A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women
Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by comparing it to the reference method of fractional ir...
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| Veröffentlicht in: | Clinical nutrition ESPEN 2021-12, Vol.46, p.325-329 |
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| creator | El-Helou, Nehmat El-Mallah, Carla Wehbe, Nour Bissani, Nour Stoffel, Nicole Herter-Aeberli, Isabelle Zimmermann, Michael Obeid, Omar |
| description | Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by comparing it to the reference method of fractional iron absorption (FIA) using red blood cell incorporation of stable iron isotopes from a labeled iron dose. A second objective was to assess whether the OIAT could be done simultaneously with an oral glucose tolerance test (OGTT), since iron deficiency and glucose intolerance may coexist, especially among overweight individuals with low-grade inflammation.
In this prospective experimental study, 116 women were enrolled and IA was measured using two different approaches 1) FIA from a labeled test meal containing 6 mg of 57Fe and 2) the OIAT assessing ΔSeFe at 2 h after the intake of 100 mg oral iron, done simultaneously with an OGTT. Markers of iron status, glycaemia and inflammation, and serum hepcidin, were measured.
Prevalence of anemia and iron deficiency (defined as low serum ferritin) were 21% and 14%, respectively. ΔSeFe during the OIAT-OGTT was positively associated with FIA (r = 0.578, p |
| doi_str_mv | 10.1016/j.clnesp.2021.09.737 |
| format | Article |
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In this prospective experimental study, 116 women were enrolled and IA was measured using two different approaches 1) FIA from a labeled test meal containing 6 mg of 57Fe and 2) the OIAT assessing ΔSeFe at 2 h after the intake of 100 mg oral iron, done simultaneously with an OGTT. Markers of iron status, glycaemia and inflammation, and serum hepcidin, were measured.
Prevalence of anemia and iron deficiency (defined as low serum ferritin) were 21% and 14%, respectively. ΔSeFe during the OIAT-OGTT was positively associated with FIA (r = 0.578, p < 0.001). ΔSeFe was not significantly correlated with markers of glucose and insulin metabolism during the OIAT-OGTT.
The combined OIAT and OGTT method described here correlates well with FIA measured by stable iron isotopes, and could provide information on both IA and glucose tolerance in a single 2-h test, decreasing the burden on patients.
clinicaltrials.gov (NCT 03642223).</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2021.09.737</identifier><identifier>PMID: 34857214</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Anemia, Iron-Deficiency - diagnosis ; Female ; Glucose ; Humans ; Inflammation ; Iron ; Iron absorption ; Iron Isotopes ; Middle Aged ; Obesity ; OGTT ; OIAT ; Prospective Studies ; Serum iron ; Young Adult</subject><ispartof>Clinical nutrition ESPEN, 2021-12, Vol.46, p.325-329</ispartof><rights>2021 European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-f5e2a75d8e359bf4f4eea24505d8a1756420c586edf86e96b9114fcae504f0e73</cites><orcidid>0000-0003-4807-452X ; 0000-0003-0134-6217 ; 0000-0002-2693-6603 ; 0000-0002-7554-1296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34857214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Helou, Nehmat</creatorcontrib><creatorcontrib>El-Mallah, Carla</creatorcontrib><creatorcontrib>Wehbe, Nour</creatorcontrib><creatorcontrib>Bissani, Nour</creatorcontrib><creatorcontrib>Stoffel, Nicole</creatorcontrib><creatorcontrib>Herter-Aeberli, Isabelle</creatorcontrib><creatorcontrib>Zimmermann, Michael</creatorcontrib><creatorcontrib>Obeid, Omar</creatorcontrib><title>A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women</title><title>Clinical nutrition ESPEN</title><addtitle>Clin Nutr ESPEN</addtitle><description>Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by comparing it to the reference method of fractional iron absorption (FIA) using red blood cell incorporation of stable iron isotopes from a labeled iron dose. A second objective was to assess whether the OIAT could be done simultaneously with an oral glucose tolerance test (OGTT), since iron deficiency and glucose intolerance may coexist, especially among overweight individuals with low-grade inflammation.
In this prospective experimental study, 116 women were enrolled and IA was measured using two different approaches 1) FIA from a labeled test meal containing 6 mg of 57Fe and 2) the OIAT assessing ΔSeFe at 2 h after the intake of 100 mg oral iron, done simultaneously with an OGTT. Markers of iron status, glycaemia and inflammation, and serum hepcidin, were measured.
Prevalence of anemia and iron deficiency (defined as low serum ferritin) were 21% and 14%, respectively. ΔSeFe during the OIAT-OGTT was positively associated with FIA (r = 0.578, p < 0.001). ΔSeFe was not significantly correlated with markers of glucose and insulin metabolism during the OIAT-OGTT.
The combined OIAT and OGTT method described here correlates well with FIA measured by stable iron isotopes, and could provide information on both IA and glucose tolerance in a single 2-h test, decreasing the burden on patients.
clinicaltrials.gov (NCT 03642223).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia, Iron-Deficiency - diagnosis</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Iron</subject><subject>Iron absorption</subject><subject>Iron Isotopes</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>OGTT</subject><subject>OIAT</subject><subject>Prospective Studies</subject><subject>Serum iron</subject><subject>Young Adult</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PxCAQxYnRuGbdb2AMRy9bgUJbLiabjf-STbzombB0atjQUqHV7LeXTVfjyQvMkPfeMD-ErijJKKHF7S4zroPYZ4wwmhGZlXl5gi4YJ2LJRVme_qlnaBHjjpDkk5JTco5mOa9EySi_QMMKDxAHPHjcgo5jAOyDdtgG32G9jT70gz2UXY3f3Wh8hKR1EHRnAEfbjm7QHfgxuj22HabVIUoIvAcdsHc17gO00PlejzHlfvnUXKKzRrsIi-M9R28P96_rp-Xm5fF5vdosTU7psGwEMF2KuoJcyG3DGw6gGRckPWlaioIzYkRVQN2kQxZbSSlvjAZBeEOgzOfoZsrtg_8Y05qqtdGAc9OPFStIIVnFpExSPklN8DEGaFQfbKvDXlGiDsjVTk3I1QG5IlIl5Ml2fZwwbluof00_gJPgbhJA2vPTQlDRWEjsahvADKr29v8J31bilUk</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>El-Helou, Nehmat</creator><creator>El-Mallah, Carla</creator><creator>Wehbe, Nour</creator><creator>Bissani, Nour</creator><creator>Stoffel, Nicole</creator><creator>Herter-Aeberli, Isabelle</creator><creator>Zimmermann, Michael</creator><creator>Obeid, Omar</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4807-452X</orcidid><orcidid>https://orcid.org/0000-0003-0134-6217</orcidid><orcidid>https://orcid.org/0000-0002-2693-6603</orcidid><orcidid>https://orcid.org/0000-0002-7554-1296</orcidid></search><sort><creationdate>202112</creationdate><title>A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women</title><author>El-Helou, Nehmat ; El-Mallah, Carla ; Wehbe, Nour ; Bissani, Nour ; Stoffel, Nicole ; Herter-Aeberli, Isabelle ; Zimmermann, Michael ; Obeid, Omar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-f5e2a75d8e359bf4f4eea24505d8a1756420c586edf86e96b9114fcae504f0e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia, Iron-Deficiency - diagnosis</topic><topic>Female</topic><topic>Glucose</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Iron</topic><topic>Iron absorption</topic><topic>Iron Isotopes</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>OGTT</topic><topic>OIAT</topic><topic>Prospective Studies</topic><topic>Serum iron</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Helou, Nehmat</creatorcontrib><creatorcontrib>El-Mallah, Carla</creatorcontrib><creatorcontrib>Wehbe, Nour</creatorcontrib><creatorcontrib>Bissani, Nour</creatorcontrib><creatorcontrib>Stoffel, Nicole</creatorcontrib><creatorcontrib>Herter-Aeberli, Isabelle</creatorcontrib><creatorcontrib>Zimmermann, Michael</creatorcontrib><creatorcontrib>Obeid, Omar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Helou, Nehmat</au><au>El-Mallah, Carla</au><au>Wehbe, Nour</au><au>Bissani, Nour</au><au>Stoffel, Nicole</au><au>Herter-Aeberli, Isabelle</au><au>Zimmermann, Michael</au><au>Obeid, Omar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women</atitle><jtitle>Clinical nutrition ESPEN</jtitle><addtitle>Clin Nutr ESPEN</addtitle><date>2021-12</date><risdate>2021</risdate><volume>46</volume><spage>325</spage><epage>329</epage><pages>325-329</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by comparing it to the reference method of fractional iron absorption (FIA) using red blood cell incorporation of stable iron isotopes from a labeled iron dose. A second objective was to assess whether the OIAT could be done simultaneously with an oral glucose tolerance test (OGTT), since iron deficiency and glucose intolerance may coexist, especially among overweight individuals with low-grade inflammation.
In this prospective experimental study, 116 women were enrolled and IA was measured using two different approaches 1) FIA from a labeled test meal containing 6 mg of 57Fe and 2) the OIAT assessing ΔSeFe at 2 h after the intake of 100 mg oral iron, done simultaneously with an OGTT. Markers of iron status, glycaemia and inflammation, and serum hepcidin, were measured.
Prevalence of anemia and iron deficiency (defined as low serum ferritin) were 21% and 14%, respectively. ΔSeFe during the OIAT-OGTT was positively associated with FIA (r = 0.578, p < 0.001). ΔSeFe was not significantly correlated with markers of glucose and insulin metabolism during the OIAT-OGTT.
The combined OIAT and OGTT method described here correlates well with FIA measured by stable iron isotopes, and could provide information on both IA and glucose tolerance in a single 2-h test, decreasing the burden on patients.
clinicaltrials.gov (NCT 03642223).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34857214</pmid><doi>10.1016/j.clnesp.2021.09.737</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4807-452X</orcidid><orcidid>https://orcid.org/0000-0003-0134-6217</orcidid><orcidid>https://orcid.org/0000-0002-2693-6603</orcidid><orcidid>https://orcid.org/0000-0002-7554-1296</orcidid></addata></record> |
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| subjects | Adolescent Adult Anemia, Iron-Deficiency - diagnosis Female Glucose Humans Inflammation Iron Iron absorption Iron Isotopes Middle Aged Obesity OGTT OIAT Prospective Studies Serum iron Young Adult |
| title | A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women |
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