Nano-designed CO donor ameliorates bleomycin-induced pulmonary fibrosis via macrophage manipulation

Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial pulmonary disease due to chronic inflammatory responses. The prognosis of IPF is very poor, however, the therapeutic options are very limited. Previously we developed a polymeric micellar drug delivery system of carbo...

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Veröffentlicht in:	Journal of controlled release 2022-01, Vol.341, p.566-577
Hauptverfasser:	Guo, Chunyu, Zhang, Cheng, Xia, Zhengmei, Song, Bingdong, Hu, Weirong, Cui, Yingying, Xue, Yanni, Xia, Mizhen, Xu, Dexiang, Zhang, Shichen, Fang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Bleomycin Carbon monoxide Hypoxia-inducible factor-1α Idiopathic pulmonary fibrosis Macrophage reprogramming
Online-Zugang:	Volltext
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