Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks
Background and Objectives The use of inhaled nitric oxide (iNO) in +late preterm and term infants with pulmonary hypertension is Food and Drug Administration (FDA) approved and has improved outcomes and survival. iNO use is not FDA approved for preterm infants and previous studies show no mortality...
Gespeichert in:
| Veröffentlicht in: | Pediatric pulmonology 2022-02, Vol.57 (2), p.427-434 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 434 |
|---|---|
| container_issue | 2 |
| container_start_page | 427 |
| container_title | Pediatric pulmonology |
| container_volume | 57 |
| creator | Peluso, Allison M. Othman, Hasan F. Karnati, Sreenivas Sammour, Ibrahim Aly, Hany Z. |
| description | Background and Objectives
The use of inhaled nitric oxide (iNO) in +late preterm and term infants with pulmonary hypertension is Food and Drug Administration (FDA) approved and has improved outcomes and survival. iNO use is not FDA approved for preterm infants and previous studies show no mortality benefit. The objectives were 1) to determine the usage of iNO among preterm neonates |
| doi_str_mv | 10.1002/ppul.25775 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2604466495</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622139883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3575-72832b05afffdae93acc60e4f4ace93a28b65926b15590b5290985d3179635e73</originalsourceid><addsrcrecordid>eNp90TtPwzAQB3ALgWh5LHwAZIkFIaX4ETvxiBAvqRIdYI6c5NK6deIQJxS-PW4LDAxMlnU__3XnQ-iMkgklhF237WAnTCSJ2ENjSpSKSKzkPhqniRCRTCUfoSPvl4SEmqKHaMTjNGZcsDFa3bWmhNo46-amwPCu7aB74xrsKmyahbZQ4sb0XSi6j0Dx4AHr2jVz3IBrdA8er02_wHPw_faltljPAVvwHvcL3WAu8Bpg5U_QQaWth9Pv8xi93t-93D5G0-eHp9ubaVRwkYgoYSlnORG6qqpSg-K6KCSBuIp1sbmxNJdCMZlTIRTJBVNEpaLkNFGSC0j4Mbrc5badextCW1ltfAHW6tDx4DMmSRxLGSsR6MUfunRDF0bYKMYoV2nKg7raqaJz3ndQZW1nat19ZpRkmxVkmxVk2xUEfP4dOeQ1lL_0588DoDuwNhY-_4nKZrPX6S70C5fKkU8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622139883</pqid></control><display><type>article</type><title>Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Peluso, Allison M. ; Othman, Hasan F. ; Karnati, Sreenivas ; Sammour, Ibrahim ; Aly, Hany Z.</creator><creatorcontrib>Peluso, Allison M. ; Othman, Hasan F. ; Karnati, Sreenivas ; Sammour, Ibrahim ; Aly, Hany Z.</creatorcontrib><description>Background and Objectives
The use of inhaled nitric oxide (iNO) in +late preterm and term infants with pulmonary hypertension is Food and Drug Administration (FDA) approved and has improved outcomes and survival. iNO use is not FDA approved for preterm infants and previous studies show no mortality benefit. The objectives were 1) to determine the usage of iNO among preterm neonates <35 weeks before and after the 2010 National Institutes of Health consensus statement and 2) to evaluate characteristics and outcomes among preterm neonates who received iNO.
Methods
This is a population‐based cross‐sectional study. Billing and procedure codes were used to determine iNO usage. Data were queried from the National Inpatient Sample from 2004 to 2016. Neonates were included if gestational age was <35 weeks. The epochs were spilt into 2004–2010 (Epoch 1) and 2011–2016 (Epoch 2). Prevalence of iNO use, mortality, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage, length of stay, mechanical ventilation, and cost of hospitalization.
Results
There were 4865 preterm neonates <35 weeks who received iNO. There was a significant increase in iNO use during Epoch 2 (p < 0.001). There was significantly higher use in Epoch 2 among neonates small for gestational age (SGA) 2.3% versus 7.2%, congenital heart disease (CHD) 11.1% versus 18.6%, and BPD 35.2% versus 46.8%. Mortality was significantly lower in Epoch 2 19.8% versus 22.7%.
Conclusion
Usage of iNO was higher after the release of the consensus statement. The increased use of iNO among preterm neonates may be targeted at specific high‐risk populations such as SGA and CHD neonates. There was lower mortality in Epoch 2; however, the cost was doubled.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.25775</identifier><identifier>PMID: 34842352</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Administration, Inhalation ; Cross-Sectional Studies ; FDA approval ; Gestational Age ; health services ; Humans ; hypoxic respiratory failure ; Infant ; Infant, Newborn ; Infant, Premature ; Mortality ; Nitric oxide ; Nitric Oxide - therapeutic use ; prematurity ; pulmonary hypertension</subject><ispartof>Pediatric pulmonology, 2022-02, Vol.57 (2), p.427-434</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><rights>2022 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3575-72832b05afffdae93acc60e4f4ace93a28b65926b15590b5290985d3179635e73</citedby><cites>FETCH-LOGICAL-c3575-72832b05afffdae93acc60e4f4ace93a28b65926b15590b5290985d3179635e73</cites><orcidid>0000-0001-9825-0822 ; 0000-0001-7395-6394</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.25775$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.25775$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34842352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peluso, Allison M.</creatorcontrib><creatorcontrib>Othman, Hasan F.</creatorcontrib><creatorcontrib>Karnati, Sreenivas</creatorcontrib><creatorcontrib>Sammour, Ibrahim</creatorcontrib><creatorcontrib>Aly, Hany Z.</creatorcontrib><title>Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Background and Objectives
The use of inhaled nitric oxide (iNO) in +late preterm and term infants with pulmonary hypertension is Food and Drug Administration (FDA) approved and has improved outcomes and survival. iNO use is not FDA approved for preterm infants and previous studies show no mortality benefit. The objectives were 1) to determine the usage of iNO among preterm neonates <35 weeks before and after the 2010 National Institutes of Health consensus statement and 2) to evaluate characteristics and outcomes among preterm neonates who received iNO.
Methods
This is a population‐based cross‐sectional study. Billing and procedure codes were used to determine iNO usage. Data were queried from the National Inpatient Sample from 2004 to 2016. Neonates were included if gestational age was <35 weeks. The epochs were spilt into 2004–2010 (Epoch 1) and 2011–2016 (Epoch 2). Prevalence of iNO use, mortality, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage, length of stay, mechanical ventilation, and cost of hospitalization.
Results
There were 4865 preterm neonates <35 weeks who received iNO. There was a significant increase in iNO use during Epoch 2 (p < 0.001). There was significantly higher use in Epoch 2 among neonates small for gestational age (SGA) 2.3% versus 7.2%, congenital heart disease (CHD) 11.1% versus 18.6%, and BPD 35.2% versus 46.8%. Mortality was significantly lower in Epoch 2 19.8% versus 22.7%.
Conclusion
Usage of iNO was higher after the release of the consensus statement. The increased use of iNO among preterm neonates may be targeted at specific high‐risk populations such as SGA and CHD neonates. There was lower mortality in Epoch 2; however, the cost was doubled.</description><subject>Administration, Inhalation</subject><subject>Cross-Sectional Studies</subject><subject>FDA approval</subject><subject>Gestational Age</subject><subject>health services</subject><subject>Humans</subject><subject>hypoxic respiratory failure</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Mortality</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - therapeutic use</subject><subject>prematurity</subject><subject>pulmonary hypertension</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90TtPwzAQB3ALgWh5LHwAZIkFIaX4ETvxiBAvqRIdYI6c5NK6deIQJxS-PW4LDAxMlnU__3XnQ-iMkgklhF237WAnTCSJ2ENjSpSKSKzkPhqniRCRTCUfoSPvl4SEmqKHaMTjNGZcsDFa3bWmhNo46-amwPCu7aB74xrsKmyahbZQ4sb0XSi6j0Dx4AHr2jVz3IBrdA8er02_wHPw_faltljPAVvwHvcL3WAu8Bpg5U_QQaWth9Pv8xi93t-93D5G0-eHp9ubaVRwkYgoYSlnORG6qqpSg-K6KCSBuIp1sbmxNJdCMZlTIRTJBVNEpaLkNFGSC0j4Mbrc5badextCW1ltfAHW6tDx4DMmSRxLGSsR6MUfunRDF0bYKMYoV2nKg7raqaJz3ndQZW1nat19ZpRkmxVkmxVk2xUEfP4dOeQ1lL_0588DoDuwNhY-_4nKZrPX6S70C5fKkU8</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Peluso, Allison M.</creator><creator>Othman, Hasan F.</creator><creator>Karnati, Sreenivas</creator><creator>Sammour, Ibrahim</creator><creator>Aly, Hany Z.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9825-0822</orcidid><orcidid>https://orcid.org/0000-0001-7395-6394</orcidid></search><sort><creationdate>202202</creationdate><title>Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks</title><author>Peluso, Allison M. ; Othman, Hasan F. ; Karnati, Sreenivas ; Sammour, Ibrahim ; Aly, Hany Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3575-72832b05afffdae93acc60e4f4ace93a28b65926b15590b5290985d3179635e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Administration, Inhalation</topic><topic>Cross-Sectional Studies</topic><topic>FDA approval</topic><topic>Gestational Age</topic><topic>health services</topic><topic>Humans</topic><topic>hypoxic respiratory failure</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Mortality</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - therapeutic use</topic><topic>prematurity</topic><topic>pulmonary hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peluso, Allison M.</creatorcontrib><creatorcontrib>Othman, Hasan F.</creatorcontrib><creatorcontrib>Karnati, Sreenivas</creatorcontrib><creatorcontrib>Sammour, Ibrahim</creatorcontrib><creatorcontrib>Aly, Hany Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peluso, Allison M.</au><au>Othman, Hasan F.</au><au>Karnati, Sreenivas</au><au>Sammour, Ibrahim</au><au>Aly, Hany Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2022-02</date><risdate>2022</risdate><volume>57</volume><issue>2</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Background and Objectives
The use of inhaled nitric oxide (iNO) in +late preterm and term infants with pulmonary hypertension is Food and Drug Administration (FDA) approved and has improved outcomes and survival. iNO use is not FDA approved for preterm infants and previous studies show no mortality benefit. The objectives were 1) to determine the usage of iNO among preterm neonates <35 weeks before and after the 2010 National Institutes of Health consensus statement and 2) to evaluate characteristics and outcomes among preterm neonates who received iNO.
Methods
This is a population‐based cross‐sectional study. Billing and procedure codes were used to determine iNO usage. Data were queried from the National Inpatient Sample from 2004 to 2016. Neonates were included if gestational age was <35 weeks. The epochs were spilt into 2004–2010 (Epoch 1) and 2011–2016 (Epoch 2). Prevalence of iNO use, mortality, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage, length of stay, mechanical ventilation, and cost of hospitalization.
Results
There were 4865 preterm neonates <35 weeks who received iNO. There was a significant increase in iNO use during Epoch 2 (p < 0.001). There was significantly higher use in Epoch 2 among neonates small for gestational age (SGA) 2.3% versus 7.2%, congenital heart disease (CHD) 11.1% versus 18.6%, and BPD 35.2% versus 46.8%. Mortality was significantly lower in Epoch 2 19.8% versus 22.7%.
Conclusion
Usage of iNO was higher after the release of the consensus statement. The increased use of iNO among preterm neonates may be targeted at specific high‐risk populations such as SGA and CHD neonates. There was lower mortality in Epoch 2; however, the cost was doubled.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34842352</pmid><doi>10.1002/ppul.25775</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9825-0822</orcidid><orcidid>https://orcid.org/0000-0001-7395-6394</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-6863 |
| ispartof | Pediatric pulmonology, 2022-02, Vol.57 (2), p.427-434 |
| issn | 8755-6863 1099-0496 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2604466495 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Administration, Inhalation Cross-Sectional Studies FDA approval Gestational Age health services Humans hypoxic respiratory failure Infant Infant, Newborn Infant, Premature Mortality Nitric oxide Nitric Oxide - therapeutic use prematurity pulmonary hypertension |
| title | Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T05%3A34%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiologic%20evaluation%20of%20inhaled%20nitric%20oxide%20use%20among%20neonates%20with%20gestational%20age%20less%20than%2035%20weeks&rft.jtitle=Pediatric%20pulmonology&rft.au=Peluso,%20Allison%20M.&rft.date=2022-02&rft.volume=57&rft.issue=2&rft.spage=427&rft.epage=434&rft.pages=427-434&rft.issn=8755-6863&rft.eissn=1099-0496&rft_id=info:doi/10.1002/ppul.25775&rft_dat=%3Cproquest_cross%3E2622139883%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2622139883&rft_id=info:pmid/34842352&rfr_iscdi=true |