Amelioration of acute myocardial infarction injury through targeted ferritin nanocages loaded with an ALKBH5 inhibitor

The roles of m6A RNA methylation and mitochondrial metabolism in acute myocardial infarction (AMI) remain unclear. In this study, we demonstrated that m6A RNA methylation affected ischemia/reperfusion (I/R) injury in AMI through the “Erasers” protein ALKBH5-related metabolic reprogramming, character...

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Veröffentlicht in:	Acta biomaterialia 2022-03, Vol.140, p.481-491
Hauptverfasser:	Cheng, Panke, Han, Hukui, Chen, Fuli, Cheng, Lianying, Ma, Cui, Huang, Hui, Chen, Chi, Li, Hua, Cai, Hao, Huang, Hao, Li, Gang, Tao, Jianhong
Format:	Artikel
Sprache:	eng
Schlagworte:	AlkB Homolog 5, RNA Demethylase - metabolism ALKBH5 Archaeoglobus fulgidus Bioengineering Cardiac function Dismantling Enzymatic activity Ferritin Ferritins Genetic engineering Heart Heart attacks Humans Injuries Ischemia Lysine Magnesium Metabolism Methylation Mitochondria Myocardial infarction Myocardial Infarction - metabolism N6-methyladenosine Proteins Recombination Reperfusion Residues Ribonucleic acid RNA Tricarboxylic acid cycle
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