25-hydroxycholesterol–induced cell death via activation of ROCK/LIMK/cofilin axis in colorectal cancer cell spheroids

•25OHC induces cofilin phosphorylation in colorectal cancer spheroids.•Cytochalasin D and a LIMK inhibitor inhibit 25OHC-induced cell death in spheroids.•25OHC activates the ROCK pathway and actin rearrangement via caspase-3 activation.•DLD1 and HT29/WiDr cells differ in drug responsiveness and sphe...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2022-02, Vol.216, p.106037-106037, Article 106037
Hauptverfasser:	Hitsuda, Ayaho, Dan, Reona, Urakawa, Ayaka, Hiraoka, Yasuna, Murakami, Chiho, Yamamoto, Hideya, Tanaka, Arowu R.
Format:	Artikel
Sprache:	eng
Schlagworte:	25-hydroxycholesterol Actin Actin Depolymerizing Factors - metabolism Actin-depolymerizing protein Anoikis Antineoplastic Agents - pharmacology Apoptosis Cancer Caspase-3 Cell activation Cell death Cell Death - drug effects Cell Death - genetics Cofilin Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytochalasin D Cytoskeleton HT29 Cells Humans Hydroxycholesterols - pharmacology Kinases Lim Kinases - metabolism LIMK Phosphorylation Protein Kinase Inhibitors - pharmacology Rho rho-Associated Kinases - metabolism Signal Transduction - drug effects Signal Transduction - genetics Spheroid Spheroids Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Tumor cell lines Tumor Cells, Cultured
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