Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice

Decreased energy metabolism and mitochondrial biogenesis defects are implicated in the pathogenesis of Alzheimer's disease (AD). In present study, mitochondriomics analysis revealed significant effects of R13, a prodrug of 7,8-dihydroxyflavone, on mitochondrial protein expression profile, inclu...

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Veröffentlicht in:	Neuropharmacology 2022-02, Vol.204, p.108899-108899, Article 108899
Hauptverfasser:	Li, Ting, Li, Xiao, Huang, Xi, Yu, Hao, Li, Shupeng, Zhang, Zaijun, Xie, Yongmei, Song, Xiangrong, Liu, Jianjun, Yang, Xifei, Liu, Gongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - etiology Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Electron Transport Energy Metabolism - drug effects Fatty Acids - metabolism Flavanones - pharmacology Flavanones - therapeutic use Male Mice, Transgenic Mitochondria - genetics Mitochondria - metabolism Mitochondrial biogenesis Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular Targeted Therapy Organelle Biogenesis Oxidation-Reduction OXPHOS Phosphorylation - drug effects Prodrugs - pharmacology Prodrugs - therapeutic use Proteomics Receptor, trkB - agonists Receptor, trkB - metabolism tau Proteins - metabolism Transcriptome - genetics TrkB
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