Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum

Cholinergic transmission underlies higher brain functions such as cognition and movement. To elucidate the process whereby acetylcholine (ACh) release is maintained and regulated in the central nervous system, uptake of [3H]choline and subsequent synthesis and release of [3H]ACh were investigated in...

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Veröffentlicht in:	Journal of neurochemistry 2022-02, Vol.160 (3), p.342-355
Hauptverfasser:	Muramatsu, Ikunobu, Uwada, Junsuke, Chihara, Kazuyasu, Sada, Kiyonao, Wang, Mao‐Hsien, Yazawa, Takashi, Taniguchi, Takanobu, Ishibashi, Takaharu, Masuoka, Takayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acetylcholine Acetylcholine - biosynthesis acetylcholine esterase Acetylcholine receptors (muscarinic) Acetylcholinesterase Acetylcholinesterase - metabolism Animals Calcium Channel Blockers - pharmacology Calcium ions Central nervous system Choline Choline - metabolism cholinergic release Cholinergic transmission Cholinergics Cholinesterase Inhibitors - pharmacology Cognition Cytosol Depolarization Dopamine D2 receptors Electric Stimulation Electrical stimuli Esterase Male Neostriatum Neostriatum - metabolism Potassium chloride Potassium Chloride - pharmacology presynaptic modulation Radiopharmaceuticals Rats Rats, Wistar Receptor, Muscarinic M2 - drug effects Receptor, Muscarinic M2 - metabolism Receptors, Dopamine D1 - drug effects Receptors, Dopamine D1 - metabolism Stimulation striatum Synaptic cleft Synthesis Tetrodotoxin Toxins Vesamicol Vesicular Acetylcholine Transport Proteins - antagonists & inhibitors Vesicular Acetylcholine Transport Proteins - metabolism
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