Enantioselective Construction of Chiral Bispiro[Oxindole-Pyrrolidine-Pyrazolone] Derivatives via Sequential and One-Pot Mannich/Hydroamination Reaction

The atom-economic method for the preparation of novel bispirocyclic compounds containing three fused heterocyclic scaffolds privileged in drug discovery was developed by using a chiral amine-squaramide Mannich reaction and Au­(I)-catalyzed hydroamination. The developed synthetic strategy performed e...

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Veröffentlicht in:	Journal of organic chemistry 2021-12, Vol.86 (24), p.18139-18155
Hauptverfasser:	Urban, Michal, Nigríni, Martin, Císařová, Ivana, Veselý, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Molecular Structure Oxindoles Pyrazolones Pyrrolidines Stereoisomerism
Online-Zugang:	Volltext
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