Multiplexed Screening of Thousands of Natural Products for Protein–Ligand Binding in Native Mass Spectrometry

The structural diversity of natural products offers unique opportunities for drug discovery, but challenges associated with their isolation and screening can hinder the identification of drug-like molecules from complex natural product extracts. Here we introduce a mass spectrometry-based approach t...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-12, Vol.143 (50), p.21379-21387
Hauptverfasser:	Nguyen, Giang T. H, Bennett, Jack L, Liu, Sherrie, Hancock, Sarah E, Winter, Daniel L, Glover, Dominic J, Donald, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemistry Biological Products - metabolism Carbonic Anhydrase I - chemistry Carbonic Anhydrase I - metabolism Chromatography, High Pressure Liquid Humans Ligands Metabolomics - methods Proteins - chemistry Proteins - metabolism Tandem Mass Spectrometry
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