SARS-CoV-2 Infection Among People Living With HIV Compared With People Without HIV: Survey Results From the MACS-WIHS Combined Cohort Study
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) symptoms among people living with HIV (PLWH) are not well described. Longitudinal survey within the MACS/WIHS Combined Cohort Study (MWCCS) of PLWH compared with similar HIV-seronegative (S...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2022-01, Vol.89 (1), p.1-8 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | D'Souza, Gypsyamber Tong, Weiqun Gustafson, Deborah Alcaide, Maria L. Lahiri, Cecile D. Sharma, Anjali French, Audrey L. Palella, Frank J. Kempf, Mirjam-Colette Mimiaga, Matthew J. Ramirez, Catalina Kassaye, Seble Rinaldo, Charles R. Brown, Todd T. Tien, Phyllis C. Adimora, Adaora A. |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) symptoms among people living with HIV (PLWH) are not well described.
Longitudinal survey within the MACS/WIHS Combined Cohort Study (MWCCS) of PLWH compared with similar HIV-seronegative (SN) individuals.
Telephone-administered survey of MWCCS participants at 13 clinical research sites across the United States addressing COVID-19 symptoms, SARS-CoV-2 testing, and pandemic impact on social distancing and antiretroviral therapy (ART) use. Primary data collection occurred during May (wave 1), June-July (wave 2), and August-September, 2020 (wave 3).
One-third of MWCCS participants were tested for SARS-CoV-2 infection; 10% was tested ≥2 times. Similar proportions of PLWH and SN participants were tested, but SARS-CoV-2 positivity was higher among PLWH than among SN individuals (9.4% vs 4.8%, P = 0.003). Odds of SARS-CoV-2 positivity remained higher among PLWH after adjusting for age, sex, race/ethnicity, and study site (adjusted odds ratio = 2.0, 95% confidence interval = 1.2 to 3.2). SARS-CoV-2 positivity was not associated with CD4 cell counts among PLWH. Among SARS-CoV-2 positive participants, 9% had no symptoms, 7% had 1-2 mild symptoms, and 84% had ≥3 symptoms. Most of the (98%) participants reported physical distancing during all survey waves; self-reported ART adherence among PLWH was not adversely affected during the pandemic compared with the previous year (similar adherence in 89% of participants, improved in 9% of participants, and decreased in 2% of participants).
Despite similar SARS-CoV-2 testing and physical distancing profiles by HIV serostatus among MWCCS participants, PLWH who reported SARS-CoV-2 testing were more likely to have a positive test result. Additional studies are needed to determine whether and why PLWH are at increased risk of SARS-CoV-2 infection. |
| doi_str_mv | 10.1097/QAI.0000000000002822 |
| format | Article |
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Longitudinal survey within the MACS/WIHS Combined Cohort Study (MWCCS) of PLWH compared with similar HIV-seronegative (SN) individuals.
Telephone-administered survey of MWCCS participants at 13 clinical research sites across the United States addressing COVID-19 symptoms, SARS-CoV-2 testing, and pandemic impact on social distancing and antiretroviral therapy (ART) use. Primary data collection occurred during May (wave 1), June-July (wave 2), and August-September, 2020 (wave 3).
One-third of MWCCS participants were tested for SARS-CoV-2 infection; 10% was tested ≥2 times. Similar proportions of PLWH and SN participants were tested, but SARS-CoV-2 positivity was higher among PLWH than among SN individuals (9.4% vs 4.8%, P = 0.003). Odds of SARS-CoV-2 positivity remained higher among PLWH after adjusting for age, sex, race/ethnicity, and study site (adjusted odds ratio = 2.0, 95% confidence interval = 1.2 to 3.2). SARS-CoV-2 positivity was not associated with CD4 cell counts among PLWH. Among SARS-CoV-2 positive participants, 9% had no symptoms, 7% had 1-2 mild symptoms, and 84% had ≥3 symptoms. Most of the (98%) participants reported physical distancing during all survey waves; self-reported ART adherence among PLWH was not adversely affected during the pandemic compared with the previous year (similar adherence in 89% of participants, improved in 9% of participants, and decreased in 2% of participants).
Despite similar SARS-CoV-2 testing and physical distancing profiles by HIV serostatus among MWCCS participants, PLWH who reported SARS-CoV-2 testing were more likely to have a positive test result. Additional studies are needed to determine whether and why PLWH are at increased risk of SARS-CoV-2 infection.</description><identifier>ISSN: 1525-4135</identifier><identifier>ISSN: 1944-7884</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0000000000002822</identifier><identifier>PMID: 34878431</identifier><language>eng</language><publisher>United States: JAIDS Journal of Acquired Immune Deficiency Syndromes</publisher><subject>Aged ; Antiretroviral agents ; Antiretroviral therapy ; CD4 antigen ; CD4 Lymphocyte Count ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Coronaviruses ; Cough ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 Testing ; Data collection ; Disease control ; Ethnicity ; Female ; Fever - etiology ; Health risks ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Infections ; Longitudinal Studies ; Male ; Middle Aged ; Minority & ethnic groups ; Pandemics ; Pharyngitis - etiology ; Polls & surveys ; Prevalence ; Public health ; Respiratory diseases ; SARS-CoV-2 - isolation & purification ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Sexually transmitted diseases ; Signs and symptoms ; STD ; Viral diseases</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2022-01, Vol.89 (1), p.1-8</ispartof><rights>JAIDS Journal of Acquired Immune Deficiency Syndromes</rights><rights>Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4261-89850ed1905668b85db884ea25ea23f4ca35e4d1445059d3047deee35347b08d3</citedby><cites>FETCH-LOGICAL-c4261-89850ed1905668b85db884ea25ea23f4ca35e4d1445059d3047deee35347b08d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00126334-202201010-00001$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34878431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Souza, Gypsyamber</creatorcontrib><creatorcontrib>Tong, Weiqun</creatorcontrib><creatorcontrib>Gustafson, Deborah</creatorcontrib><creatorcontrib>Alcaide, Maria L.</creatorcontrib><creatorcontrib>Lahiri, Cecile D.</creatorcontrib><creatorcontrib>Sharma, Anjali</creatorcontrib><creatorcontrib>French, Audrey L.</creatorcontrib><creatorcontrib>Palella, Frank J.</creatorcontrib><creatorcontrib>Kempf, Mirjam-Colette</creatorcontrib><creatorcontrib>Mimiaga, Matthew J.</creatorcontrib><creatorcontrib>Ramirez, Catalina</creatorcontrib><creatorcontrib>Kassaye, Seble</creatorcontrib><creatorcontrib>Rinaldo, Charles R.</creatorcontrib><creatorcontrib>Brown, Todd T.</creatorcontrib><creatorcontrib>Tien, Phyllis C.</creatorcontrib><creatorcontrib>Adimora, Adaora A.</creatorcontrib><title>SARS-CoV-2 Infection Among People Living With HIV Compared With People Without HIV: Survey Results From the MACS-WIHS Combined Cohort Study</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) symptoms among people living with HIV (PLWH) are not well described.
Longitudinal survey within the MACS/WIHS Combined Cohort Study (MWCCS) of PLWH compared with similar HIV-seronegative (SN) individuals.
Telephone-administered survey of MWCCS participants at 13 clinical research sites across the United States addressing COVID-19 symptoms, SARS-CoV-2 testing, and pandemic impact on social distancing and antiretroviral therapy (ART) use. Primary data collection occurred during May (wave 1), June-July (wave 2), and August-September, 2020 (wave 3).
One-third of MWCCS participants were tested for SARS-CoV-2 infection; 10% was tested ≥2 times. Similar proportions of PLWH and SN participants were tested, but SARS-CoV-2 positivity was higher among PLWH than among SN individuals (9.4% vs 4.8%, P = 0.003). Odds of SARS-CoV-2 positivity remained higher among PLWH after adjusting for age, sex, race/ethnicity, and study site (adjusted odds ratio = 2.0, 95% confidence interval = 1.2 to 3.2). SARS-CoV-2 positivity was not associated with CD4 cell counts among PLWH. Among SARS-CoV-2 positive participants, 9% had no symptoms, 7% had 1-2 mild symptoms, and 84% had ≥3 symptoms. Most of the (98%) participants reported physical distancing during all survey waves; self-reported ART adherence among PLWH was not adversely affected during the pandemic compared with the previous year (similar adherence in 89% of participants, improved in 9% of participants, and decreased in 2% of participants).
Despite similar SARS-CoV-2 testing and physical distancing profiles by HIV serostatus among MWCCS participants, PLWH who reported SARS-CoV-2 testing were more likely to have a positive test result. Additional studies are needed to determine whether and why PLWH are at increased risk of SARS-CoV-2 infection.</description><subject>Aged</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral therapy</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Coronaviruses</subject><subject>Cough</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Testing</subject><subject>Data collection</subject><subject>Disease control</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Fever - etiology</subject><subject>Health risks</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Pandemics</subject><subject>Pharyngitis - etiology</subject><subject>Polls & surveys</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Respiratory diseases</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sexually transmitted diseases</subject><subject>Signs and symptoms</subject><subject>STD</subject><subject>Viral diseases</subject><issn>1525-4135</issn><issn>1944-7884</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtu1DAQQC1ERUvhDxCyxAsvbn1NHN6iiLKRtio00D5GucySlCRebKfVfgM_XUe7QFVblsfWmaOxB6F3jJ4xmsTn39L8jD4ZXHP-Ap2wREoSay1fhlhxRSQT6hi9du6OUhZJmbxCx0LqWEvBTtCfIr0uSGZuCMf5tIHG92bC6Wimn_grmO0AeN3f9-F02_sOr_IbnJlxW1lo9zcHaInN7BfgEy5mew87fA1uHrzDF9aM2HeAL9OsILf5qlgcdT8FR2Y6Yz0u_Nzu3qCjTTU4eHvYT9GPi8_fsxVZX33Js3RNGskjRnSiFYWWJVRFka61auvwXKi4CktsZFMJBbJlUiqqklZQGbcAIJSQcU11K07Rx713a83vGZwvx941MAzVBGZ2JY-oXr44EgH98Ay9M7OdQnULFUdchq8OlNxTjTXOWdiUW9uPld2VjJaLqQzNKp83K6S9P8jneoT2X9Lf7vz3PpjBg3W_hvkBbNlBNfgu-BgPJUrCKeeUhUkWNROPM6ObiA</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>D'Souza, Gypsyamber</creator><creator>Tong, Weiqun</creator><creator>Gustafson, Deborah</creator><creator>Alcaide, Maria L.</creator><creator>Lahiri, Cecile D.</creator><creator>Sharma, Anjali</creator><creator>French, Audrey L.</creator><creator>Palella, Frank J.</creator><creator>Kempf, Mirjam-Colette</creator><creator>Mimiaga, Matthew J.</creator><creator>Ramirez, Catalina</creator><creator>Kassaye, Seble</creator><creator>Rinaldo, Charles R.</creator><creator>Brown, Todd T.</creator><creator>Tien, Phyllis C.</creator><creator>Adimora, Adaora A.</creator><general>JAIDS Journal of Acquired Immune Deficiency Syndromes</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220101</creationdate><title>SARS-CoV-2 Infection Among People Living With HIV Compared With People Without HIV: Survey Results From the MACS-WIHS Combined Cohort Study</title><author>D'Souza, Gypsyamber ; Tong, Weiqun ; Gustafson, Deborah ; Alcaide, Maria L. ; Lahiri, Cecile D. ; Sharma, Anjali ; French, Audrey L. ; Palella, Frank J. ; Kempf, Mirjam-Colette ; Mimiaga, Matthew J. ; Ramirez, Catalina ; Kassaye, Seble ; Rinaldo, Charles R. ; Brown, Todd T. ; Tien, Phyllis C. ; Adimora, Adaora A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4261-89850ed1905668b85db884ea25ea23f4ca35e4d1445059d3047deee35347b08d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral therapy</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Coronaviruses</topic><topic>Cough</topic><topic>COVID-19</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Testing</topic><topic>Data collection</topic><topic>Disease control</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Fever - etiology</topic><topic>Health risks</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Pandemics</topic><topic>Pharyngitis - etiology</topic><topic>Polls & surveys</topic><topic>Prevalence</topic><topic>Public health</topic><topic>Respiratory diseases</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Sexually transmitted diseases</topic><topic>Signs and symptoms</topic><topic>STD</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'Souza, Gypsyamber</creatorcontrib><creatorcontrib>Tong, Weiqun</creatorcontrib><creatorcontrib>Gustafson, Deborah</creatorcontrib><creatorcontrib>Alcaide, Maria L.</creatorcontrib><creatorcontrib>Lahiri, Cecile D.</creatorcontrib><creatorcontrib>Sharma, Anjali</creatorcontrib><creatorcontrib>French, Audrey L.</creatorcontrib><creatorcontrib>Palella, Frank J.</creatorcontrib><creatorcontrib>Kempf, Mirjam-Colette</creatorcontrib><creatorcontrib>Mimiaga, Matthew J.</creatorcontrib><creatorcontrib>Ramirez, Catalina</creatorcontrib><creatorcontrib>Kassaye, Seble</creatorcontrib><creatorcontrib>Rinaldo, Charles R.</creatorcontrib><creatorcontrib>Brown, Todd T.</creatorcontrib><creatorcontrib>Tien, Phyllis C.</creatorcontrib><creatorcontrib>Adimora, Adaora A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'Souza, Gypsyamber</au><au>Tong, Weiqun</au><au>Gustafson, Deborah</au><au>Alcaide, Maria L.</au><au>Lahiri, Cecile D.</au><au>Sharma, Anjali</au><au>French, Audrey L.</au><au>Palella, Frank J.</au><au>Kempf, Mirjam-Colette</au><au>Mimiaga, Matthew J.</au><au>Ramirez, Catalina</au><au>Kassaye, Seble</au><au>Rinaldo, Charles R.</au><au>Brown, Todd T.</au><au>Tien, Phyllis C.</au><au>Adimora, Adaora A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 Infection Among People Living With HIV Compared With People Without HIV: Survey Results From the MACS-WIHS Combined Cohort Study</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>89</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1525-4135</issn><issn>1944-7884</issn><eissn>1944-7884</eissn><abstract>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) symptoms among people living with HIV (PLWH) are not well described.
Longitudinal survey within the MACS/WIHS Combined Cohort Study (MWCCS) of PLWH compared with similar HIV-seronegative (SN) individuals.
Telephone-administered survey of MWCCS participants at 13 clinical research sites across the United States addressing COVID-19 symptoms, SARS-CoV-2 testing, and pandemic impact on social distancing and antiretroviral therapy (ART) use. Primary data collection occurred during May (wave 1), June-July (wave 2), and August-September, 2020 (wave 3).
One-third of MWCCS participants were tested for SARS-CoV-2 infection; 10% was tested ≥2 times. Similar proportions of PLWH and SN participants were tested, but SARS-CoV-2 positivity was higher among PLWH than among SN individuals (9.4% vs 4.8%, P = 0.003). Odds of SARS-CoV-2 positivity remained higher among PLWH after adjusting for age, sex, race/ethnicity, and study site (adjusted odds ratio = 2.0, 95% confidence interval = 1.2 to 3.2). SARS-CoV-2 positivity was not associated with CD4 cell counts among PLWH. Among SARS-CoV-2 positive participants, 9% had no symptoms, 7% had 1-2 mild symptoms, and 84% had ≥3 symptoms. Most of the (98%) participants reported physical distancing during all survey waves; self-reported ART adherence among PLWH was not adversely affected during the pandemic compared with the previous year (similar adherence in 89% of participants, improved in 9% of participants, and decreased in 2% of participants).
Despite similar SARS-CoV-2 testing and physical distancing profiles by HIV serostatus among MWCCS participants, PLWH who reported SARS-CoV-2 testing were more likely to have a positive test result. Additional studies are needed to determine whether and why PLWH are at increased risk of SARS-CoV-2 infection.</abstract><cop>United States</cop><pub>JAIDS Journal of Acquired Immune Deficiency Syndromes</pub><pmid>34878431</pmid><doi>10.1097/QAI.0000000000002822</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 2022-01, Vol.89 (1), p.1-8 |
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| source | Freely Accessible Journals; MEDLINE; Journals@Ovid LWW Legacy Archive |
| subjects | Aged Antiretroviral agents Antiretroviral therapy CD4 antigen CD4 Lymphocyte Count Cohort analysis Cohort Studies Confidence intervals Coronaviruses Cough COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 Testing Data collection Disease control Ethnicity Female Fever - etiology Health risks HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Humans Infections Longitudinal Studies Male Middle Aged Minority & ethnic groups Pandemics Pharyngitis - etiology Polls & surveys Prevalence Public health Respiratory diseases SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sexually transmitted diseases Signs and symptoms STD Viral diseases |
| title | SARS-CoV-2 Infection Among People Living With HIV Compared With People Without HIV: Survey Results From the MACS-WIHS Combined Cohort Study |
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