Impaired cooperation between IFT74/BBS22-IFT81 and IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome

The IFT-B complex mediates ciliary anterograde protein trafficking and membrane protein export together with the BBSome. Bardet-Biedl syndrome (BBS) is caused by mutations in not only all BBSome subunits but also in some IFT-B subunits, including IFT74/BBS22 and IFT27/BBS19, which form heterodimers...

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Veröffentlicht in:	Human molecular genetics 2022-05, Vol.31 (10), p.1681-1693
Hauptverfasser:	Zhou, Zhuang, Qiu, Hantian, Castro-Araya, Roiner-Francisco, Takei, Ryota, Nakayama, Kazuhisa, Katoh, Yohei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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