A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer
Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Obesity has been proven to be closely related to colorectal carcinogenesis. This review summarized the potential underlying mechanisms linking obesity to CRC in different aspects, including energy metabolism, inflammation,...
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| Veröffentlicht in: | Pharmacological research 2022-01, Vol.175, p.106031-106031, Article 106031 |
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| container_title | Pharmacological research |
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| creator | Yang, Huihai Yue, Grace Gar Lee Leung, Ping Chung Wong, Chun Kwok Lau, Clara Bik San |
| description | Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Obesity has been proven to be closely related to colorectal carcinogenesis. This review summarized the potential underlying mechanisms linking obesity to CRC in different aspects, including energy metabolism, inflammation, activities of adipokines and hormones. Furthermore, the potential therapeutic targets of obesity-associated CRC were predicted using network-based target analysis, with total predicted pathways not only containing previously reported pathways, but also putative signaling pathways pending for investigation. In addition, the current conventional therapeutic treatment options, plus the potential use of herbs and natural products in the management of obesity-associated CRC were also discussed. Taken together, the aim of this review article is to provide strong theoretical basis for future drug development, particularly herbs and natural products, in obesity-associated CRC.
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| doi_str_mv | 10.1016/j.phrs.2021.106031 |
| format | Article |
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[Display omitted]</description><subject>Animals</subject><subject>Biological Products - therapeutic use</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Conventional medicines</subject><subject>Herbs</subject><subject>Humans</subject><subject>Natural products</subject><subject>Network pharmacology</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - drug therapy</subject><subject>Obesity-associated colorectal cancer</subject><subject>Phytotherapy</subject><subject>Target prediction</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAUtBCIlsIPsEBesiAXP3LdRGJTVbykSmxgbZ3Yx72-SuJgO1T9Lz6Qk97CkoVla87M6HiGsddS7KSQ5v1xtxxy2SmhJAFGaPmEnUvRm0bKzjzd3q1ujJHdGXtRylEI0bdSPGdnuu16s2_VOft9xTP-injH08zrAfmURnTrCJlP6A4wxzKVdw8TOhkWXGt0vGaEOuFceZzduPo43z5wllQJjDDyFDjxh8Jh9nyGumYCl5z86ioZbmiFfIuVQPTR1UgLkCgNWGK9b6CU5CJU9NylMWV0lQwczA7zS_YswFjw1eN9wX58-vj9-ktz8-3z1-urm8bpvakNmgGVHkSgZAaQAUE5FbSQTnuEMHjVw170HRqz7zF4mmkIqITQur1sB33B3p58ae-fK5Zqp1gcjiPMmNZilaFATSu6S6KqE9XlVErGYJccJ8j3Vgq7tWWPdmvLbm3ZU1skevPovw4T-n-Sv_UQ4cOJgPRLainb4iJSBD5ugVif4v_8_wCZk6uC</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Yang, Huihai</creator><creator>Yue, Grace Gar Lee</creator><creator>Leung, Ping Chung</creator><creator>Wong, Chun Kwok</creator><creator>Lau, Clara Bik San</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202201</creationdate><title>A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer</title><author>Yang, Huihai ; Yue, Grace Gar Lee ; Leung, Ping Chung ; Wong, Chun Kwok ; Lau, Clara Bik San</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e6be23b0f031ba1fea2c2f301c3deafbd29a5098e6659efd2f33afe20033474b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Biological Products - therapeutic use</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - etiology</topic><topic>Conventional medicines</topic><topic>Herbs</topic><topic>Humans</topic><topic>Natural products</topic><topic>Network pharmacology</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - drug therapy</topic><topic>Obesity-associated colorectal cancer</topic><topic>Phytotherapy</topic><topic>Target prediction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Huihai</creatorcontrib><creatorcontrib>Yue, Grace Gar Lee</creatorcontrib><creatorcontrib>Leung, Ping Chung</creatorcontrib><creatorcontrib>Wong, Chun Kwok</creatorcontrib><creatorcontrib>Lau, Clara Bik San</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Huihai</au><au>Yue, Grace Gar Lee</au><au>Leung, Ping Chung</au><au>Wong, Chun Kwok</au><au>Lau, Clara Bik San</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2022-01</date><risdate>2022</risdate><volume>175</volume><spage>106031</spage><epage>106031</epage><pages>106031-106031</pages><artnum>106031</artnum><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Obesity has been proven to be closely related to colorectal carcinogenesis. This review summarized the potential underlying mechanisms linking obesity to CRC in different aspects, including energy metabolism, inflammation, activities of adipokines and hormones. Furthermore, the potential therapeutic targets of obesity-associated CRC were predicted using network-based target analysis, with total predicted pathways not only containing previously reported pathways, but also putative signaling pathways pending for investigation. In addition, the current conventional therapeutic treatment options, plus the potential use of herbs and natural products in the management of obesity-associated CRC were also discussed. Taken together, the aim of this review article is to provide strong theoretical basis for future drug development, particularly herbs and natural products, in obesity-associated CRC.
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| ispartof | Pharmacological research, 2022-01, Vol.175, p.106031-106031, Article 106031 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological Products - therapeutic use Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - etiology Conventional medicines Herbs Humans Natural products Network pharmacology Obesity Obesity - complications Obesity - drug therapy Obesity-associated colorectal cancer Phytotherapy Target prediction |
| title | A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer |
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