Cordycepin induces M1/M2 macrophage polarization to attenuate the liver and lung damage and immunodeficiency in immature mice with sepsis via NF-κB/p65 inhibition

Abstract Objectives To explore the impacts of cordycepin and underlying mechanism on the sepsis. Methods The sepsis mice model was built and treated with different concentrations of cordycepin. Then the liver and lung injury caused by cecal ligation and puncture (CLP) was assessed using H&E stai...

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Veröffentlicht in:Journal of pharmacy and pharmacology 2022-02, Vol.74 (2), p.227-235
Hauptverfasser: Zhang, Yudan, Cheng, Jing, Su, Yufei, Li, Mingyue, Wen, Jun, Li, Sixiu
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Sprache:eng
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