Linezolid-Associated Posterior Reversible Leuco-encephalopathy Syndrome in a Patient with Disseminated Tuberculosis

Neurological side-effects of linezolid manifesting as a posterior reversible leuco-encephalopathy syndrome (PRES) is rare. Early identification of this offending drug might reverse this catastrophic event. We report a 45-year-old female, who was diagnosed as a case of disseminated tuberculosis and w...

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Veröffentlicht in:	Tropical doctor 2022-01, Vol.52 (1), p.196-198
Hauptverfasser:	Tomar, Laxmikant Ramkumarsingh, Pandita, Neha, Arya, Sakshi, Agrawal, CS
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - diagnostic imaging Female Humans Linezolid - adverse effects Magnetic Resonance Imaging Middle Aged Posterior Leukoencephalopathy Syndrome - chemically induced Posterior Leukoencephalopathy Syndrome - diagnosis Posterior Leukoencephalopathy Syndrome - drug therapy Tuberculosis
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creator	Tomar, Laxmikant Ramkumarsingh Pandita, Neha Arya, Sakshi Agrawal, CS
description	Neurological side-effects of linezolid manifesting as a posterior reversible leuco-encephalopathy syndrome (PRES) is rare. Early identification of this offending drug might reverse this catastrophic event. We report a 45-year-old female, who was diagnosed as a case of disseminated tuberculosis and was treated with antitubercular drugs (ATT), but later developed ATT-induced hepatitis. She was then put on modified ATT (moxifloxacin, terizidone, and linezolid). In the next two days she developed an altered sensorium. Brain imaging was suggestive of PRES. Linezolid was withdrawn, following which she showed an excellent clinical and radiological recovery.
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subjects	Brain - diagnostic imaging Female Humans Linezolid - adverse effects Magnetic Resonance Imaging Middle Aged Posterior Leukoencephalopathy Syndrome - chemically induced Posterior Leukoencephalopathy Syndrome - diagnosis Posterior Leukoencephalopathy Syndrome - drug therapy Tuberculosis
title	Linezolid-Associated Posterior Reversible Leuco-encephalopathy Syndrome in a Patient with Disseminated Tuberculosis
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