The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid

Monocopper lytic polysaccharide monooxygenases (LPMOs) catalyse oxidative cleavage of glycosidic bonds in a reductant‐dependent reaction. Recent studies indicate that LPMOs, rather than being O2‐dependent monooxygenases, are H2O2‐dependent peroxygenases. Here, we describe SscLPMO10B, a novel LPMO fr...

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Veröffentlicht in:	FEBS letters 2022-01, Vol.596 (1), p.53-70
Hauptverfasser:	Stepnov, Anton A., Christensen, Idd A., Forsberg, Zarah, Aachmann, Finn L., Courtade, Gaston, Eijsink, Vincent G. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biocatalysis Catalysis Catalytic Domain Cellulose - metabolism Copper - chemistry Copper - metabolism Cysteine - metabolism dehydroascorbic acid Dehydroascorbic Acid - metabolism enzyme kinetics hydrogen peroxide Hydrogen Peroxide - metabolism Kinetics LPMO Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism NMR Oxidation-Reduction Polysaccharides - metabolism Reducing Agents - metabolism Streptomyces - enzymology
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