Increasing Drug Loading of Weakly Acidic Telmisartan in Amorphous Solid Dispersions through pH Modification during Hot-Melt Extrusion

Oral drug therapy requiring large quantities of active pharmaceutical ingredients (APIs) can cause a substantial pill burden, which can increase nonadherence and worsen healthcare outcomes. Maximizing the drug loading of APIs in oral dosage forms is essential to reduce pill burden. This can be chall...

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Veröffentlicht in:	Molecular pharmaceutics 2022-01, Vol.19 (1), p.318-331
Hauptverfasser:	Thompson, Stephen A, Davis, Daniel A, Moon, Chaeho, Williams, Robert O
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Compounding - methods Drug Liberation Hot Melt Extrusion Technology - methods Hydrogen-Ion Concentration Telmisartan - administration & dosage Telmisartan - chemistry
Online-Zugang:	Volltext
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