BNIP3 contributes to silibinin-induced DNA double strand breaks in glioma cells via inhibition of mTOR

BNIP3 is found to eliminate cancer cells via causing mitochondrial damage and endoplasmic reticulum stress, but it remains elusive of its role in regulating DNA double strand breaks (DSBs). In this study, we find that silibinin triggers DNA DSBs, ROS accumulation and expressional upregulation of BNI...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-01, Vol.589, p.1-8
Hauptverfasser:	Hua, Cong, Wang, Xuanzhong, Liang, Shipeng, chen, Xi, Li, Chen, You, Guangqiang, Wang, Chongcheng, Luo, Tianfei, Wang, Zhenchuan, Ge, Pengfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y+ - metabolism BNIP3 Catalase - metabolism Cell Line, Tumor Cysteine - metabolism DNA Breaks, Double-Stranded - drug effects DNA double Strand breaks Down-Regulation - drug effects Glioma - metabolism Glioma - pathology Glutathione - metabolism Humans Membrane Proteins - metabolism mTOR Proto-Oncogene Proteins - metabolism Reactive Oxygen Species - metabolism ROS Silibinin Silybin - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
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