Long‐term effect of curcuminoid treatment on resin‐to‐dentin bond strength
Endogenous dentin proteases contribute to the degradation of collagen fibrils in the hybrid layer. Recently, inhibition of host‐derived proteases by curcuminoids has shown promising results. The aim of this study was to evaluate the effect of curcuminoid treatment on the microtensile bond strength (...
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| Veröffentlicht in: | European journal of oral sciences 2022-02, Vol.130 (1), p.e12837-n/a |
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| creator | Tekbas Atay, Meltem Seseogullari‐Dirihan, Roda Mutluay, Mustafa Murat Tezvergil‐Mutluay, Arzu |
| description | Endogenous dentin proteases contribute to the degradation of collagen fibrils in the hybrid layer. Recently, inhibition of host‐derived proteases by curcuminoids has shown promising results. The aim of this study was to evaluate the effect of curcuminoid treatment on the microtensile bond strength (μTBS) after 24 h or 12 months of storage. Fifty‐four extracted sound human molars were flattened to mid‐coronal dentin and divided into nine groups. After phosphoric acid‐etching for 15 s, the dentin was experimentally treated for 60 s using 100 μM or 200 μM of curcumin, diflourobenzocurcumin, or demethoxycurcumin dissolved in 1% and 2% dimethyl sulfoxide (DMSO)/water solutions. Untreated and DMSO‐treated groups served as controls. After bonding agent application, each tooth was restored with dental composite. The molars were sectioned into 0.9 × 0.9 × 6 mm beams. The μTBS testing was performed after 24 h and 12 months of storage in artificial saliva. Data were analyzed using regression analyses. Failure patterns were evaluated using scanning electron microscopy. Dentin treatment with curcuminoids did not adversely affect 24‐h μTBS compared to controls. After 12 months, the μTBS of curcuminoid groups was statistically significantly higher than the controls. This study indicates the feasibility of using curcuminoids as protease inhibitors. |
| doi_str_mv | 10.1111/eos.12837 |
| format | Article |
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Recently, inhibition of host‐derived proteases by curcuminoids has shown promising results. The aim of this study was to evaluate the effect of curcuminoid treatment on the microtensile bond strength (μTBS) after 24 h or 12 months of storage. Fifty‐four extracted sound human molars were flattened to mid‐coronal dentin and divided into nine groups. After phosphoric acid‐etching for 15 s, the dentin was experimentally treated for 60 s using 100 μM or 200 μM of curcumin, diflourobenzocurcumin, or demethoxycurcumin dissolved in 1% and 2% dimethyl sulfoxide (DMSO)/water solutions. Untreated and DMSO‐treated groups served as controls. After bonding agent application, each tooth was restored with dental composite. The molars were sectioned into 0.9 × 0.9 × 6 mm beams. The μTBS testing was performed after 24 h and 12 months of storage in artificial saliva. Data were analyzed using regression analyses. Failure patterns were evaluated using scanning electron microscopy. Dentin treatment with curcuminoids did not adversely affect 24‐h μTBS compared to controls. After 12 months, the μTBS of curcuminoid groups was statistically significantly higher than the controls. This study indicates the feasibility of using curcuminoids as protease inhibitors.</description><identifier>ISSN: 0909-8836</identifier><identifier>EISSN: 1600-0722</identifier><identifier>DOI: 10.1111/eos.12837</identifier><identifier>PMID: 34865272</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Bonding agents ; Bonding strength ; Collagen ; collagen matrix metalloproteinases ; Composite Resins - chemistry ; Curcumin ; cysteine cathepsins ; degradation ; Dental Bonding ; Dental materials ; Dental restorative materials ; Dentin ; Dentin - chemistry ; Dentin-Bonding Agents - chemistry ; Diarylheptanoids ; Dimethyl sulfoxide ; Etching ; Failure analysis ; Feasibility studies ; Fibrils ; Humans ; Materials Testing ; Microscopy, Electron, Scanning ; Molars ; Phosphoric acid ; Protease inhibitors ; Proteinase inhibitors ; Regression analysis ; Resin Cements - chemistry ; Saliva ; Scanning electron microscopy ; Teeth ; Tensile Strength</subject><ispartof>European journal of oral sciences, 2022-02, Vol.130 (1), p.e12837-n/a</ispartof><rights>2021 Scandinavian Division of the International Association for Dental Research. Published by John Wiley & Sons Ltd.</rights><rights>2022 Scandinavian Division of the International Association for Dental Research. 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Recently, inhibition of host‐derived proteases by curcuminoids has shown promising results. The aim of this study was to evaluate the effect of curcuminoid treatment on the microtensile bond strength (μTBS) after 24 h or 12 months of storage. Fifty‐four extracted sound human molars were flattened to mid‐coronal dentin and divided into nine groups. After phosphoric acid‐etching for 15 s, the dentin was experimentally treated for 60 s using 100 μM or 200 μM of curcumin, diflourobenzocurcumin, or demethoxycurcumin dissolved in 1% and 2% dimethyl sulfoxide (DMSO)/water solutions. Untreated and DMSO‐treated groups served as controls. After bonding agent application, each tooth was restored with dental composite. The molars were sectioned into 0.9 × 0.9 × 6 mm beams. The μTBS testing was performed after 24 h and 12 months of storage in artificial saliva. Data were analyzed using regression analyses. Failure patterns were evaluated using scanning electron microscopy. Dentin treatment with curcuminoids did not adversely affect 24‐h μTBS compared to controls. After 12 months, the μTBS of curcuminoid groups was statistically significantly higher than the controls. This study indicates the feasibility of using curcuminoids as protease inhibitors.</description><subject>Bonding agents</subject><subject>Bonding strength</subject><subject>Collagen</subject><subject>collagen matrix metalloproteinases</subject><subject>Composite Resins - chemistry</subject><subject>Curcumin</subject><subject>cysteine cathepsins</subject><subject>degradation</subject><subject>Dental Bonding</subject><subject>Dental materials</subject><subject>Dental restorative materials</subject><subject>Dentin</subject><subject>Dentin - chemistry</subject><subject>Dentin-Bonding Agents - chemistry</subject><subject>Diarylheptanoids</subject><subject>Dimethyl sulfoxide</subject><subject>Etching</subject><subject>Failure analysis</subject><subject>Feasibility studies</subject><subject>Fibrils</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molars</subject><subject>Phosphoric acid</subject><subject>Protease inhibitors</subject><subject>Proteinase inhibitors</subject><subject>Regression analysis</subject><subject>Resin Cements - chemistry</subject><subject>Saliva</subject><subject>Scanning electron microscopy</subject><subject>Teeth</subject><subject>Tensile Strength</subject><issn>0909-8836</issn><issn>1600-0722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYB_AgipvTg19ACl700O1J0jbtUcZ8gYGCei5t-mR2rMlMWmQ3P4Kf0U9iZqcHwRzy-uNP-BNySmFM_ZigcWPKUi72yJAmACEIxvbJEDLIwjTlyYAcObcEoJxm4pAMeJQmMRNsSB7mRi8-3z9atE2ASqFsA6MC2VnZNbU2dRW0Fou2Qe0fdGDR1XrrjZ8qf1nroDS6CpxnetG-HJMDVawcnuzWEXm-nj1Nb8P5_c3d9GoeSh5zEVZKyQxUklFWFghJqVSZRRCV6E-pFJT7rVSpSrCCCFRBlYQCvBRcZjHlI3LR566tee3QtXlTO4mrVaHRdC5nCQgOXHDm6fkfujSd1f53XrEkjZkvyqvLXklrnLOo8rWtm8Jucgr5tubc15x_1-zt2S6xKxusfuVPrx5MevBWr3Dzf1I-u3_sI78AXOiKRA</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Tekbas Atay, Meltem</creator><creator>Seseogullari‐Dirihan, Roda</creator><creator>Mutluay, Mustafa Murat</creator><creator>Tezvergil‐Mutluay, Arzu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1762-830X</orcidid><orcidid>https://orcid.org/0000-0003-0932-8531</orcidid><orcidid>https://orcid.org/0000-0002-1484-6774</orcidid><orcidid>https://orcid.org/0000-0003-4131-1959</orcidid></search><sort><creationdate>202202</creationdate><title>Long‐term effect of curcuminoid treatment on resin‐to‐dentin bond strength</title><author>Tekbas Atay, Meltem ; Seseogullari‐Dirihan, Roda ; Mutluay, Mustafa Murat ; Tezvergil‐Mutluay, Arzu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-dffc90f6912bae06bffb9404beae08c7134becf8f6ed040fa1fc0a0e0673c9513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bonding agents</topic><topic>Bonding strength</topic><topic>Collagen</topic><topic>collagen matrix metalloproteinases</topic><topic>Composite Resins - chemistry</topic><topic>Curcumin</topic><topic>cysteine cathepsins</topic><topic>degradation</topic><topic>Dental Bonding</topic><topic>Dental materials</topic><topic>Dental restorative materials</topic><topic>Dentin</topic><topic>Dentin - chemistry</topic><topic>Dentin-Bonding Agents - chemistry</topic><topic>Diarylheptanoids</topic><topic>Dimethyl sulfoxide</topic><topic>Etching</topic><topic>Failure analysis</topic><topic>Feasibility studies</topic><topic>Fibrils</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molars</topic><topic>Phosphoric acid</topic><topic>Protease inhibitors</topic><topic>Proteinase inhibitors</topic><topic>Regression analysis</topic><topic>Resin Cements - chemistry</topic><topic>Saliva</topic><topic>Scanning electron microscopy</topic><topic>Teeth</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tekbas Atay, Meltem</creatorcontrib><creatorcontrib>Seseogullari‐Dirihan, Roda</creatorcontrib><creatorcontrib>Mutluay, Mustafa Murat</creatorcontrib><creatorcontrib>Tezvergil‐Mutluay, Arzu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of oral sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tekbas Atay, Meltem</au><au>Seseogullari‐Dirihan, Roda</au><au>Mutluay, Mustafa Murat</au><au>Tezvergil‐Mutluay, Arzu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term effect of curcuminoid treatment on resin‐to‐dentin bond strength</atitle><jtitle>European journal of oral sciences</jtitle><addtitle>Eur J Oral Sci</addtitle><date>2022-02</date><risdate>2022</risdate><volume>130</volume><issue>1</issue><spage>e12837</spage><epage>n/a</epage><pages>e12837-n/a</pages><issn>0909-8836</issn><eissn>1600-0722</eissn><abstract>Endogenous dentin proteases contribute to the degradation of collagen fibrils in the hybrid layer. Recently, inhibition of host‐derived proteases by curcuminoids has shown promising results. The aim of this study was to evaluate the effect of curcuminoid treatment on the microtensile bond strength (μTBS) after 24 h or 12 months of storage. Fifty‐four extracted sound human molars were flattened to mid‐coronal dentin and divided into nine groups. After phosphoric acid‐etching for 15 s, the dentin was experimentally treated for 60 s using 100 μM or 200 μM of curcumin, diflourobenzocurcumin, or demethoxycurcumin dissolved in 1% and 2% dimethyl sulfoxide (DMSO)/water solutions. Untreated and DMSO‐treated groups served as controls. After bonding agent application, each tooth was restored with dental composite. The molars were sectioned into 0.9 × 0.9 × 6 mm beams. The μTBS testing was performed after 24 h and 12 months of storage in artificial saliva. Data were analyzed using regression analyses. Failure patterns were evaluated using scanning electron microscopy. Dentin treatment with curcuminoids did not adversely affect 24‐h μTBS compared to controls. After 12 months, the μTBS of curcuminoid groups was statistically significantly higher than the controls. This study indicates the feasibility of using curcuminoids as protease inhibitors.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34865272</pmid><doi>10.1111/eos.12837</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1762-830X</orcidid><orcidid>https://orcid.org/0000-0003-0932-8531</orcidid><orcidid>https://orcid.org/0000-0002-1484-6774</orcidid><orcidid>https://orcid.org/0000-0003-4131-1959</orcidid></addata></record> |
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| ispartof | European journal of oral sciences, 2022-02, Vol.130 (1), p.e12837-n/a |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Bonding agents Bonding strength Collagen collagen matrix metalloproteinases Composite Resins - chemistry Curcumin cysteine cathepsins degradation Dental Bonding Dental materials Dental restorative materials Dentin Dentin - chemistry Dentin-Bonding Agents - chemistry Diarylheptanoids Dimethyl sulfoxide Etching Failure analysis Feasibility studies Fibrils Humans Materials Testing Microscopy, Electron, Scanning Molars Phosphoric acid Protease inhibitors Proteinase inhibitors Regression analysis Resin Cements - chemistry Saliva Scanning electron microscopy Teeth Tensile Strength |
| title | Long‐term effect of curcuminoid treatment on resin‐to‐dentin bond strength |
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