Procollagen I N-terminal peptide correlates with inflammation on sacroiliac joint magnetic resonance imaging in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis: A cross-sectional study

Procollagen I N-terminal peptide correlates with inflammation on sacroiliac joint magnetic resonance imaging in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis: A cross-sectional study

To identify disease activity scores and biomarkers that reflect magnetic resonance imaging (MRI)-determined sacroiliac joint (SIJ) inflammation in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients who had AS and nr-axSpA were enrolled. All the patients und...

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Veröffentlicht in:Modern rheumatology 2022-07, Vol.32 (4), p.770-775
Hauptverfasser: Li, Xuegang, Liang, Anqi, Chen, Yufeng, Lam, Nelson SiuKei, Long, Xinxin, Xu, Xianghe, Zhong, Shuping
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container_issue 4
container_start_page 770
container_title Modern rheumatology
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creator Li, Xuegang
Liang, Anqi
Chen, Yufeng
Lam, Nelson SiuKei
Long, Xinxin
Xu, Xianghe
Zhong, Shuping
description To identify disease activity scores and biomarkers that reflect magnetic resonance imaging (MRI)-determined sacroiliac joint (SIJ) inflammation in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients who had AS and nr-axSpA were enrolled. All the patients underwent SIJ MRI. SpondyloArthritis Research Consortium of Canada (SPARCC) method was used to score bone marrow edema in the inflammatory lesions on MRI. Radiographic assessment of the spine was performed using modified Stoke Ankylosing Spondylitis Spine Score. Clinical variables, inflammatory markers, serum alkaline phosphatase, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX-I), and procollagen I N-terminal peptide (PINP) were measured. Correlation analysis between MRI-determined SIJ inflammation scores and disease activity scores and laboratory variables was performed. Thirty-five patients had AS and 36had nr-axSpA. Significant differences were noted between the AS group and the nr-axSpA group in terms of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Ankylosing Spondylitis Disease Activity Score (ASDAS)-ESR, ASDAS-CRP, PINP, and SPARCC (p 
doi_str_mv 10.1093/mr/roab044
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Patients who had AS and nr-axSpA were enrolled. All the patients underwent SIJ MRI. SpondyloArthritis Research Consortium of Canada (SPARCC) method was used to score bone marrow edema in the inflammatory lesions on MRI. Radiographic assessment of the spine was performed using modified Stoke Ankylosing Spondylitis Spine Score. Clinical variables, inflammatory markers, serum alkaline phosphatase, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX-I), and procollagen I N-terminal peptide (PINP) were measured. Correlation analysis between MRI-determined SIJ inflammation scores and disease activity scores and laboratory variables was performed. Thirty-five patients had AS and 36had nr-axSpA. Significant differences were noted between the AS group and the nr-axSpA group in terms of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Ankylosing Spondylitis Disease Activity Score (ASDAS)-ESR, ASDAS-CRP, PINP, and SPARCC (p < .001, p = .004, p < .001, p < .001, p = .030, p < .001, respectively). MRI-determined SIJ inflammatory scores correlated with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), OC, CTX-I, and PINP in AS (p = .036, p = .023, p = .002, p = .041, p = .004, respectively) and correlated with ESR, CRP, ASDAS-ESR, ASDAS-CRP, BASDAI, and BASFI in nr-axSpA (p = .003, p = .002, p < .001, p < .001, p = .010, p = .007, respectively). Multivariate analysis showed that PINP exhibited a positive correlation independent of the MRI inflammatory score and that age exhibited a negative correlation independent of the MRI inflammatory score. In AS, PINP and age independently correlated with active inflammation on SIJ MRI. PINP may be useful as a marker of objective inflammation in AS.]]></description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.1093/mr/roab044</identifier><identifier>PMID: 34897520</identifier><language>eng</language><publisher>England</publisher><ispartof>Modern rheumatology, 2022-07, Vol.32 (4), p.770-775</ispartof><rights>Japan College of Rheumatology 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-1c1c0ad8fb03e8f09d78500f5c566ba3ee62693ea70991b7278217e1467183583</citedby><cites>FETCH-LOGICAL-c287t-1c1c0ad8fb03e8f09d78500f5c566ba3ee62693ea70991b7278217e1467183583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34897520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xuegang</creatorcontrib><creatorcontrib>Liang, Anqi</creatorcontrib><creatorcontrib>Chen, Yufeng</creatorcontrib><creatorcontrib>Lam, Nelson SiuKei</creatorcontrib><creatorcontrib>Long, Xinxin</creatorcontrib><creatorcontrib>Xu, Xianghe</creatorcontrib><creatorcontrib>Zhong, Shuping</creatorcontrib><title>Procollagen I N-terminal peptide correlates with inflammation on sacroiliac joint magnetic resonance imaging in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis: A cross-sectional study</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description><![CDATA[To identify disease activity scores and biomarkers that reflect magnetic resonance imaging (MRI)-determined sacroiliac joint (SIJ) inflammation in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients who had AS and nr-axSpA were enrolled. All the patients underwent SIJ MRI. SpondyloArthritis Research Consortium of Canada (SPARCC) method was used to score bone marrow edema in the inflammatory lesions on MRI. Radiographic assessment of the spine was performed using modified Stoke Ankylosing Spondylitis Spine Score. Clinical variables, inflammatory markers, serum alkaline phosphatase, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX-I), and procollagen I N-terminal peptide (PINP) were measured. Correlation analysis between MRI-determined SIJ inflammation scores and disease activity scores and laboratory variables was performed. Thirty-five patients had AS and 36had nr-axSpA. Significant differences were noted between the AS group and the nr-axSpA group in terms of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Ankylosing Spondylitis Disease Activity Score (ASDAS)-ESR, ASDAS-CRP, PINP, and SPARCC (p < .001, p = .004, p < .001, p < .001, p = .030, p < .001, respectively). MRI-determined SIJ inflammatory scores correlated with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), OC, CTX-I, and PINP in AS (p = .036, p = .023, p = .002, p = .041, p = .004, respectively) and correlated with ESR, CRP, ASDAS-ESR, ASDAS-CRP, BASDAI, and BASFI in nr-axSpA (p = .003, p = .002, p < .001, p < .001, p = .010, p = .007, respectively). Multivariate analysis showed that PINP exhibited a positive correlation independent of the MRI inflammatory score and that age exhibited a negative correlation independent of the MRI inflammatory score. In AS, PINP and age independently correlated with active inflammation on SIJ MRI. PINP may be useful as a marker of objective inflammation in AS.]]></description><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNo9kc1u1TAQhS1ERUthwwMgLxFSqB3HccyuqvipVNEuYB1NnMm9Lo4dbEdwn7MvhENvkSyNPfrm-GgOIW84-8CZFhdzvIgBBtY0z8gZb4SuVMv086e71PKUvEzpnjEhdadfkFPRdFrJmp2Rh7sYTHAOdujpNf1WZYyz9eDogku2I1ITYkQHGRP9bfOeWj85mGfINnhaTgITg3UWDL0P1mc6w85jtoZGTMGDN0ht6Vm_K7MU_M-DC2l7pSX48eBstokOa6Y-5I3wwVcRRht2EZZ90YE_tvg50gFi3sdt5iO9pOXrlKqEZnOzQXkdD6_IyQQu4etjPSc_Pn_6fvW1urn9cn11eVOZulO54oYbBmM3DUxgNzE9qk4yNkkj23YAgdjWrRYIimnNB1WrruYKedMq3gnZiXPy7lF3ieHXiin3s00GyzI9hjX1dUmhkUrwtqDvH9F_hiNO_RLLUuKh56zfQuzn2B9DLPDbo-46zDj-R59SE38BCLOfUA</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Li, Xuegang</creator><creator>Liang, Anqi</creator><creator>Chen, Yufeng</creator><creator>Lam, Nelson SiuKei</creator><creator>Long, Xinxin</creator><creator>Xu, Xianghe</creator><creator>Zhong, Shuping</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220701</creationdate><title>Procollagen I N-terminal peptide correlates with inflammation on sacroiliac joint magnetic resonance imaging in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis: A cross-sectional study</title><author>Li, Xuegang ; Liang, Anqi ; Chen, Yufeng ; Lam, Nelson SiuKei ; Long, Xinxin ; Xu, Xianghe ; Zhong, Shuping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-1c1c0ad8fb03e8f09d78500f5c566ba3ee62693ea70991b7278217e1467183583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xuegang</creatorcontrib><creatorcontrib>Liang, Anqi</creatorcontrib><creatorcontrib>Chen, Yufeng</creatorcontrib><creatorcontrib>Lam, Nelson SiuKei</creatorcontrib><creatorcontrib>Long, Xinxin</creatorcontrib><creatorcontrib>Xu, Xianghe</creatorcontrib><creatorcontrib>Zhong, Shuping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xuegang</au><au>Liang, Anqi</au><au>Chen, Yufeng</au><au>Lam, Nelson SiuKei</au><au>Long, Xinxin</au><au>Xu, Xianghe</au><au>Zhong, Shuping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Procollagen I N-terminal peptide correlates with inflammation on sacroiliac joint magnetic resonance imaging in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis: A cross-sectional study</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>32</volume><issue>4</issue><spage>770</spage><epage>775</epage><pages>770-775</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract><![CDATA[To identify disease activity scores and biomarkers that reflect magnetic resonance imaging (MRI)-determined sacroiliac joint (SIJ) inflammation in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients who had AS and nr-axSpA were enrolled. All the patients underwent SIJ MRI. SpondyloArthritis Research Consortium of Canada (SPARCC) method was used to score bone marrow edema in the inflammatory lesions on MRI. Radiographic assessment of the spine was performed using modified Stoke Ankylosing Spondylitis Spine Score. Clinical variables, inflammatory markers, serum alkaline phosphatase, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX-I), and procollagen I N-terminal peptide (PINP) were measured. Correlation analysis between MRI-determined SIJ inflammation scores and disease activity scores and laboratory variables was performed. Thirty-five patients had AS and 36had nr-axSpA. Significant differences were noted between the AS group and the nr-axSpA group in terms of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Ankylosing Spondylitis Disease Activity Score (ASDAS)-ESR, ASDAS-CRP, PINP, and SPARCC (p < .001, p = .004, p < .001, p < .001, p = .030, p < .001, respectively). MRI-determined SIJ inflammatory scores correlated with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), OC, CTX-I, and PINP in AS (p = .036, p = .023, p = .002, p = .041, p = .004, respectively) and correlated with ESR, CRP, ASDAS-ESR, ASDAS-CRP, BASDAI, and BASFI in nr-axSpA (p = .003, p = .002, p < .001, p < .001, p = .010, p = .007, respectively). Multivariate analysis showed that PINP exhibited a positive correlation independent of the MRI inflammatory score and that age exhibited a negative correlation independent of the MRI inflammatory score. In AS, PINP and age independently correlated with active inflammation on SIJ MRI. PINP may be useful as a marker of objective inflammation in AS.]]></abstract><cop>England</cop><pmid>34897520</pmid><doi>10.1093/mr/roab044</doi><tpages>6</tpages></addata></record>
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title Procollagen I N-terminal peptide correlates with inflammation on sacroiliac joint magnetic resonance imaging in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis: A cross-sectional study
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