Non-genetic determinants of malignant clonal fitness at single-cell resolution

All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles imparted by genetic intratumour heterogeneity are becoming increasingly clear 1 , little is known about the non-genetic mechanisms that contribute to intratumour heterogeneity...

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Veröffentlicht in:	Nature (London) 2022-01, Vol.601 (7891), p.125-131
Hauptverfasser:	Fennell, Katie A., Vassiliadis, Dane, Lam, Enid Y. N., Martelotto, Luciano G., Balic, Jesse J., Hollizeck, Sebastian, Weber, Tom S., Semple, Timothy, Wang, Qing, Miles, Denise C., MacPherson, Laura, Chan, Yih-Chih, Guirguis, Andrew A., Kats, Lev M., Wong, Emily S., Dawson, Sarah-Jane, Naik, Shalin H., Dawson, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/31 38/22 38/35 38/39 38/77 45/23 45/29 631/337/2019 631/67/1990/283 631/67/2329 631/67/71 64/60 Acute myeloid leukemia Animal models Animals Antigen presentation Antigens Cancer Cell Competition - drug effects Cell Line Cell Lineage - drug effects Chemotherapy Clonal selection Clone Cells - drug effects Clone Cells - metabolism Clone Cells - pathology Cloning Competition Female Fitness Gene expression Genotype & phenotype Hematopoietic stem cells Heterogeneity Humanities and Social Sciences Humans Influence Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukocytes Mice Mice, Inbred C57BL Microenvironments Minimal residual disease multidisciplinary Mutation Peptidase Peptidases Reproductive fitness Science Science (multidisciplinary) Secretory Leukocyte Peptidase Inhibitor - metabolism Single-Cell Analysis Stem cell transplantation Stem cells Transcription Transplants & implants Tumors
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