Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing
This work aims to fabricate multifunctional hemostatic sponges (C-ODs). Porous C-ODs were first constructed by using capric acid-modified chitosan (CSCA) and oxidized dextrans (ODs) with different oxidation degrees. Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-...
Gespeichert in:
| Veröffentlicht in: | Carbohydrate polymers 2022-02, Vol.277, p.118782-118782, Article 118782 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 118782 |
|---|---|
| container_issue | |
| container_start_page | 118782 |
| container_title | Carbohydrate polymers |
| container_volume | 277 |
| creator | Wang, Xiaoyu Dang, Qifeng Liu, Chengsheng Chang, Guozhu Song, Hao Xu, Qing Ma, Yue Li, Boyuan Zhang, Bonian Cha, Dongsu |
| description | This work aims to fabricate multifunctional hemostatic sponges (C-ODs). Porous C-ODs were first constructed by using capric acid-modified chitosan (CSCA) and oxidized dextrans (ODs) with different oxidation degrees. Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100–200 μm in pore size) were synthesized, evidenced by FT-IR, 1H NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2's dynamic blood clotting was within 30 s. In three animal injury models, C-OD2's hemostasis time and blood loss were fairly lower than commercial gelatin sponge. Totally, C-OD2 might serve as an ideal hemostatic dressing.
[Display omitted] |
| doi_str_mv | 10.1016/j.carbpol.2021.118782 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2609456635</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0144861721011693</els_id><sourcerecordid>2609456635</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-daa6cb7267889316c751ddc87a0434f11f9e1d316c11fa492ebb41e8109c3f493</originalsourceid><addsrcrecordid>eNqFkMFu1DAQhi1URLeFRwD52EsWT-I4yamqqtJWqsQFztbEnux6lY2D7S0F8fA42i1XfBl75p8Z_x9jH0GsQYD6vFsbDP3sx3UpSlgDtE1bvmGrHLsCKinP2EqAlEWroDlnFzHuRD4KxDt2Xsm2q0poV-zPzZRcjyZRcDjy2Qd_iDzOftoQH7APzmAiy3-6tOUG5_zmaJwtNgGHpWC2LvmIE8fJcv_irPuds5ZeUliSkSOf_DONfEt7HxOmPMAGitFNm_fs7YBjpA-neMm-f7n7dvtQPH29f7y9eSpMpepUWERl-qZUTZu_Dco0NVhr2gaFrOQAMHQEdinkK8qupL6XQC2IzlSD7KpLdnWcOwf_40Ax6b2LhsYRJ8p2dalEJ2ulqjpL66PUBB9joEFny3sMvzQIvYDXO30Crxfw-gg-9306rTj0e7L_ul5JZ8H1UUDZ6LOjoKNxNBmyLpBJ2nr3nxV_AZ91mRM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2609456635</pqid></control><display><type>article</type><title>Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing</title><source>Elsevier ScienceDirect Journals</source><creator>Wang, Xiaoyu ; Dang, Qifeng ; Liu, Chengsheng ; Chang, Guozhu ; Song, Hao ; Xu, Qing ; Ma, Yue ; Li, Boyuan ; Zhang, Bonian ; Cha, Dongsu</creator><creatorcontrib>Wang, Xiaoyu ; Dang, Qifeng ; Liu, Chengsheng ; Chang, Guozhu ; Song, Hao ; Xu, Qing ; Ma, Yue ; Li, Boyuan ; Zhang, Bonian ; Cha, Dongsu</creatorcontrib><description>This work aims to fabricate multifunctional hemostatic sponges (C-ODs). Porous C-ODs were first constructed by using capric acid-modified chitosan (CSCA) and oxidized dextrans (ODs) with different oxidation degrees. Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100–200 μm in pore size) were synthesized, evidenced by FT-IR, 1H NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2's dynamic blood clotting was within 30 s. In three animal injury models, C-OD2's hemostasis time and blood loss were fairly lower than commercial gelatin sponge. Totally, C-OD2 might serve as an ideal hemostatic dressing.
[Display omitted]</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2021.118782</identifier><identifier>PMID: 34893218</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antibacterial activity ; Capric acid ; Chitosan ; Hemostatic sponge ; Oxidized dextran</subject><ispartof>Carbohydrate polymers, 2022-02, Vol.277, p.118782-118782, Article 118782</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-daa6cb7267889316c751ddc87a0434f11f9e1d316c11fa492ebb41e8109c3f493</citedby><cites>FETCH-LOGICAL-c365t-daa6cb7267889316c751ddc87a0434f11f9e1d316c11fa492ebb41e8109c3f493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2021.118782$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34893218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaoyu</creatorcontrib><creatorcontrib>Dang, Qifeng</creatorcontrib><creatorcontrib>Liu, Chengsheng</creatorcontrib><creatorcontrib>Chang, Guozhu</creatorcontrib><creatorcontrib>Song, Hao</creatorcontrib><creatorcontrib>Xu, Qing</creatorcontrib><creatorcontrib>Ma, Yue</creatorcontrib><creatorcontrib>Li, Boyuan</creatorcontrib><creatorcontrib>Zhang, Bonian</creatorcontrib><creatorcontrib>Cha, Dongsu</creatorcontrib><title>Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>This work aims to fabricate multifunctional hemostatic sponges (C-ODs). Porous C-ODs were first constructed by using capric acid-modified chitosan (CSCA) and oxidized dextrans (ODs) with different oxidation degrees. Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100–200 μm in pore size) were synthesized, evidenced by FT-IR, 1H NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2's dynamic blood clotting was within 30 s. In three animal injury models, C-OD2's hemostasis time and blood loss were fairly lower than commercial gelatin sponge. Totally, C-OD2 might serve as an ideal hemostatic dressing.
[Display omitted]</description><subject>Antibacterial activity</subject><subject>Capric acid</subject><subject>Chitosan</subject><subject>Hemostatic sponge</subject><subject>Oxidized dextran</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkMFu1DAQhi1URLeFRwD52EsWT-I4yamqqtJWqsQFztbEnux6lY2D7S0F8fA42i1XfBl75p8Z_x9jH0GsQYD6vFsbDP3sx3UpSlgDtE1bvmGrHLsCKinP2EqAlEWroDlnFzHuRD4KxDt2Xsm2q0poV-zPzZRcjyZRcDjy2Qd_iDzOftoQH7APzmAiy3-6tOUG5_zmaJwtNgGHpWC2LvmIE8fJcv_irPuds5ZeUliSkSOf_DONfEt7HxOmPMAGitFNm_fs7YBjpA-neMm-f7n7dvtQPH29f7y9eSpMpepUWERl-qZUTZu_Dco0NVhr2gaFrOQAMHQEdinkK8qupL6XQC2IzlSD7KpLdnWcOwf_40Ax6b2LhsYRJ8p2dalEJ2ulqjpL66PUBB9joEFny3sMvzQIvYDXO30Crxfw-gg-9306rTj0e7L_ul5JZ8H1UUDZ6LOjoKNxNBmyLpBJ2nr3nxV_AZ91mRM</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Wang, Xiaoyu</creator><creator>Dang, Qifeng</creator><creator>Liu, Chengsheng</creator><creator>Chang, Guozhu</creator><creator>Song, Hao</creator><creator>Xu, Qing</creator><creator>Ma, Yue</creator><creator>Li, Boyuan</creator><creator>Zhang, Bonian</creator><creator>Cha, Dongsu</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing</title><author>Wang, Xiaoyu ; Dang, Qifeng ; Liu, Chengsheng ; Chang, Guozhu ; Song, Hao ; Xu, Qing ; Ma, Yue ; Li, Boyuan ; Zhang, Bonian ; Cha, Dongsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-daa6cb7267889316c751ddc87a0434f11f9e1d316c11fa492ebb41e8109c3f493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibacterial activity</topic><topic>Capric acid</topic><topic>Chitosan</topic><topic>Hemostatic sponge</topic><topic>Oxidized dextran</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiaoyu</creatorcontrib><creatorcontrib>Dang, Qifeng</creatorcontrib><creatorcontrib>Liu, Chengsheng</creatorcontrib><creatorcontrib>Chang, Guozhu</creatorcontrib><creatorcontrib>Song, Hao</creatorcontrib><creatorcontrib>Xu, Qing</creatorcontrib><creatorcontrib>Ma, Yue</creatorcontrib><creatorcontrib>Li, Boyuan</creatorcontrib><creatorcontrib>Zhang, Bonian</creatorcontrib><creatorcontrib>Cha, Dongsu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaoyu</au><au>Dang, Qifeng</au><au>Liu, Chengsheng</au><au>Chang, Guozhu</au><au>Song, Hao</au><au>Xu, Qing</au><au>Ma, Yue</au><au>Li, Boyuan</au><au>Zhang, Bonian</au><au>Cha, Dongsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>277</volume><spage>118782</spage><epage>118782</epage><pages>118782-118782</pages><artnum>118782</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>This work aims to fabricate multifunctional hemostatic sponges (C-ODs). Porous C-ODs were first constructed by using capric acid-modified chitosan (CSCA) and oxidized dextrans (ODs) with different oxidation degrees. Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100–200 μm in pore size) were synthesized, evidenced by FT-IR, 1H NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2's dynamic blood clotting was within 30 s. In three animal injury models, C-OD2's hemostasis time and blood loss were fairly lower than commercial gelatin sponge. Totally, C-OD2 might serve as an ideal hemostatic dressing.
[Display omitted]</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34893218</pmid><doi>10.1016/j.carbpol.2021.118782</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0144-8617 |
| ispartof | Carbohydrate polymers, 2022-02, Vol.277, p.118782-118782, Article 118782 |
| issn | 0144-8617 1879-1344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2609456635 |
| source | Elsevier ScienceDirect Journals |
| subjects | Antibacterial activity Capric acid Chitosan Hemostatic sponge Oxidized dextran |
| title | Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T03%3A31%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibacterial%20porous%20sponge%20fabricated%20with%20capric%20acid-grafted%20chitosan%20and%20oxidized%20dextran%20as%20a%20novel%20hemostatic%20dressing&rft.jtitle=Carbohydrate%20polymers&rft.au=Wang,%20Xiaoyu&rft.date=2022-02-01&rft.volume=277&rft.spage=118782&rft.epage=118782&rft.pages=118782-118782&rft.artnum=118782&rft.issn=0144-8617&rft.eissn=1879-1344&rft_id=info:doi/10.1016/j.carbpol.2021.118782&rft_dat=%3Cproquest_cross%3E2609456635%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2609456635&rft_id=info:pmid/34893218&rft_els_id=S0144861721011693&rfr_iscdi=true |