Association analysis of MALAT1 polymorphisms and risk of psoriasis among Iranian patients
MALAT1 is a long non‐coding transcript that affects immune reactions, thus being involved in the pathoaetiology of immune‐related conditions. We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 ha...
Gespeichert in:
| Veröffentlicht in: | International journal of immunogenetics 2022-04, Vol.49 (2), p.83-87 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 87 |
|---|---|
| container_issue | 2 |
| container_start_page | 83 |
| container_title | International journal of immunogenetics |
| container_volume | 49 |
| creator | Ghafouri‐Fard, Soudeh Gholipour, Mahdi Abak, Atefe Hussen, Bashdar Mahmud Kholghi Oskooei, Vahid Taheri, Mohammad Rakhshan, Azadeh |
| description | MALAT1 is a long non‐coding transcript that affects immune reactions, thus being involved in the pathoaetiology of immune‐related conditions. We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95% confidence intervals (CI)) = 0.57 (0.36–0.9)), adjusted p = .02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95% CI) = 0.56 (0.35–0.92), adjusted p = .04) as well as log‐additive model (OR (95% CI) = 0.59 (0.38–0.92), adjusted p = .04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population. |
| doi_str_mv | 10.1111/iji.12562 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2604831278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2637784058</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-c34cc83e8b3a26d139c5b2c0117bc82174348c40d77e624c06d39bc385d0d913</originalsourceid><addsrcrecordid>eNp10LtOwzAUBmALgSgUBl4ARWKBoa1vuY1RxaWoiKUDTJbjuOCSxMGnEcrb45DSAQkP9hk-_fL5EbogeEr8mZmNmRIaRvQAnZCY8wkj7OVwP1MyQqcAG4xZxDk-RiPGEx7hND1BrxmAVUZuja0DWcuyAwOBXQdP2TJbkaCxZVdZ17wbqMCDInAGPnrQgHVG9lpWtn4LFk7WRtZB47N0vYUzdLSWJejz3TtGq7vb1fxhsny-X8yz5USxkFF_c6USppOcSRoVhKUqzKnChMS5SqhfwX9WcVzEsY4oVzgqWJorloQFLlLCxuh6iG2c_Ww1bEVlQOmylLW2LQgaYZ74DuLE06s_dGNb53fuFYvjhOOwVzeDUs4COL0WjTOVdJ0gWPR1C1-3-Knb28tdYptXutjL3349mA3gy5S6-z9JLB4XQ-Q3I6GIFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2637784058</pqid></control><display><type>article</type><title>Association analysis of MALAT1 polymorphisms and risk of psoriasis among Iranian patients</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Ghafouri‐Fard, Soudeh ; Gholipour, Mahdi ; Abak, Atefe ; Hussen, Bashdar Mahmud ; Kholghi Oskooei, Vahid ; Taheri, Mohammad ; Rakhshan, Azadeh</creator><creatorcontrib>Ghafouri‐Fard, Soudeh ; Gholipour, Mahdi ; Abak, Atefe ; Hussen, Bashdar Mahmud ; Kholghi Oskooei, Vahid ; Taheri, Mohammad ; Rakhshan, Azadeh</creatorcontrib><description>MALAT1 is a long non‐coding transcript that affects immune reactions, thus being involved in the pathoaetiology of immune‐related conditions. We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95% confidence intervals (CI)) = 0.57 (0.36–0.9)), adjusted p = .02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95% CI) = 0.56 (0.35–0.92), adjusted p = .04) as well as log‐additive model (OR (95% CI) = 0.59 (0.38–0.92), adjusted p = .04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population.</description><identifier>ISSN: 1744-3121</identifier><identifier>EISSN: 1744-313X</identifier><identifier>DOI: 10.1111/iji.12562</identifier><identifier>PMID: 34846099</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Association analysis ; Case-Control Studies ; Genetic diversity ; Genetic Predisposition to Disease ; Heredity ; Humans ; Iran - epidemiology ; lncRNA ; MALAT1 ; Polymorphism, Single Nucleotide ; Population genetics ; Psoriasis ; Psoriasis - epidemiology ; Psoriasis - genetics ; RNA, Long Noncoding - genetics ; rs3200401 ; rs619586 ; Single-nucleotide polymorphism ; Transcription</subject><ispartof>International journal of immunogenetics, 2022-04, Vol.49 (2), p.83-87</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-c34cc83e8b3a26d139c5b2c0117bc82174348c40d77e624c06d39bc385d0d913</citedby><cites>FETCH-LOGICAL-c3532-c34cc83e8b3a26d139c5b2c0117bc82174348c40d77e624c06d39bc385d0d913</cites><orcidid>0000-0001-8381-0591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiji.12562$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiji.12562$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34846099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghafouri‐Fard, Soudeh</creatorcontrib><creatorcontrib>Gholipour, Mahdi</creatorcontrib><creatorcontrib>Abak, Atefe</creatorcontrib><creatorcontrib>Hussen, Bashdar Mahmud</creatorcontrib><creatorcontrib>Kholghi Oskooei, Vahid</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><creatorcontrib>Rakhshan, Azadeh</creatorcontrib><title>Association analysis of MALAT1 polymorphisms and risk of psoriasis among Iranian patients</title><title>International journal of immunogenetics</title><addtitle>Int J Immunogenet</addtitle><description>MALAT1 is a long non‐coding transcript that affects immune reactions, thus being involved in the pathoaetiology of immune‐related conditions. We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95% confidence intervals (CI)) = 0.57 (0.36–0.9)), adjusted p = .02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95% CI) = 0.56 (0.35–0.92), adjusted p = .04) as well as log‐additive model (OR (95% CI) = 0.59 (0.38–0.92), adjusted p = .04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population.</description><subject>Association analysis</subject><subject>Case-Control Studies</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Heredity</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>lncRNA</subject><subject>MALAT1</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><subject>Psoriasis</subject><subject>Psoriasis - epidemiology</subject><subject>Psoriasis - genetics</subject><subject>RNA, Long Noncoding - genetics</subject><subject>rs3200401</subject><subject>rs619586</subject><subject>Single-nucleotide polymorphism</subject><subject>Transcription</subject><issn>1744-3121</issn><issn>1744-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtOwzAUBmALgSgUBl4ARWKBoa1vuY1RxaWoiKUDTJbjuOCSxMGnEcrb45DSAQkP9hk-_fL5EbogeEr8mZmNmRIaRvQAnZCY8wkj7OVwP1MyQqcAG4xZxDk-RiPGEx7hND1BrxmAVUZuja0DWcuyAwOBXQdP2TJbkaCxZVdZ17wbqMCDInAGPnrQgHVG9lpWtn4LFk7WRtZB47N0vYUzdLSWJejz3TtGq7vb1fxhsny-X8yz5USxkFF_c6USppOcSRoVhKUqzKnChMS5SqhfwX9WcVzEsY4oVzgqWJorloQFLlLCxuh6iG2c_Ww1bEVlQOmylLW2LQgaYZ74DuLE06s_dGNb53fuFYvjhOOwVzeDUs4COL0WjTOVdJ0gWPR1C1-3-Knb28tdYptXutjL3349mA3gy5S6-z9JLB4XQ-Q3I6GIFA</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Ghafouri‐Fard, Soudeh</creator><creator>Gholipour, Mahdi</creator><creator>Abak, Atefe</creator><creator>Hussen, Bashdar Mahmud</creator><creator>Kholghi Oskooei, Vahid</creator><creator>Taheri, Mohammad</creator><creator>Rakhshan, Azadeh</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8381-0591</orcidid></search><sort><creationdate>202204</creationdate><title>Association analysis of MALAT1 polymorphisms and risk of psoriasis among Iranian patients</title><author>Ghafouri‐Fard, Soudeh ; Gholipour, Mahdi ; Abak, Atefe ; Hussen, Bashdar Mahmud ; Kholghi Oskooei, Vahid ; Taheri, Mohammad ; Rakhshan, Azadeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-c34cc83e8b3a26d139c5b2c0117bc82174348c40d77e624c06d39bc385d0d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Association analysis</topic><topic>Case-Control Studies</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Heredity</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>lncRNA</topic><topic>MALAT1</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population genetics</topic><topic>Psoriasis</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - genetics</topic><topic>RNA, Long Noncoding - genetics</topic><topic>rs3200401</topic><topic>rs619586</topic><topic>Single-nucleotide polymorphism</topic><topic>Transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghafouri‐Fard, Soudeh</creatorcontrib><creatorcontrib>Gholipour, Mahdi</creatorcontrib><creatorcontrib>Abak, Atefe</creatorcontrib><creatorcontrib>Hussen, Bashdar Mahmud</creatorcontrib><creatorcontrib>Kholghi Oskooei, Vahid</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><creatorcontrib>Rakhshan, Azadeh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghafouri‐Fard, Soudeh</au><au>Gholipour, Mahdi</au><au>Abak, Atefe</au><au>Hussen, Bashdar Mahmud</au><au>Kholghi Oskooei, Vahid</au><au>Taheri, Mohammad</au><au>Rakhshan, Azadeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association analysis of MALAT1 polymorphisms and risk of psoriasis among Iranian patients</atitle><jtitle>International journal of immunogenetics</jtitle><addtitle>Int J Immunogenet</addtitle><date>2022-04</date><risdate>2022</risdate><volume>49</volume><issue>2</issue><spage>83</spage><epage>87</epage><pages>83-87</pages><issn>1744-3121</issn><eissn>1744-313X</eissn><abstract>MALAT1 is a long non‐coding transcript that affects immune reactions, thus being involved in the pathoaetiology of immune‐related conditions. We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95% confidence intervals (CI)) = 0.57 (0.36–0.9)), adjusted p = .02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95% CI) = 0.56 (0.35–0.92), adjusted p = .04) as well as log‐additive model (OR (95% CI) = 0.59 (0.38–0.92), adjusted p = .04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34846099</pmid><doi>10.1111/iji.12562</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8381-0591</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1744-3121 |
| ispartof | International journal of immunogenetics, 2022-04, Vol.49 (2), p.83-87 |
| issn | 1744-3121 1744-313X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2604831278 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Association analysis Case-Control Studies Genetic diversity Genetic Predisposition to Disease Heredity Humans Iran - epidemiology lncRNA MALAT1 Polymorphism, Single Nucleotide Population genetics Psoriasis Psoriasis - epidemiology Psoriasis - genetics RNA, Long Noncoding - genetics rs3200401 rs619586 Single-nucleotide polymorphism Transcription |
| title | Association analysis of MALAT1 polymorphisms and risk of psoriasis among Iranian patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T00%3A02%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20analysis%20of%20MALAT1%20polymorphisms%20and%20risk%20of%20psoriasis%20among%20Iranian%20patients&rft.jtitle=International%20journal%20of%20immunogenetics&rft.au=Ghafouri%E2%80%90Fard,%20Soudeh&rft.date=2022-04&rft.volume=49&rft.issue=2&rft.spage=83&rft.epage=87&rft.pages=83-87&rft.issn=1744-3121&rft.eissn=1744-313X&rft_id=info:doi/10.1111/iji.12562&rft_dat=%3Cproquest_cross%3E2637784058%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2637784058&rft_id=info:pmid/34846099&rfr_iscdi=true |