Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent inhibitors require a high reactive warhead that may...
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Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2022-12, Vol.37 (1), p.226-235 |
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Hauptverfasser: | , , , , , , , , , , |
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Sprache: | eng |
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