Involvement of Gap Junctions in Acetylcholine-Induced Endothelium-Derived Hyperpolarization-Type Dilation of Retinal Arterioles in Rats

An electrical communication between the endothelial and smooth muscle cells via gap junctions, which provides the signaling pathway known as endothelium-dependent hyperpolarization (EDH), plays a crucial role in controlling the vascular tone. In this study, we investigated the role of gap junctions...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/12/01, Vol.44(12), pp.1860-1865
Hauptverfasser:	Mori, Asami, Namekawa, Ryo, Sakamoto, Kenji, Ishii, Kunio, Nakahara, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - pharmacology Acids Animals Arginine Arterioles Arterioles - drug effects Calcium channels Calcium conductance Cell interactions Dilatation Endothelium Endothelium, Vascular - drug effects endothelium-dependent hyperpolarization Endothelium-Dependent Relaxing Factors gap junction Gap Junctions Hyperpolarization Indomethacin Injection Male Muscle, Smooth, Vascular NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide - metabolism Potassium channels (calcium-gated) Potassium conductance prostaglandin Prostaglandin endoperoxide synthase Rats Rats, Wistar Retina Retina - drug effects Retinal Vessels - drug effects Signal Transduction Smooth muscle Vasodilation Vasodilator Agents - pharmacology
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