Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

Human sodium–glucose cotransporter 2 (hSGLT2) mediates the reabsorption of the majority of filtrated glucose in the kidney 1 . Pharmacological inhibition of hSGLT2 by oral small-molecule inhibitors, such as empagliflozin, leads to enhanced excretion of glucose and is widely used in the clinic to man...

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Veröffentlicht in:	Nature (London) 2022-01, Vol.601 (7892), p.280-284
Hauptverfasser:	Niu, Yange, Liu, Rui, Guan, Chengcheng, Zhang, Yuan, Chen, Zhixing, Hoerer, Stefan, Nar, Herbert, Chen, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/154/436/2387 631/443/272 631/443/319/1642/137/773 631/535/1258/1259 692/699/317 82/80 Binding sites Conformation Cryoelectron Microscopy Design optimization Electron microscopy Glucose Glucose - metabolism Glucose transporter Humanities and Social Sciences Humans Inhibitors Microscopy Molecular weight multidisciplinary Mutation Proteins Reabsorption Science Science (multidisciplinary) Sodium Sodium-glucose cotransporter Sodium-Glucose Transporter 2 - chemistry Sodium-Glucose Transporter 2 - metabolism Sodium-Glucose Transporter 2 - ultrastructure Sodium-Glucose Transporter 2 Inhibitors - chemistry Sodium-Glucose Transporter 2 Inhibitors - pharmacology Substrates Vestibules
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