Folic acid oversupplementation during pregnancy disorders lipid metabolism in male offspring via regulating arginase 1-associated NOS3-AMPKα pathway

Folic acid supplementation is widely accepted during pregnancy, as it exerts a protective effect on neural tube defects. However, the long-term underlying effects of folic acid supplementation during pregnancy (FASDP) on offspring remain unclear. Thirty pregnant female rats were randomly divided int...

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Veröffentlicht in:	Clinical nutrition (Edinburgh, Scotland) Scotland), 2022-01, Vol.41 (1), p.21-32
Hauptverfasser:	Liu, Zhipeng, Zhang, Yuntao, Liu, Zengjiao, Tian, Zhen, Pei, Xinyi, Liu, Liyan, Li, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Arginase Arginase - metabolism Diet - methods Dietary Supplements - adverse effects Female Folic Acid - administration & dosage Folic Acid - adverse effects Folic acid supplementation Gas Chromatography-Mass Spectrometry Gestational nutrition Hepatocytes - metabolism Lipid metabolism Lipid Metabolism - drug effects Lipid Metabolism Disorders - chemically induced Liver - metabolism Male Metabolomics Nitric Oxide Synthase Type III - metabolism Pregnancy Prenatal Exposure Delayed Effects - chemically induced Rats Signal Transduction - drug effects
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