1%, p < .001), office workers (73.8% vs. 64.1%, p < .001), combination of topical and systemic antifungal agents (59.1% vs. 48.5%, p = .006) and not receiving antiretroviral therapy (63.2% vs. 7.8%, p < .001) were significantly higher in PLHIV with a CD4 level <200 cells/mm3.
Conclusion
In Indonesia, the most common fungal infection in PLHIV is candidiasis. This study also addressed the important matters regarding mucocutaneous mycoses in PLHIV. Education is an important measure to prevent the incidence of cutaneous mycoses in PLHIV, especially in high‐risk groups.]]></abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34902221</pmid><doi>10.1111/myc.13414</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7347-8959</orcidid></addata></record> |
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| identifier | ISSN: 0933-7407 |
| ispartof | Mycoses, 2022-03, Vol.65 (3), p.323-330 |
| issn | 0933-7407 1439-0507 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | AIDS Antifungal agents Antiretroviral therapy Candidiasis CD4 CD4 antigen Dermatomycoses - complications Dermatomycoses - drug therapy Dermatomycoses - epidemiology Dermatomycosis fungal infection Fungal infections HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Humans Immune system Immunocompromised hosts Indonesia - epidemiology Male Medical records mucocutaneous mycosis Mycosis Patients Retrospective Studies Risk groups |
| title | Mucocutaneous mycoses in people living with human immunodeficiency virus in Indonesia |
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