Methylation quantitative locus rs3758653 in the DRD4 gene is associated with duration from first heroin exposure to addiction

[Display omitted] •We found several correlations of SNPs-CpG methylations (mQTLs) in the DRD4 gene.•Unique SNP-CpG methylation correlations were found in the heroin addiction group.•SNP (mQTL) rs3758653 was related with duration from first heroin use to addiction.•Rs3758653 was related with DRD4 gen...

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Veröffentlicht in:	Brain research 2022-01, Vol.1775, p.147746-147746, Article 147746
Hauptverfasser:	Zhang, Rui, Dang, Wei, Zhang, Jianbo, He, Ruifeng, Li, Guibin, Zhang, Luying, Wang, Zhikang, Zong, Hua, Liu, Ning, Jia, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult CpG Islands DNA Methylation Epigenesis, Genetic Female Genotype Heroin Dependence - genetics Humans Male Methylation quantitative locus Opioid addiction Polymorphism, Single Nucleotide Quantitative Trait Loci Receptors, Dopamine D4 - genetics
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