Decatungstate Catalyzed Synthesis of Trifluoromethylthioesters from Aldehydes via a Radical Process
Here we report a mild and general method for the trifluoromethylthiolation of aldehydes using N-trifluoromethylthiosaccharin as the CF3S radical source and sodium decatungstate (NaDT) as the photocatalyst. This reaction proceeds via hydrogen atom abstraction by photoactivated DT and features good fu...
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| Veröffentlicht in: | Journal of organic chemistry 2022-01, Vol.87 (1), p.765-775 |
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| container_end_page | 775 |
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| container_issue | 1 |
| container_start_page | 765 |
| container_title | Journal of organic chemistry |
| container_volume | 87 |
| creator | Ye, Zhegao Lei, Ziran Ye, Xiaodong Zhou, Liejin Wang, Yanan Yuan, Zheliang Gao, Feng Britton, Robert |
| description | Here we report a mild and general method for the trifluoromethylthiolation of aldehydes using N-trifluoromethylthiosaccharin as the CF3S radical source and sodium decatungstate (NaDT) as the photocatalyst. This reaction proceeds via hydrogen atom abstraction by photoactivated DT and features good functional groups and substrate tolerance. Generally, electron-rich aldehydes demonstrate better reactivity than electron-deficient ones and good selectivity is observed for the trifluoromethylthiolation of aldehydic C–H bonds over tertiary and benzylic C–H bonds. Preliminary mechanistic studies have shown that a free radical process is involved. |
| doi_str_mv | 10.1021/acs.joc.1c02244 |
| format | Article |
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Org. Chem</addtitle><date>2022-01-07</date><risdate>2022</risdate><volume>87</volume><issue>1</issue><spage>765</spage><epage>775</epage><pages>765-775</pages><issn>0022-3263</issn><eissn>1520-6904</eissn><abstract>Here we report a mild and general method for the trifluoromethylthiolation of aldehydes using N-trifluoromethylthiosaccharin as the CF3S radical source and sodium decatungstate (NaDT) as the photocatalyst. This reaction proceeds via hydrogen atom abstraction by photoactivated DT and features good functional groups and substrate tolerance. Generally, electron-rich aldehydes demonstrate better reactivity than electron-deficient ones and good selectivity is observed for the trifluoromethylthiolation of aldehydic C–H bonds over tertiary and benzylic C–H bonds. 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| ispartof | Journal of organic chemistry, 2022-01, Vol.87 (1), p.765-775 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Aldehydes Catalysis Hydrogen |
| title | Decatungstate Catalyzed Synthesis of Trifluoromethylthioesters from Aldehydes via a Radical Process |
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