Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy

Adoptive cancer immunotherapy can induce objective clinical efficacy in patients with advanced cancer; however, a sustained response is achieved in a minority of cases. The persistence of infused T cells is an essential determinant of a durable therapeutic response. Antitumor T cells undergo a genom...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood 2022-04, Vol.139 (14), p.2156-2172
Hauptverfasser:	Yoshikawa, Toshiaki, Wu, Zhiwen, Inoue, Satoshi, Kasuya, Hitomi, Matsushita, Hirokazu, Takahashi, Yusuke, Kuroda, Hiroaki, Hosoda, Waki, Suzuki, Shiro, Kagoya, Yuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines Gene Knockout Techniques Humans Immunotherapy, Adoptive Lymphocyte Activation Neoplasms Positive Regulatory Domain I-Binding Factor 1 - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!